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GLASS

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GPCR

Name	5-hydroxytryptamine receptor 1D
Species	Homo sapiens (Human)
Gene	HTR1D
Synonym	Serotonin 1D alpha receptor serotonin receptor 1D HTRL Htr1db 5-HT-1D 5-HT-1D-alpha 5-HT1D 5-HT1D receptor 5-HT1Dalpha 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled Gpcr14 HT1DA [ Show all ]
Disease	Acute migraine Epilepsy Migraine headaches Mood disorder Migraine Major depressive disorder Severe mood disorders [ Show all ]
Length	377
Amino acid sequence	MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS
UniProt	P28221
Protein Data Bank	N/A
GPCR-HGmod model	P28221
3D structure model	This predicted structure model is from GPCR-EXP P28221.
BioLiP	N/A
Therapeutic Target Database	T11072
ChEMBL	CHEMBL1983
IUPHAR	3
DrugBank	BE0000659

Ligand

Name	chlorpromazine
Molecular formula	C17H19ClN2S
IUPAC name	3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine
Molecular weight	318.863
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	5.2
Synonyms	Norcozine (Salt/Mix) KBio3_002792 CCG-40059 NSC756689 KUC112482N Chlorderazin Plegomasine Chlorpromazine (USP/INN) Promactil 2-chloro-10-[3-(dimethylamino)propyl]- Clorpromazina QTL1_000021 3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-1-propanamine Largactil (TN) D00270 SKF 2601A 4560 Rp hydrochloride LS-105361 DTXSID0022808 Spectrum4_000283 AB00051943_18 NCGC00015273-01 FT-0653683 Thorazine hydrochloride Ampliactil NCGC00015273-09 HMS3430C19 UNII-U42B7VYA4P BC 135 NCGC00015273-17 KBio1_000624 [3-(2-chloro-10H-phenothiazin-10-yl)propyl]dimethylamine hydrochloride BPBio1_001181 BSPBio_002011 NSC 167745 KBioSS_000622 Phenactyl Chloropromazine Prestwick0_000064 10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl-, radical ion(1+) Chlorpromazine [USAN:INN:BAN] Propaphen 2-Chloropromazine cMAP_000017 Sanopron 3-(2-chlorophenothiazin-10-yl)-N,N-dimethyl-propan-1-amine Largactilothiazine DB00477 SPBio_001111 MCULE-5976054678 Epitope ID:136898 SR-01000000012-5 AKOS001490972 NCGC00015273-04 Hibernal (Salt/Mix) Torazina AN-41563 NCGC00015273-12 I14-6226 WLN: T C666 BN ISJ B3N1&1 EG Bio1_000457 NCGC00024409-05 KBio2_003190 [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine( Chlorpromazine) KBio2_007448 CAS-50-53-3 NSC167745 KS-5101 Chlor-PZ Phenothiazine, 2-chloro-10-(3-(dimethylamino)propyl)- (chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine Chlorpromazin Prestwick3_000064 2-Chloro-10-(3-(dimethylamino)propyl)phenothiazine Chlorpromazinum Psychozine 2601-A L000182 Cromedazine SCHEMBL8321 4560 R.P Lopac-C-8138 DSSTox_GSID_22808 Spectrum2_001156 AB00051943-16 MolPort-001-727-953 Fenaktyl Thorazine Aminazin NCGC00015273-07 HMS2089C12 Tranzine (Salt/Mix) BAS 00010434 NCGC00015273-15 JHICC02042 ZPEIMTDSQAKGNT-UHFFFAOYSA-N Biomol-NT_000020 NCGC00024409-08 BRD-K89997465-001-05-3 Novo-Chlorpromazine KBioGR_000806 CCRIS 3711 Oprea1_110255 Chloro-3 (dimethylamino-3 propyl)-10 phenothiazine Plegomazin 10-(3-Dimethylaminopropyl)-2-chlorophenothiazine Chlorpromazine cation radical Promapar 2-Chloro-10-[3-(dimethylamino)propyl]phenothiazine