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Name | Gonadotropin-releasing hormone receptor |
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Species | Rattus norvegicus (Rat) |
Gene | Gnrhr |
Synonym | luteinizing hormone-releasing hormone (LHRH) receptor luliberin receptor LHRHR LHRH receptor GNRHR1 [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 327 |
Amino acid sequence | MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL |
UniProt | P30969 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3066 |
IUPHAR | 256 |
DrugBank | N/A |
Name | CHEMBL413862 |
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Molecular formula | C69H84ClN13O12 |
IUPAC name | (2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-naphthalen-2-ylpropanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]-N-[(2R)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide |
Molecular weight | 1322.96 |
Hydrogen bond acceptor | 13 |
Hydrogen bond donor | 13 |
XlogP | 5.4 |
Synonyms | N/A |
Inchi Key | AIWZVWLDVSCITF-ISSAMJDKSA-N |
Inchi ID | InChI=1S/C69H84ClN13O12/c1-39(2)31-53(61(88)77-52(15-9-29-74-69(72)73)68(95)83-30-10-16-59(83)67(94)75-40(3)60(71)87)78-64(91)57(37-45-18-24-47-12-6-8-14-49(47)33-45)80-63(90)55(35-43-21-27-51(86)28-22-43)81-66(93)58(38-84)82-65(92)56(34-42-19-25-50(70)26-20-42)79-62(89)54(76-41(4)85)36-44-17-23-46-11-5-7-13-48(46)32-44/h5-8,11-14,17-28,32-33,39-40,52-59,84,86H,9-10,15-16,29-31,34-38H2,1-4H3,(H2,71,87)(H,75,94)(H,76,85)(H,77,88)(H,78,91)(H,79,89)(H,80,90)(H,81,93)(H,82,92)(H4,72,73,74)/t40-,52+,53+,54+,55+,56+,57+,58+,59+/m1/s1 |
PubChem CID | 44330602 |
ChEMBL | CHEMBL413862 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Activity | 3.8 - | PMID7636852 | ChEMBL |
Activity | 6.0 - | PMID7636852 | ChEMBL |
Activity | 14.0 - | PMID7636852 | ChEMBL |
Activity | 29.0 - | PMID7636852 | ChEMBL |
Activity | 39.0 - | PMID7636852 | ChEMBL |
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