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GPCR

Name	Alpha-1A adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA1A
Synonym	alpha1a ADRA1C ADRA1L1 adrenergic alpha 1c receptor adrenergic receptor alpha 1c adrenergic receptor, alpha 1a alpha 1A-adrenoceptor alpha 1A-adrenoreceptor alpha1c alpha 1C-adrenergic receptor alpha-1A adrenergic receptor Alpha-1A adrenoceptor Alpha-1A adrenoreceptor Alpha-1C adrenergic receptor Alpha-adrenergic receptor 1c alpha1A-adrenoceptor [ Show all ]
Disease	Urinary incontinence Benign prostatic hyperplasia Cognitive disorders Female sexual dysfunction Glaucoma Hypertension Major depressive disorder Pain Post-traumatic stress disorder Prostate cancer; Benign prostatic hyperplasia Prostate disease Prostate hyperplasia Stress urinary incontinence Unspecified [ Show all ]
Length	466
Amino acid sequence	MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCTTARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV
UniProt	P35348
Protein Data Bank	N/A
GPCR-HGmod model	P35348
3D structure model	This predicted structure model is from GPCR-EXP P35348.
BioLiP	N/A
Therapeutic Target Database	T92609
ChEMBL	CHEMBL229
IUPHAR	22
DrugBank	BE0000501

