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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Somatostatin receptor type 3
Species	Homo sapiens (Human)
Gene	SSTR3
Synonym	SSR-28 SS3R SS3-R SS-3-R SRIF1C somatostatin receptor 28 SST3 receptor [ Show all ]
Disease	N/A
Length	418
Amino acid sequence	MDMLHPSSVSTTSEPENASSAWPPDATLGNVSAGPSPAGLAVSGVLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRVLLRPSRRVRSQEPTVGPPEKTEEEDEEEEDGEESREGGKGKEMNGRVSQITQPGTSGQERPPSRVASKEQQLLPQEASTGEKSSTMRISYL
UniProt	P32745
Protein Data Bank	N/A
GPCR-HGmod model	P32745
3D structure model	This predicted structure model is from GPCR-EXP P32745.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2028
IUPHAR	357
DrugBank	BE0003529

Ligand

Name	CHEMBL3287627
Molecular formula	C20H20Cl2F2N2O
IUPAC name	N-[(1R,2S)-2-[(3,4-dichlorophenyl)methylamino]cyclohexyl]-3,4-difluorobenzamide
Molecular weight	413.29
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	5.1
Synonyms	BDBM50021073
Inchi Key	AAZOQKAGKZABTI-RBUKOAKNSA-N
Inchi ID	InChI=1S/C20H20Cl2F2N2O/c21-14-7-5-12(9-15(14)22)11-25-18-3-1-2-4-19(18)26-20(27)13-6-8-16(23)17(24)10-13/h5-10,18-19,25H,1-4,11H2,(H,26,27)/t18-,19+/m0/s1
PubChem CID	90644991
ChEMBL	CHEMBL3287627
IUPHAR	N/A
BindingDB	50021073
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Activity	100.0 %	PMID24944745	ChEMBL
EC50	4.5 nM	PMID24944745	BindingDB
EC50	4.53 nM	PMID24944745	ChEMBL
Ki	4.48 nM	PMID24944745	ChEMBL
Ki	4.5 nM	PMID24944745	BindingDB

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