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GLASS

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GPCR

Name	Prolactin-releasing peptide receptor
Species	Homo sapiens (Human)
Gene	PRLHR
Synonym	PrRP receptor hGR3 GPR10 G-protein coupled receptor 10 G protein-coupled receptor 10 PrRPR [ Show all ]
Disease	N/A
Length	370
Amino acid sequence	MASSTTRGPRVSDLFSGLPPAVTTPANQSAEASAGNGSVAGADAPAVTPFQSLQLVHQLKGLIVLLYSVVVVVGLVGNCLLVLVIARVRRLHNVTNFLIGNLALSDVLMCTACVPLTLAYAFEPRGWVFGGGLCHLVFFLQPVTVYVSVFTLTTIAVDRYVVLVHPLRRRISLRLSAYAVLAIWALSAVLALPAAVHTYHVELKPHDVRLCEEFWGSQERQRQLYAWGLLLVTYLLPLLVILLSYVRVSVKLRNRVVPGCVTQSQADWDRARRRRTFCLLVVIVVVFAVCWLPLHVFNLLRDLDPHAIDPYAFGLVQLLCHWLAMSSACYNPFIYAWLHDSFREELRKLLVAWPRKIAPHGQNMTVSVVI
UniProt	P49683
Protein Data Bank	N/A
GPCR-HGmod model	P49683
3D structure model	This predicted structure model is from GPCR-EXP P49683.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1681611
IUPHAR	337
DrugBank	N/A

Ligand

Name	SCHEMBL435078
Molecular formula	C28H28ClN5O3
IUPAC name	2-[[1-(4-chlorophenyl)-2-methylpropyl]amino]-6-(isoquinoline-3-carbonyl)-3-methoxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one
Molecular weight	518.014
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	4.3
Synonyms	BDBM195727 US9206173, 2489 CHEMBL3899966
Inchi Key	BYPRTZBNLFRCBD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C28H28ClN5O3/c1-17(2)25(18-8-10-21(29)11-9-18)32-28-31-23-12-13-33(16-22(23)26(35)34(28)37-3)27(36)24-14-19-6-4-5-7-20(19)15-30-24/h4-11,14-15,17,25H,12-13,16H2,1-3H3,(H,31,32)
PubChem CID	66685558
ChEMBL	CHEMBL3899966
IUPHAR	N/A
BindingDB	195727
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Ki	26.0 nM	, None	BindingDB,ChEMBL

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