Ligand

Name	diazepam
Molecular formula	C16H13ClN2O
IUPAC name	7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one
Molecular weight	284.743
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	3.0
Synonyms	Disopam NCGC00178168-02 DSSTox_RID_75566 Neurolytril EINECS 207-122-5 Novodipam Faustan, Paceum Gubex Placidox 10 Iazepam Prozepam Kiatrium Radizepam Lembrol Ruhsitus Mandrozep Diazepan Methyldiazepinone, pharmaceutical Azedipamin Seduksen Diazepam [USAN:INN:BAN:JAN] Best [Pharaceutical] Sibazone Diazepamu [Polish] BSPBio_003279 Spectrum4_000576 1-Methyl-5-phenyl-7-chloro-1,4-benzodiazepin-2-one CAS-439-14-5 Tox21_113071 53320-84-6 CHEBI:49575 Tranquo-puren 7-Chloro-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one D00293 Valeo 7-Chloro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one Diaceplex Vanconin AC-10561 Diastat (TN) Winii An-Ding Apaurin S.A. R.L Diazepam Fabra MLS001424086 Domalium NCGC00260007-01 Duksen Nixtensyn Euphorin P NSC-77518 FT-0632135 Paranten HMS503A15 Plidan Jinpanfan Q-Pam Relanium LA 111 Reliver Lizan Mentalium Diazetard Diazepam Nordic BCP23002 Serenamin Diazepam, United States Pharmacopeia (USP) Reference Standard BIDD:GT0105 Sipam Calmaven Stesolin 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-1-methyl-5-phenyl- CCG-100997 Tranimul 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H -1,4-benzodiazepin-2-one Chuansuan Umbrium 7-Chloro-1-methyl-5-phenyl-1,4-benzodiazepin-2-one DB00829 Valium 7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one. Diapam Vazepam Alboral Diatran WY-3467 Ansiolin Diazepam 0.1 mg/ml in Methanol Armonil SAM001246536 Dipaz NC00247 DSSTox_CID_406 Nervium DZP Novazam Faustal Oprea1_126223 Gradual Paxel HY-17027 Pomin KBio3_002780 Quiatril La-Iii Ro 5-2807 Mandro Diazepamum Methyldiazepinone Sedapam Diazepam solution, 1.0 mg/mL in methanol, analytical standard, for drug analysis Bensedin Setonil Diazepam-ratiopharm Britazepam Sonacon (Z)-7-chloro-1-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one Calmod Tensium 5-24-04-00300 (Beilstein Handbook Reference) Cercine Tranquase 7-Chloro-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepine CS-0653 Usempax ap 7-chloro-1-methyl-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one Desloneg Valrelease AAOVKJBEBIDNHE-UHFFFAOYSA-N Diaquel Vivol Amiprol Diazemuls ZINC6427 Anxicalm Diazepam Desitin Atensine DivK1c_000967 NCGC00178168-03 DTXSID4020406 NINDS_000967 Elcion CR NSC 169897 Freudal Pacitran HMS2051N04 Placidox 2 IDI1_000967 Psychopax Kratium Relaminal Levium MCULE-8990989144 Diazepan leo Metil Gobanal Baogin Seduxen Diazepam [USAN:USP:INN:BAN:JAN] Betapam Sico Relax C-17931 Spectrum5_001890 11100-37-1 Caudel Tox21_113071_1 7 -chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one Tranquo-tablinen 7-chloro-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one D07JVL Valiquid 7-Chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2(1H)-one Dialag Vatran AC1L1EZE Diastat Acudial WLN: T67 GNV JN IHJ CG G1 KR Anlin Diazepam (intranasal, epilepsy) Apo-diazepam S.a. r.l. Diazepam for system suitability, European Pharmacopoeia (EP) Reference Standard Mono (2-ethylhexyl) phthalate Doval Nellium Dupin Noan Eurosan NSC169897 Gewacalm Parzam Horizon Plumiaz Kabivitrum Q3JTX2Q7TU LA III Renborin Lovium Metamidol Dienpax Saromet Diazepam Rectubes BCP9000199 Serenzin Diazepam-Eurogenerics BIDD:PXR0158 SMR000058398 Calmocitene STK735517 CCRIS 6009 Trankinon 7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one Condition UNII-Q3JTX2Q7TU 7-chloro-1-methyl-5-phenyl-1H-1,4-benzodiazepine-2(3H)on DEA No. 2765 Valium (TN) A3662/0155188 Diapax Velium Aliseum Diazapam ZB000640 Ansiolisina Diazepam 1.0 mg/ml in Methanol Arzepam Dipezona NCGC00178168-01 DSSTox_GSID_20406 neurolytr il e-Pam Novo-Dipam Faustan Ortopsique GTPL3364 Paxum I06-0194 Pro pam KBioGR_001012 Quievita Lamra Ro-52807 Mandro-Zep Diazepamum [INN-Latin] Methyldiazepinone (pharmaceutical) Atilen Sedipam Diazepam Stada Benzopin Sibazon Diazepamu BRN 0754371 Spectrum3_001780 1-Methyl-5-phenyl-7-chloro-1,3-dihydro-2H-1,4-benzodiazepin-2-one Calmpose Tensopam Ceregulart Tranquirit 7-Chloro-1-methyl-5-3H-1,4-benzodiazepin-2(1H)-one D-Pam Valaxona 7-Chloro-1-methyl-5-phenyl-2-oxo-2,3-dihydro-1H-benzo[f]-1,4-diazepine Diacepan Valuzepam AB02310 Diastat W-5055 AN-23449 Diazemulus Zipan Anxionil Diazepam Elmu MLS000759402 Dizac NCGC00178168-04 Ducene Nivalen Eridan NSC-169897 Frustan Paralium HMS3393N04 Placidox 5 InChI=1/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H Q-pam Kratium 2 Relanium Liberetas Medipam Diazepin BCP0726000176 Serenack Diazepam, European Pharmacopoeia (EP) Reference Standard Bialzepam Simasedan C06948 Stesolid 2H-1, 7-chloro-1,3-dihydro-1-methyl-5-phenyl- CC-26451 Tox21_202458 7-chloranyl-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one CHEMBL12 Trazepam 7-chloro-1-methyl-5-phenyl-1,3-dihydro-[1,4]benzodiazepin-2-one D0Y1YC Valitran 7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one Dialar Vazen AKOS003367969 Diastat, Valium Wy 3467 Ansilive Diazepam (JP17/USP/INN) Apozepam S.A.R.L. Diazepam Intensol Morosan Drenian Nerozen Duxen Notense Evacalm NSC77518 Gihitan Paxate HSDB 3057 Pms-Diazepam KBio1_000967 Quetinil LA-111 Ro 5-2805 LS-122 Methyl diazepinone Dipam SCHEMBL21442 Diazepam solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material BDBM50000766 Servizepam Diazepam-Lipuro BRD-K16508793-001-01-8 Solis Calmociteno T-quil 439-14-5 Centrazepam Tranqdyn 7-chloro-1-methyl-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one CPD000058398 Unisedil 7-Chloro-1-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one Desconet Valium R A826456 Diapine Vival Alupram Diazem Zepaxid Antenex Diazepam Dak Assival [ Show all ]
Inchi Key	AAOVKJBEBIDNHE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3
PubChem CID	3016
ChEMBL	CHEMBL12
IUPHAR	3364
BindingDB	50000766
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	85700.0 nM	PMID10565838	IUPHAR

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