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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Parathyroid hormone/parathyroid hormone-related peptide receptor
Species	Homo sapiens (Human)
Gene	PTH1R
Synonym	PTH1 receptor PTHR PTH/PTHrP type I receptor PTH/PTHr receptor PPR Parathyroid hormone 1 receptor PTHR1 [ Show all ]
Disease	N/A
Length	593
Amino acid sequence	MGTARIAPGLALLLCCPVLSSAYALVDADDVMTKEEQIFLLHRAQAQCEKRLKEVLQRPASIMESDKGWTSASTSGKPRKDKASGKLYPESEEDKEAPTGSRYRGRPCLPEWDHILCWPLGAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWELVPGHNRTWANYSECVKFLTNETREREVFDRLGMIYTVGYSVSLASLTVAVLILAYFRRLHCTRNYIHMHLFLSFMLRAVSIFVKDAVLYSGATLDEAERLTEEELRAIAQAPPPPATAAAGYAGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTVFGWGLPAVFVAVWVSVRATLANTGCWDLSSGNKKWIIQVPILASIVLNFILFINIVRVLATKLRETNAGRCDTRQQYRKLLKSTLVLMPLFGVHYIVFMATPYTEVSGTLWQVQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIKKSWSRWTLALDFKRKARSGSSSYSYGPMVSHTSVTNVGPRVGLGLPLSPRLLPTATTNGHPQLPGHAKPGTPALETLETTPPAMAAPKDDGFLNGSCSGLDEEASGPERPPALLQEEWETVM
UniProt	Q03431
Protein Data Bank	6fj3, 3h3g, 3c4m
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 6fj3.
BioLiP	BL0161387, BL0433539,BL0433540, BL0161388, BL0143680,BL0143682, BL0143681,BL0143683
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1793
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	MLS001002564
Molecular formula	C17H14N2O4
IUPAC name	3-[(3-methoxyphenyl)methyl]-4-oxophthalazine-1-carboxylic acid
Molecular weight	310.309
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	2.3
Synonyms	NCGC00282193-01 3-[(3-methoxyphenyl)methyl]-4-oxidanylidene-phthalazine-1-carboxylic acid AC1M9JRH ZINC3439745 3-[(3-methoxyphenyl)methyl]-4-oxophthalazine-1-carboxylic acid CHEMBL1486272 MCULE-9710387993 SMR000369086 3-[(3-methoxyphenyl)methyl]-4-oxo-1-phthalazinecarboxylic acid BDBM97120 4-keto-3-m-anisyl-phthalazine-1-carboxylic acid cid_2559619 AB00608869-06 Z54190512 3-[(3-methoxyphenyl)methyl]-4-oxo-3,4-dihydrophthalazine-1-carboxylic acid 793713-82-3 HMS2734I08 [ Show all ]
Inchi Key	CXBZVDGOWGPODJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H14N2O4/c1-23-12-6-4-5-11(9-12)10-19-16(20)14-8-3-2-7-13(14)15(18-19)17(21)22/h2-9H,10H2,1H3,(H,21,22)
PubChem CID	2559619
ChEMBL	CHEMBL1486272
IUPHAR	N/A
BindingDB	97120
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	28183.8 nM	PubChem BioAssay data set	ChEMBL

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