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GPCR

Name	Olfactory receptor 5K1
Species	Homo sapiens (Human)
Gene	OR5K1
Synonym	HTPCRX10 Olfactory receptor OR3-8
Disease	N/A
Length	308
Amino acid sequence	MAEENHTMKNEFILTGFTDHPELKTLLFVVFFAIYLITVVGNISLVALIFTHRRLHTPMYIFLGNLALVDSCCACAITPKMLENFFSENKRISLYECAVQFYFLCTVETADCFLLAAMAYDRYVAICNPLQYHIMMSKKLCIQMTTGAFIAGNLHSMIHVGLVFRLVFCGSNHINHFYCDILPLYRLSCVDPYINELVLFIFSGSVQVFTIGSVLISYLYILLTIFKMKSKEGRAKAFSTCASHFLSVSLFYGSLFFMYVRPNLLEEGDKDIPAAILFTIVVPLLNPFIYSLRNREVISVLRKILMKK
UniProt	Q8NHB7
Protein Data Bank	N/A
GPCR-HGmod model	Q8NHB7
3D structure model	This predicted structure model is from GPCR-EXP Q8NHB7.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3721312
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	21145-77-7
Molecular formula	C18H26O
IUPAC name	1-(3,5,5,6,8,8-hexamethyl-6,7-dihydronaphthalen-2-yl)ethanone
Molecular weight	258.405
Hydrogen bond acceptor	1
Hydrogen bond donor	0
XlogP	5.3
Synonyms	acetyl methyl tetramethyl tetralin AKOS015920154 CCRIS 8496 DSSTox_RID_79772 Ethanone, 1-(5,6,7,8-tetrahydro-3,5,5,6,8,8-hexamethyl-2-naphthalenyl)- (VAN) (9CI) KB-213546 1-(3,5,5,6,8,8-Hexamethyl-5,6,7,8-tetrahydronaphthalen-2-yl);ethanone Musk tonalid 145T777 ST24026857 4CH-007834 W-107569 7-Acetyl-1,1,3,4,4,6-hexamethyl-tetra-hydronaphtalene AHTN AX8157828 CHEMBL3184267 EC 244-240-6 FT-0675293 1,1,3,4,4,6-Hexamethyl-7-acetyl-1,2,3,4-tetrahydronaphthalene KSC492C4B 1-(3,5,5,6,8,8-hexamethyl-6,7-dihydronaphthalen-2-yl)ethanone NSC-19550 2'-Acetonaphthone, 5',6',7',8'-tetrahydro-3',5',5',6',8',8'-hexamethyl- (VAN) Tetralide 6-Acetyl-1,1,2,4,4,7-hexamethyltetralin, >=98% 7-Acetyl-1,1,3,4,4,6-hexamethyltetralin AI3-28517 CAS-21145-77-7 DSSTox_CID_21544 Ethanone, 1-(5,6,7,8-tetrahydro-3,5,5,6,8,8-hexamethyl-2-naphthalenyl)- HSDB 7515 1-(3,5,5,6,8,8-Hexamethyl-5,6,7,8-tetrahydro-2-naphthalenyl)ethanone # MCULE-5128561438 1-(5,6,7,8-Tetrahydro-3,5,5,6,8,8-hexamethyl-2-naphthyl)ethan-1-one S-5529 2-Acetyl-3,5,5,6,8,8-hexamethyl-5,6,7,8- tetrahydronaphthalene Tox21_301256 6-acetyl-1,1,2,4,4,7-hexamethyltetraline AC1Q5D0Z AHMT AN-17860 CHEBI:88666 DTXSID7041544 Ethanone,6,7,8-tetrahydro-3,5,5,6,8,8-hexamethyl-2-naphthalenyl)- (VA KS-00000HC4 1-(3,5,5,6,8,8-hexamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethan-1-one NCGC00255431-01 1506-02-1 STL195398 6-Acetyl-1,1,2,4,4,7-hexamethyl-1,2,3,4-tetrahydronaphthalene W-109114 7-Acetyl-1,1,3,4,4,6-hexamethyltetra-hydronaphtalene AHTN (Tonalide) BBL018868 CTK3J2140 EINECS 216-133-4 FT-0688135 1-(1,1,2,4,4,7-hexamethyltetralin-6-yl)ethanone LS-67597 1-(5,6,7,8-tetrahydro-3,5,5,6,8,8-hexamethyl-2-naphthalenyl)-ethanone NSC19550 2'-Acetonaphthone, 5',6',7',8'-tetrahydro-3',5',5',6',8',8'-hexamethyl- (VAN) (8CI) Tonalid 6-Acetyl-1,1,2,4,4,7-hexamethyltetralin, AldrichCPR 7-Acetyl-1,3,4,4,6-hexamethyltetrahydronaphthalene AK-72913 CCRIS 8403 DSSTox_GSID_41544 Ethanone, 1-(5,6,7,8-tetrahydro-3,5,5,6,8,8-hexamethyl-2-naphthalenyl)- (VAN) Jsp004326 1-(3,5,5,6,8,8-Hexamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)ethanone MolPort-000-707-361 131433-13-1 SCHEMBL110818 TR-009939 7-Acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthalene Acetyl hexamethyl tetralin AHMT (perfume) AN-19712 EC 216-133-4 fixolide (+/-)-1-(3,5,5,6,8,8-hexamethyl-5,6,7,8-tetrahydro-2-naphthalenyl)-1-ethanone KS-00000ZD4 1-(3,5,5,6,8,8-hexamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethanone NSC 19550 2'-Acetonaphthone, 5',6',7',8'-tetrahydro-3',5',5',6',8',8'-hexamethyl- Tentarome 6-Acetyl-1,1,2,4,4,7-hexamethyltetralin W4412 7-Acetyl-1,1,3,4,4,6-hexamethyltetrahydronaphthalene AHTN 10 microg/mL in Cyclohexane BR-72913 DNRJTBAOUJJKDY-UHFFFAOYSA-N EINECS 244-240-6 GS-4166 1-(3,5,5,6,8,8-Hexamethyl-5,6,7,8-tetrahydro-2-naphthalenyl)ethanone LS-67598 1-(5,6,7,8-Tetrahydro-3,5,5,6,8,8-hexamethyl-2-naphthalenyl)ethan- one RT-000301 2'-Acetonaphthone,6',7',8'-tetrahydro-3',5',5',6',8',8'-hexamethyl- Tonalide 6-Acetyl-1,1,2,4,4,7-hexamethyltetralin, analytical standard AC1L3HVI [ Show all ]
Inchi Key	DNRJTBAOUJJKDY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H26O/c1-11-8-16-15(9-14(11)13(3)19)17(4,5)10-12(2)18(16,6)7/h8-9,12H,10H2,1-7H3
PubChem CID	89440
ChEMBL	CHEMBL3184267
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	75.0 %	None	ChEMBL

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