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GPCR

NameC-X-C chemokine receptor type 2
SpeciesHomo sapiens (Human)
GeneCXCR2
Synonymchemokine (C-X-C motif) receptor 2
KC receptor
CD128
IL8RB
IL-8R2
[ Show all ]
DiseaseCystic fibrosis; Chronic obstructive pulmonary disease
Asthma
Cancer
Ischemia-reperfusion injury; Lung transplantation; Graft rejection in heart transplantation
Fungal infections
[ Show all ]
Length360
Amino acid sequenceMEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
UniProtP25025
Protein Data BankN/A
GPCR-HGmod modelP25025
3D structure modelThis predicted structure model is from GPCR-EXP P25025.
BioLiPN/A
Therapeutic Target DatabaseT56923
ChEMBLCHEMBL2434
IUPHAR69
DrugBankN/A

Ligand

NameCHEMBL3342292
Molecular formulaC19H14FN3O3S
IUPAC nameN-(4-fluorophenyl)-6-[(4-nitrophenyl)methylsulfanyl]pyridine-3-carboxamide
Molecular weight383.397
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP4.0
SynonymsBDBM150850
BDBM50028387
US8981106, 39
Inchi KeyARSWLECEUGEWQH-UHFFFAOYSA-N
Inchi IDInChI=1S/C19H14FN3O3S/c20-15-4-6-16(7-5-15)22-19(24)14-3-10-18(21-11-14)27-12-13-1-8-17(9-2-13)23(25)26/h1-11H,12H2,(H,22,24)
PubChem CID46897632
ChEMBLCHEMBL3342292
IUPHARN/A
BindingDB50028387, 150850
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50<5000.0 nMPMID25254640BindingDB,ChEMBL
IC50<10000.0 nM, NoneBindingDB,ChEMBL

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