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GPCR

Name	D(2) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD2
Synonym	dopamine receptor 2 Dopamine D2 receptor D2R D2A and D_2B D2(415) and D₂₍₄₄₄₎ D2 receptor [ Show all ]
Disease	Substance dependence Major depressive disorder Maintain blood pressure in hypotensive states Insomnia Inflammatory disease Inflammatory bowel disease Idiopathic thrombocytopenic purpura Hypertension; Angina pectoris Hypertension Hyperprolactinemia Huntington's disease Glaucoma Gastrointestinal problems Malignant phaeochromocytoma; Benign prostatic hypertrophy; Malignant essential hypertension Migraine headaches Nasal congestion Sexual dysfunction Schizophrenia; Schizoaffective disorders Schizophrenia; Bipolar disorder Schizophrenia Psychotic disorders Psychosis Postpartum haemorrhage Peripheral vasoconstriction; Pulmonary hypertension Parkinson's disease Pain; Inflammatory diseases Ophthalmic disease Non-small cell lung cancer Nausea; Vomiting Fibrosis False perceptions; Bipolar disorder Emesis Chronic obstructive pulmonary disease Cerebrovascular ischaemia Cardiotonic Cardiac failure Bacterial infections Breast cancer Bipolar disorder; Schizophrenia Bipolar disorder Corneal vascularity; Hyperaemia; Itching Asthma; Bronchitis Anxiety disorder Carcinoid syndrome; Acromegaly Advanced stage Parkinson's disease Dermal necrosis Depressive fatigue Alcohol use disorders Allergy Alzheimer disease Hypotension [ Show all ]
Length	443
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
UniProt	P14416
Protein Data Bank	6cm4, 6c38
GPCR-HGmod model	P14416
3D structure model	This structure is from PDB ID 6cm4.
BioLiP	BL0408379, BL0403379
Therapeutic Target Database	T67162
ChEMBL	CHEMBL217
IUPHAR	215
DrugBank	BE0000756

Ligand

Name	methylphenidate
Molecular formula	C14H19NO2
IUPAC name	methyl 2-phenyl-2-piperidin-2-ylacetate
Molecular weight	233.311
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	0.2
Synonyms	Ritalin LA (TN) CS-4657 SBI-0206868.P001 DTXSID5023299 Jornay PM (a.k.a. HLD200) Methyl (2-phenyl-2-(2-piperidyl)acetate) Methyl alpha-phenyl-alpha-2-piperidinylacetate Methylin .alpha.-Phenyl-2-piperidineacetic acid methyl ester METHYLPHENIDATE (SEE ALSO: METHYLPHENIDATE HYDROCHLORIDE, CAS 298-59-9, NTPNO 10266-R) AKOS022506757 MethyPatch BRD-A19585813-003-01-7 phenyl-piperidin-2-yl-acetic acid methyl ester Centedrine (Salt/Mix) CHEMBL796 Ritaline D04999 Equasym (TN) Meridil Methyl .alpha.-phenyl-2-piperidine-acetate Methyl phenidyl acetate Methylin ER 2-Piperidineacetic acid, alpha-phenyl-, methyl ester Methylphenidate [INN:BAN] API0008866 Metilfenidato [Italian] Calocain Riphenidate Concerta, Methylin, Ritalin Rubifen DB00422 HSDB 3126 Metadate ER methyl 2-phenyl-2-piperidin-2-ylacetate methyl phenyl(piperidin-2-yl)acetate Methylphenidan AB01563134_01 Methylphenidatum [INN-Latin] BDBM50062912 NCI-C56280 Centedrin Ritalin (TN) Ritalin SR d-methylphenidate HCl SCHEMBL37178 DUGOZIWVEXMGBE-UHFFFAOYSA-N L001307 Methyl .alpha.-phenyl-.alpha.-(2-piperidyl)acetate methyl alpha-piperid-2-ylphenylacetate Methylin (Salt/Mix) 113-45-1 Methylphenidate (USAN/INN) alpha-Phenyl-2-piperidineacetic acid methyl ester Metilfenidato C 4311 Plimasine Centredin Concerta Ritaline (Salt/Mix) Daytrana FT-0700534 Metadate Methyl .alpha.-phenyl-2-piperidineacetate Methyl phenidylacetate Methylofenidan 298-59-9 (hydrochloride) Methylphenidate [USAN:INN:BAN] Attenta (TN) Motiron (TN) Centedein Ritalin Ritalin LA Cotempla XR-ODT Rubifen (TN) DEA No. 1724 HY-B1091 Metadate ER (TN) Methyl alpha-phenyl-alpha-(2-piperidyl)acetate Methylfenidan AC1L1HJM Methylphenidylacetate hydrochloride Biphentin (TN) Phenidylate Centedrin (Salt/Mix) Ritalin-SR D02PPN Tsentedrin EINECS 204-028-6 LS-565 Methyl .alpha.-phenyl-.alpha.-2-piperidinylacetate Methyl phenidate Methylin (TN) 2-Piperidineacetic acid, .alpha.-phenyl-, methyl ester Methylphenidate HCl alpha-Phenyl-alpha-(2-piperidyl)acetic acid methyl ester Metilfenidato [INN-Spanish] C07196 PMS-Methylphenidate CHEBI:84276 Concerta (TN) Ritcher works Daytrana (TN) GTPL7236 Metadate CD Methyl 2-phenyl-2-(piperidin-2-yl)acetate Methyl phenyl(2-piperidinyl)acetate # Methylphen 4311/B Ciba Methylphenidatum BCP18286 NCGC00248587-01 Centedein (Salt/Mix) Ritalin (Salt/Mix) [ Show all ]
Inchi Key	DUGOZIWVEXMGBE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H19NO2/c1-17-14(16)13(11-7-3-2-4-8-11)12-9-5-6-10-15-12/h2-4,7-8,12-13,15H,5-6,9-10H2,1H3
PubChem CID	4158
ChEMBL	N/A
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID9686407	PDSP

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