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GPCR

Name	Beta-3 adrenergic receptor
Species	Mus musculus (Mouse)
Gene	Adrb3
Synonym	beta3-adrenoceptor beta3-adrenergic receptor beta-3 adrenoreceptor Beta-3 adrenoceptor ADRB beta 3-AR atypical beta-adrenoceptor adrenergic receptor Adrb-3 [ Show all ]
Disease	N/A for non-human GPCRs
Length	400
Amino acid sequence	MAPWPHRNGSLALWSDAPTLDPSAANTSGLPGVPWAAALAGALLALATVGGNLLVIIAIARTPRLQTITNVFVTSLAAADLVVGLLVMPPGATLALTGHWPLGETGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGTLVTKRRARAAVVLVWIVSAAVSFAPIMSQWWRVGADAEAQECHSNPRCCSFASNMPYALLSSSVSFYLPLLVMLFVYARVFVVAKRQRHLLRRELGRFSPEESPPSPSRSPSPATGGTPAAPDGVPPCGRRPARLLPLREHRALRTLGLIMGIFSLCWLPFFLANVLRALAGPSLVPSGVFIALNWLGYANSAFNPVIYCRSPDFRDAFRRLLCSYGGRGPEEPRAVTFPASPVEARQSPPLNRFDGYEGARPFPT
UniProt	P25962
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4030
IUPHAR	30
DrugBank	N/A

