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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Formyl peptide receptor-related sequence 1
Species	Mus musculus (Mouse)
Gene	Fpr-s1
Synonym	FPRL2 Lipoxin A4 receptor LXA4 receptor LXA4-R Lxa4r N-formyl peptide receptor 2 Fprl1 FPRH1 FPR3 Formyl peptide receptor-like 1 Formyl peptide receptor related sequence 1 FMLPY FMLP-related receptor I FMLP-R-I N-formyl peptide receptor 3 [ Show all ]
Disease	N/A for non-human GPCRs
Length	351
Amino acid sequence	METNYSIPLNGSDVVIYDSTISRVLWILSMVVVSITFFLGVLGNGLVIWVAGFRMPHTVTTIWYLNLALADFSFTATLPFLLVEMAMKEKWPFGWFLCKLVHIAVDVNLFGSVFLIAVIALDRCICVLHPVWAQNHRTVSLARNVVVGSWIFALILTLPLFLFLTTVRDARGDVHCRLSFVSWGNSVEERLNTAITFVTTRGIIRFIVSFSLPMSFVAICYGLITTKIHKKAFVNSSRPFRVLTGVVASFFICWFPFQLVALLGTVWLKEMQFSGSYKIIGRLVNPTSSLAFFNSCLNPILYVFMGQDFQERLIHSLSSRLQRALSEDSGHISDTRTNLASLPEDIEIKAI
UniProt	O08790
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3407315
IUPHAR	224
DrugBank	N/A

Ligand

Name	CHEMBL352034
Molecular formula	C22H19N3O2
IUPAC name	3,5-dibenzyl-1-methylpyrido[2,3-d]pyrimidine-2,4-dione
Molecular weight	357.413
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	3.5
Synonyms	BDBM50219199 1-Methyl-3,5-dibenzyl-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-2,4-dione
Inchi Key	HREWYTQCVRLKBH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H19N3O2/c1-24-20-19(18(12-13-23-20)14-16-8-4-2-5-9-16)21(26)25(22(24)27)15-17-10-6-3-7-11-17/h2-13H,14-15H2,1H3
PubChem CID	44371048
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50097562
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	3800.0 nM	PMID25549897	BindingDB

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