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GPCR

NameFormyl peptide receptor-related sequence 1
SpeciesMus musculus (Mouse)
GeneFpr-s1
SynonymFPRL2
Lipoxin A4 receptor
LXA4 receptor
LXA4-R
Lxa4r
[ Show all ]
DiseaseN/A for non-human GPCRs
Length351
Amino acid sequenceMETNYSIPLNGSDVVIYDSTISRVLWILSMVVVSITFFLGVLGNGLVIWVAGFRMPHTVTTIWYLNLALADFSFTATLPFLLVEMAMKEKWPFGWFLCKLVHIAVDVNLFGSVFLIAVIALDRCICVLHPVWAQNHRTVSLARNVVVGSWIFALILTLPLFLFLTTVRDARGDVHCRLSFVSWGNSVEERLNTAITFVTTRGIIRFIVSFSLPMSFVAICYGLITTKIHKKAFVNSSRPFRVLTGVVASFFICWFPFQLVALLGTVWLKEMQFSGSYKIIGRLVNPTSSLAFFNSCLNPILYVFMGQDFQERLIHSLSSRLQRALSEDSGHISDTRTNLASLPEDIEIKAI
UniProtO08790
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3407315
IUPHAR224
DrugBankN/A

Ligand

NameCHEMBL3407845
Molecular formulaC27H51N7O10
IUPAC name(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]-4-methylpentanoic acid
Molecular weight633.744
Hydrogen bond acceptor12
Hydrogen bond donor11
XlogP-5.1
SynonymsBDBM50071956
Inchi KeyMKYWJIIBKPLFSS-PXQJOHHUSA-N
Inchi IDInChI=1S/C27H51N7O10/c1-14(2)9-18(31-26(42)20(12-36)33-22(38)16(29)11-35)24(40)34-21(13-37)25(41)30-17(7-5-6-8-28)23(39)32-19(27(43)44)10-15(3)4/h14-21,35-37H,5-13,28-29H2,1-4H3,(H,30,41)(H,31,42)(H,32,39)(H,33,38)(H,34,40)(H,43,44)/t16-,17-,18-,19-,20-,21-/m0/s1
PubChem CID118730407
ChEMBLCHEMBL3407845
IUPHARN/A
BindingDB50071956
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC509000.0 nMPMID25587631BindingDB,ChEMBL

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