Ligand

Name	norepinephrine
Molecular formula	C8H11NO3
IUPAC name	4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol
Molecular weight	169.18
Hydrogen bond acceptor	4
Hydrogen bond donor	4
XlogP	-1.2
Synonyms	GTPL505 4786-EP2287166A2 Noreinefrina [INN-Spanish] IDI1_000230 4786-EP2308873A1 Norepinephrine [INN:JAN] l-1-(3,4-Dihydroxyphenyl)-2-aminoethanol 51-40-1 (l-tartrate (1:1)) Pharmakon1600-01500436 Levarterenolo Adrenor SMR000058585 (-)-(R)-Norepinephrine API0003193 STK503776 (-)-Norepinephrine, >=98%, crystalline C-05156 X4W3ENH1CV 025N592 Levonoradrenaline CHEMBL1437 1,2-Benzenediol,4-(2-amino-1-hydroxyethyl)- NCGC00159406-04 D0R2UN 21779-EP2298731A1 NCGC00255328-01 DSSTox_RID_77004 4-[(1R)-2-amino-1-hydroxy-ethyl]benzene-1,2-diol Noradrenalina Noradrenaline (JP15) HMS2091J08 4786-EP2305644A1 KBio2_004057 4786-EP2314571A2 Norepirenamine L-alpha-(aminomethyl)-3,4-dihydroxybenzyl alcohol AB00052424-06 SBI-0050082.P003 AKOS015854572 Spectrum2_001064 (-)-Arterenol free base Benzyl alcohol, .alpha.-(aminomethyl)-3,4-dihydroxy-, (+)- to_000024 (R)-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol CAS-51-41-2 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)- LS-42676 D-(-)-Noradrenaline 21779-EP2272847A1 NCGC00159406-07 DB00368 21779-EP2311828A1 Nor adrenalin (TN) EINECS 200-096-6 4786-EP2270011A1 4786-EP2287163A1 Norartrinal HY-13715 4786-EP2305678A1 Norepinephrine Noradrenalin KBioGR_000635 PDSP1_001111 L-Norepinephrine AC1L96ZT SFLSHLFXELFNJZ-QMMMGPOBSA-N (+)-Noradrenaline AN-24392 Spectrum5_001068 (-)-NORADRENALINE/ 1,?2-?Benzenediol, 4-?[(1R)?-?2-?amino-?1-?hydroxyethyl]?- BRN 4231961 UNII-X4W3ENH1CV (R)-Noradrenaline Levoarterenol CHEBI:18357 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-(9CI) MLS006010883 D00076 21779-EP2287166A2 NCGC00159406-10 DSSTox_CID_3378 21779-EP2377510A1 Noradrenalin FT-0658803 HMS1920B08 4786-EP2292620A2 norepinefrina KBio1_000230 4786-EP2308875A1 norepinephrinum l-2-Amino-1-(3,4-dihydroxyphenyl)ethanol 51-41-2 PubChem6074 AJ-09755 SPBio_001048 (-)-alpha-(Aminomethyl)protocatechuyl alcohol Arterenol Sympathin E (R)-( C)-Norepinephrine C-4015 xi-Norepinephrine 1,2-Benzenediol, 4-((1R)-2-amino-1-hydroxyethyl)- Levonorepinephrine CS-0007744 138-65-8 NCGC00159406-05 D53D5E3A-2360-4CA9-8031-6C2CD4062FD5 21779-EP2298742A1 NINDS_000230 DTXSID5023378 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol Noradrenalina [Italian] 4786-EP2280010A2 Noradrenaline (JP17) HMS500L12 4786-EP2305648A1 Norepinephrine (INN) KBio2_006625 4786-EP2316836A1 NSC-757246 L-arterenol AB00052424_07 SC-04955 Aktamin Spectrum3_000520 (-)-NORADRENALINE Benzyl alcohol, alpha-(aminomethyl)-3,4-dihydroxy-, (-)- TR-005105 (R)-4-(2-Amino-1-hydroxyethyl)benzene-1,2-diol CC-33071 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)- (9CI) LT03330026 d-Arterenol 21779-EP2284170A1 NCGC00159406-08 DermX 21779-EP2311835A1 Nor-adrenaline FCH920095 4786-EP2287165A2 Noreinefrina I01-15661 4786-EP2308864A1 Norepinephrine [INN:BAN:JAN] KBioSS_001489 PDSP2_001095 Levarterenol Adrenaline Impurity SGCUT00123 (+)-Norepinephrine ANW-74377 Spectrum_001009 (-)-Norepinephrine BSPBio_002079 W-105896 (R)-Norepinephrine Levonor 1,2-Benzenediol, 4-[(1R)-2-amino-1-hydroxyethyl]- NCGC00159406-03 D07MOX 21779-EP2292620A2 NCGC00159406-11 DSSTox_GSID_23378 4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol Noradrenalin, l- FT-0679201 noradrenaline HMS2089E18 4786-EP2298776A1 NOREPINEPHIRINE KBio2_001489 4786-EP2311831A1 Norepinephrinum [INN-Latin] L-3,4-dihydroxyphenylethanolamine 66197-73-7 R-norepinephrine AKOS006345192 SPECTRUM1500436 (-)-Arterenol BDBM50029051 Tox21_301944 (R)-(-)-Norepinephrine C00547 ZINC57624 1,2-Benzenediol, 4-((R)-2-amino-1-hydroxyethyl)- Levophed CTK4C1344 21779-EP2269990A1 NCGC00159406-06 21779-EP2305669A1 Nor adrenalin Ecteinascidins 4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol 4786-EP2284171A1 Noradrenalinum HSDB 7772 4786-EP2305677A1 Norepinephrine l-Tartrate (1:1) KBio3_001579 4899-05-2 NSC757246 L-Noradrenaline AB00052424_08 SCHEMBL2609 ALBB-006229 Spectrum4_000078 (-)-NORADRENALINE/ 1,?2-?Benzenediol, 4-?[(1R)?-?2 bmse000404 UNII-K294OAI79V component SFLSHLFXELFNJZ-QMMMGPOBSA-N (R)-4-(2-Amino-1-hydroxyethyl)catechol Levarterenolo [DCIT] CCG-40104 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-(-)- MFCD00025592 d-Norepinephrine 21779-EP2287165A2 NCGC00159406-09 DivK1c_000230 21779-EP2314571A2 Nor-Epirenan FT-0603221 [ Show all ]
Inchi Key	SFLSHLFXELFNJZ-QMMMGPOBSA-N
Inchi ID	InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1
PubChem CID	439260
ChEMBL	CHEMBL1437
IUPHAR	505
BindingDB	50029051
DrugBank	DB00368
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	158489.0 nM	PMID14744619	IUPHAR

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