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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Formyl peptide receptor-related sequence 1
Species	Mus musculus (Mouse)
Gene	Fpr-s1
Synonym	FPRL2 Lipoxin A4 receptor LXA4 receptor LXA4-R Lxa4r N-formyl peptide receptor 2 Fprl1 FPRH1 FPR3 Formyl peptide receptor-like 1 Formyl peptide receptor related sequence 1 FMLPY FMLP-related receptor I FMLP-R-I N-formyl peptide receptor 3 [ Show all ]
Disease	N/A for non-human GPCRs
Length	351
Amino acid sequence	METNYSIPLNGSDVVIYDSTISRVLWILSMVVVSITFFLGVLGNGLVIWVAGFRMPHTVTTIWYLNLALADFSFTATLPFLLVEMAMKEKWPFGWFLCKLVHIAVDVNLFGSVFLIAVIALDRCICVLHPVWAQNHRTVSLARNVVVGSWIFALILTLPLFLFLTTVRDARGDVHCRLSFVSWGNSVEERLNTAITFVTTRGIIRFIVSFSLPMSFVAICYGLITTKIHKKAFVNSSRPFRVLTGVVASFFICWFPFQLVALLGTVWLKEMQFSGSYKIIGRLVNPTSSLAFFNSCLNPILYVFMGQDFQERLIHSLSSRLQRALSEDSGHISDTRTNLASLPEDIEIKAI
UniProt	O08790
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3407315
IUPHAR	224
DrugBank	N/A

Ligand

Name	CHEMBL440917
Molecular formula	C16H12N4O2
IUPAC name	3-benzyl-1-methyl-2,4-dioxopyrido[2,3-d]pyrimidine-6-carbonitrile
Molecular weight	292.298
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	1.3
Synonyms	BDBM50219197 1-Methyl-2,4-dioxo-3-benzyl-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile
Inchi Key	BIVMSUKQESISKU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H12N4O2/c1-19-14-13(7-12(8-17)9-18-14)15(21)20(16(19)22)10-11-5-3-2-4-6-11/h2-7,9H,10H2,1H3
PubChem CID	44371162
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50097567
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	240.0 nM	PMID25549897	BindingDB

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