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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Gonadotropin-releasing hormone receptor
Species	Rattus norvegicus (Rat)
Gene	Gnrhr
Synonym	luteinizing hormone-releasing hormone (LHRH) receptor luliberin receptor LHRHR LHRH receptor GNRHR1 GnRHR GnRH1 receptor GnRH-R GnRH receptor GnRH I receptor Type I GnRHR [ Show all ]
Disease	N/A for non-human GPCRs
Length	327
Amino acid sequence	MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
UniProt	P30969
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3066
IUPHAR	256
DrugBank	N/A

Ligand

Name	CHEMBL2371354
Molecular formula	C76H102ClN19O13
IUPAC name	(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-6-[bis(ethylamino)methylideneamino]-N-[(2S)-1-[[(2S)-1-[(2S)-2-[(carbamoylamino)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]hexanamide
Molecular weight	1525.22
Hydrogen bond acceptor	15
Hydrogen bond donor	18
XlogP	4.3
Synonyms	N/A
Inchi Key	AGJIRZXQQDCFBO-WHSDUDCYSA-N
Inchi ID	InChI=1S/C76H102ClN19O13/c1-6-81-76(82-7-2)84-33-13-12-20-56(65(100)89-58(36-44(3)4)66(101)88-57(21-14-34-83-74(78)79)73(108)96-35-15-22-64(96)72(107)94-95-75(80)109)87-68(103)60(39-47-26-31-53(99)32-27-47)91-71(106)63(43-97)93-70(105)62(41-51-42-85-55-19-11-10-18-54(51)55)92-69(104)61(38-46-24-29-52(77)30-25-46)90-67(102)59(86-45(5)98)40-48-23-28-49-16-8-9-17-50(49)37-48/h8-11,16-19,23-32,37,42,44,56-64,85,97,99H,6-7,12-15,20-22,33-36,38-41,43H2,1-5H3,(H,86,98)(H,87,103)(H,88,101)(H,89,100)(H,90,102)(H,91,106)(H,92,104)(H,93,105)(H,94,107)(H4,78,79,83)(H3,80,95,109)(H2,81,82,84)/t56-,57+,58+,59-,60+,61-,62-,63+,64+/m1/s1
PubChem CID	118705673
ChEMBL	CHEMBL2371354
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
ED50	0.55 ug injection-1	PMID2447279	ChEMBL
ED50	9.5 ug injection-1	PMID2447279	ChEMBL

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