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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Formyl peptide receptor-related sequence 1
Species	Mus musculus (Mouse)
Gene	Fpr-s1
Synonym	FPRL2 Lipoxin A4 receptor LXA4 receptor LXA4-R Lxa4r N-formyl peptide receptor 2 Fprl1 FPRH1 FPR3 Formyl peptide receptor-like 1 Formyl peptide receptor related sequence 1 FMLPY FMLP-related receptor I FMLP-R-I N-formyl peptide receptor 3 [ Show all ]
Disease	N/A for non-human GPCRs
Length	351
Amino acid sequence	METNYSIPLNGSDVVIYDSTISRVLWILSMVVVSITFFLGVLGNGLVIWVAGFRMPHTVTTIWYLNLALADFSFTATLPFLLVEMAMKEKWPFGWFLCKLVHIAVDVNLFGSVFLIAVIALDRCICVLHPVWAQNHRTVSLARNVVVGSWIFALILTLPLFLFLTTVRDARGDVHCRLSFVSWGNSVEERLNTAITFVTTRGIIRFIVSFSLPMSFVAICYGLITTKIHKKAFVNSSRPFRVLTGVVASFFICWFPFQLVALLGTVWLKEMQFSGSYKIIGRLVNPTSSLAFFNSCLNPILYVFMGQDFQERLIHSLSSRLQRALSEDSGHISDTRTNLASLPEDIEIKAI
UniProt	O08790
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3407315
IUPHAR	224
DrugBank	N/A

Ligand

Name	lipoxin A4
Molecular formula	C20H32O5
IUPAC name	(5S,6R,7E,9E,11Z,13E,15S)-5,6,15-trihydroxyicosa-7,9,11,13-tetraenoic acid
Molecular weight	352.471
Hydrogen bond acceptor	5
Hydrogen bond donor	4
XlogP	3.1
Synonyms	(5S,6R,15S)-trihydroxy-7,9,13-trans-11-cis-eicosatetraenoic acid 5(S),6(R),15(S)-trihydroxyeicosa-7E,9E,11Z,13E-tetraenoic acid 6R-LXA4 CHEBI:6498 HMS3402E20 NCGC00161280-01 (5S,6R,7E,9E,11Z,13E,15S)-5,6,15-trihydroxyicosa-7,9,11,13-tetraenoic acid 5S,6R,15S-trihydroxy-7,9,13-trans-11-cis-eicosatetraenoic acid AC1NQXRP D0V3DQ SR-01000946984 5S,6R-LipoxinA4 C040527000 HMS1791E20 LXA4 [3H]-LXA4 (5S,6R,7E,9E,11Z,13E,15S)-5,6,15-trihydroxy-7,9,11,13-eicosatetraenoic acid 5,6,15-triHETE 89663-86-5 CHEMBL392438 IDI1_033848 NCGC00161280-02 (7E,9E,11Z,13E)-(5S,6R,15S)-5,6,15-Trihydroxyicosa-7,9,11,13-tetraenoate 5S,6R,15S-Trihydroxy-7E,9E,11Z,13E-eicosatetraenoate BML1-E11 GTPL1034 Lipoxin A4, ethanol solution SR-01000946984-1 (5S,6R,15S)-Trihydroxy-(7E,9E,11Z,13E)-Eicosatetraenoic acid 1833AH 5S,6S-Lipoxin A4 C06314 HMS1989E20 MFCD00065845 [3H]LXA4 (5S,6R,7E,9E,11Z,13E,15S)-5,6,15-trihydroxyeicosa-7,9,11,13-tetraenoic acid 5,6,15-trihydroxy-7,9,11,13-eicosatetraenoic acid 94292-81-6 D0R1FZ Lipoxin A NCGC00161280-03 (7E,9E,11Z,13E)-(5S,6R,15S)-5,6,15-Trihydroxyicosa-7,9,11,13-tetraenoic acid 5S,6R,15S-trihydroxy-7E,9E,11Z,13E-Eicosatetraenoic acid BSPBio_001378 HMS1361E20 LMFA03040001 ZINC4097074 [ Show all ]
Inchi Key	IXAQOQZEOGMIQS-SSQFXEBMSA-N
Inchi ID	InChI=1S/C20H32O5/c1-2-3-8-12-17(21)13-9-6-4-5-7-10-14-18(22)19(23)15-11-16-20(24)25/h4-7,9-10,13-14,17-19,21-23H,2-3,8,11-12,15-16H2,1H3,(H,24,25)/b6-4-,7-5+,13-9+,14-10+/t17-,18+,19-/m0/s1
PubChem CID	5280914
ChEMBL	N/A
IUPHAR	1034
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Kd	1.51356 nM	PMID9151906	IUPHAR

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