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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	P2Y purinoceptor 4
Species	Homo sapiens (Human)
Gene	P2RY4
Synonym	UNR pyrimidinoceptor pyrimidinergic receptor P2Y P2Y4R P2Y4 receptor P2Y4 P2Y purinoceptor 4 P2Y ATP receptor 4 P2P NRU uridine nucleotide receptor [ Show all ]
Disease	N/A
Length	365
Amino acid sequence	MASTESSLLRSLGLSPGPGSSEVELDCWFDEDFKFILLPVSYAVVFVLGLGLNAPTLWLFIFRLRPWDATATYMFHLALSDTLYVLSLPTLIYYYAAHNHWPFGTEICKFVRFLFYWNLYCSVLFLTCISVHRYLGICHPLRALRWGRPRLAGLLCLAVWLVVAGCLVPNLFFVTTSNKGTTVLCHDTTRPEEFDHYVHFSSAVMGLLFGVPCLVTLVCYGLMARRLYQPLPGSAQSSSRLRSLRTIAVVLTVFAVCFVPFHITRTIYYLARLLEADCRVLNIVNVVYKVTRPLASANSCLDPVLYLLTGDKYRRQLRQLCGGGKPQPRTAASSLALVSLPEDSSCRWAATPQDSSCSTPRADRL
UniProt	P51582
Protein Data Bank	N/A
GPCR-HGmod model	P51582
3D structure model	This predicted structure model is from GPCR-EXP P51582.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2123
IUPHAR	325
DrugBank	N/A

Ligand

Name	CHEMBL469243
Molecular formula	C18H29N4O10P
IUPAC name	(2S,3S,4R,5R)-N-[4-(diethoxyphosphorylmethylamino)-4-oxobutyl]-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolane-2-carboxamide
Molecular weight	492.422
Hydrogen bond acceptor	10
Hydrogen bond donor	5
XlogP	-2.6
Synonyms	SCHEMBL13210980 4-[(2S,3R,4S,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofurane-2-carboxamido]butylamidomethylphosphonic acid diethyl ester BDBM50262311
Inchi Key	ZSWHPAZLBPPJLA-QSJFSLAZSA-N
Inchi ID	InChI=1S/C18H29N4O10P/c1-3-30-33(29,31-4-2)10-20-11(23)6-5-8-19-16(27)15-13(25)14(26)17(32-15)22-9-7-12(24)21-18(22)28/h7,9,13-15,17,25-26H,3-6,8,10H2,1-2H3,(H,19,27)(H,20,23)(H,21,24,28)/t13-,14+,15-,17+/m0/s1
PubChem CID	24949083
ChEMBL	CHEMBL469243
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	21.0 %	PMID18630897	ChEMBL

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