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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Beta-3 adrenergic receptor
Species	Canis lupus familiaris (Dog)
Gene	ADRB3
Synonym	Beta-3 adrenoceptor Beta-3 adrenoreceptor
Disease	N/A for non-human GPCRs
Length	405
Amino acid sequence	MAPWPHGNGSVASWPAAPTPTPDAANTSGLPGAPWAVALAGALLALEVLATVGGNLLVIVAIARTPRLQTMTNVFVTSLATADLVVGLLVVPPGATLALTGRWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRRARAAVVLVWVVSAAVSFAPIMSKWWRVGADAEAQRCHSNPHCCAFASNIPYALLSSSVSFYLPLLVMLFVYARVFLVATRQLRLLRRELGRFPPAESPPAASRSRSPGPARRCASPAAVPSDRLRPARLLPLREHRALRTLGLIVGTFTLCWLPFFVANVMRALGGPSLVPSPALLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCRREEHRAAASPPGDPSAAPAALTSPAESSRCQALDGASWGIS
UniProt	O02662
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4400
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL470292
Molecular formula	C25H28N2O4
IUPAC name	4-[4-[2-[[(2R)-2-hydroxy-2-pyridin-3-ylethyl]amino]ethyl]phenyl]-2-propan-2-yloxybenzoic acid
Molecular weight	420.509
Hydrogen bond acceptor	6
Hydrogen bond donor	3
XlogP	1.2
Synonyms	(R)-4''-(2-(2-hydroxy-2-(pyridin-3-yl)ethylamino)ethyl)-3-isopropoxybiphenyl-4-carboxylic acid BDBM50243064 4-(2-{[(2R)-2-Hydroxy-2-(3-pyridinyl)ethyl]amino}ethyl)-3-isopropoxy-4-biphenylcarboxylic acid
Inchi Key	YNNCJPLSEBDJPD-QHCPKHFHSA-N
Inchi ID	InChI=1S/C25H28N2O4/c1-17(2)31-24-14-20(9-10-22(24)25(29)30)19-7-5-18(6-8-19)11-13-27-16-23(28)21-4-3-12-26-15-21/h3-10,12,14-15,17,23,27-28H,11,13,16H2,1-2H3,(H,29,30)/t23-/m0/s1
PubChem CID	24895783
ChEMBL	CHEMBL470292
IUPHAR	N/A
BindingDB	50243064
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	10.0 nM	PMID19366244	BindingDB,ChEMBL
EC50	11.0 nM	PMID18553954	BindingDB,ChEMBL
Intrinsic activity	0.87 -	PMID18553954	ChEMBL

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