Zhang Lab

University of Michigan

Home Research COVID-19 Services Publications People Teaching Job Opening News Forum Lab Only

Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●DMFold ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
Go back to previous page.

GPCR

Name	Cannabinoid receptor 2
Species	Homo sapiens (Human)
Gene	CNR2
Synonym	Peripheral cannabinoid receptor rCB2 hCB2 cannabinoid receptor 2 (macrophage) cannabinoid receptor 2 (spleen) CB-2 CB2 CB2 receptor CB2-R CX5 [ Show all ]
Disease	Immune disorder Inflammatory bowel disease Inflammatory disease Neuropathic pain Osteoporosis Pain Atopic dermatitis Rheumatoid arthritis [ Show all ]
Length	360
Amino acid sequence	MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
UniProt	P34972
Protein Data Bank	5zty
GPCR-HGmod model	P34972
3D structure model	This structure is from PDB ID 5zty.
BioLiP	BL0438927
Therapeutic Target Database	T37693
ChEMBL	CHEMBL253
IUPHAR	57
DrugBank	BE0000095

Ligand

Name	335161-24-5
Molecular formula	C24H22FNO
IUPAC name	[1-(5-fluoropentyl)indol-3-yl]-naphthalen-1-ylmethanone
Molecular weight	359.444
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	5.9
Synonyms	(1-(5-fluoropentyl)-1H-indol-3-yl)(naphthalen-1-yl)methanone;AM-2201 AB1004336 AM-2201 ((1-(5-Fluoropentyl)indol-3-yl)(naphthalen-1-yl)methanone) 1.0 mg/ml in Acetonitrile JWH 2201 [1-(5-Fluoropentyl)-1H-indol-3-yl]-1-naphthalenylmethanone 1-(5-fluoropentyl)-3-(1-naphthoyl)indole ALQFAGFPQCBPED-UHFFFAOYSA-N AN-28796 DB-030004 TC-134856 [1-(5-fluoropentyl)indol-3-yl]-naphthalen-1-ylmethanone AM-2201 ((1-(5-Fluoropentyl)indol-3-yl)(naphthalen-1-yl)methanone) BDBM50088439 FT-0661542 Z-3277 (1-(5-Fluoropentyl)-3-(1-naphthoyl)indole) ABP000764 AM-2201/AM2201/ CHEMBL3526578 SCHEMBL15703451 [1-(5-Fluoropentyl)-3-(naphthalen-1-oyl)indole AM 2201 ANW-46111 DEA No. 7201 UNII-TBJ0966F1O (1-(5-Fluoropentyl)-1H-indol-3-yl)(naphthalen-1-yl)methanone A20540 AM-2201 ((1-(5-Fluoropentyl)indol-3-yl)(naphthalen-1-yl)methanone) 0.1 mg/ml in Acetonitrile CCG-208747 GTPL9705 ZINC1550858 (1-(5-Fluoropentyl)indol-3-yl)(naphthalen-1-yl)methanone AKOS015950753 AM2201 CTK8B4765 TBJ0966F1O [1-(5-fluoropentyl)indol-3-yl]-(1-naphthyl)methanone AM-2201 API0007720 DTXSID50187158 W5518 [ Show all ]
Inchi Key	ALQFAGFPQCBPED-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H22FNO/c25-15-6-1-7-16-26-17-22(20-12-4-5-14-23(20)26)24(27)21-13-8-10-18-9-2-3-11-19(18)21/h2-5,8-14,17H,1,6-7,15-16H2
PubChem CID	53393997
ChEMBL	CHEMBL3526578
IUPHAR	9705
BindingDB	50088439
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	58.8 nM	PMID25921407	IUPHAR

zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218