Clorpromazina [INN-Spanish] R1242 3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-1-propanamine # Largactil Liquid D01ZII SKF-2601 50-53-3 M-1209 EINECS 200-045-8 Spectrum5_000717 AB0015094 NCGC00015273-02 GG 407 Thorazine Spansule Amplicitil NCGC00015273-10 HMS501P06 Unitensen BCP03610 NCGC00015273-19 KBio2_000622 [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine(clorpromazine) C06906 NSC-167745 KBioSS_002314 CHEMBL71 Phenathyl Chlorpromados Prestwick1_000064 1N,1N-dimethyl-3-(2-chloro-10H-10-phenothiazinyl)-1-propanamine Chlorpromazine [USP:INN:BAN] Propaphenin 2-Cloro-10 (3-dimetilaminopropil)fenotiazina Contomin SBI-0050237.P004 3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine Largactyl DivK1c_000624 SPBio_002168 AB00051943 Megaphen Esmind SR-01000000012-6 ALBB-022464 NCGC00015273-05 HL 5746 Tox21_110120 API0001970 NCGC00015273-13 IDI1_000624 Z80 Bio1_000946 NCGC00024409-06 KBio2_004880 KBio3_001231 CAS-69-09-0 NSC17479 KSC-315-032- Chlordelazine Phenothiazine, 2-chloro-10-[3-(dimethylamino)propyl]- (chlorpromazine)[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine Proma 2-Chloro-10-(3-dimethylaminopropyl)phenothiazine Chlorpromazinum [INN-Latin] QSPL 401 2601A Largactil CTK1C5154 SKF 2601-A 4560 R.P. Lopac0_000249 DSSTox_RID_76736 Spectrum3_000346 AB00051943_17 N-(3-Dimethylaminopropyl)-3-chlorophenothiazine Fraction AB Thorazine (TN) Aminazine NCGC00015273-08 HMS2091E06 U42B7VYA4P BBL028251 NCGC00015273-16 KB-232587 [3-(2-chloro-10H-phenothiazin-10-yl)propyl]dimethylamine BPBio1_000273 NINDS_000624 BSPBio_000247 Novomazina KBioGR_002312 CHEBI:3647 Pharmakon1600-01500184 Chloro-3 (dimethylamino-3 propyl)-10 phenothiazine [French] Prazilpromactil 10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl- Chlorpromazine Tannate Promazil 2-chloro-N,N-dimethyl-10H-Phenothiazine-10-propanamine Clorpromazina [Italian] RP-4560 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine Largactil Oral Drops SMR001453710 M176 Elmarin Spectrum_000142 AC1L1EBT NCGC00015273-03 GTPL83 Thorazine Suppositories Amplictil NCGC00015273-11 HSDB 3033 Wintermin BDBM50001888 NCGC00024409-04 KBio2_002312 [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine (chlor-promazine) KBio2_005758 C17H19ClN2S NSC-756689 KS-00002WW5 Chlor-Promanyl Phenothiazine hydrochloride Chlorpromanyl (discontinued) Prestwick2_000064 2-chloro-10-(3-(dimethylamino)propyl)-phenothiazine Chlorpromazine;[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine Prozil 2-Cloro-10 (3-dimetilaminopropil)fenotiazina [Italian] CPZ SC-50091 34468-21-8 Lomazine (Salt/Mix) DSSTox_CID_2808 SPECTRUM1500184 AB00051943-15 MLS003166901 Fenactil STK182870 Aminasine NCGC00015273-06 HMS1920M03 Tox21_110120_1 AX8120990 NCGC00015273-14 J10069 ZINC44027 Bio1_001435 NCGC00024409-07 [ Show all ]
Inchi Key	ZPEIMTDSQAKGNT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3
PubChem CID	2726
ChEMBL	CHEMBL71
IUPHAR	83
BindingDB	50001888
DrugBank	DB00477
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	452.0 nM	http://pdsp.med.unc.edu/pdsp.php	PDSP

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