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GLASS

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GPCR

Name	Relaxin receptor 2
Species	Homo sapiens (Human)
Gene	RXFP2
Synonym	RXFPR2 RXFP2 relaxin/insulin like family peptide receptor 2 relaxin receptor 2 Relaxin family peptide receptor 2 LGR8 Leucine-rich repeat-containing G-protein coupled receptor 8 leucine-rich repeat-containing G protein-coupled receptor 8 INSL3 receptor GPR106 G-protein coupled receptor affecting testicular descent G-protein coupled receptor 106 [ Show all ]
Disease	N/A
Length	754
Amino acid sequence	MIVFLVFKHLFSLRLITMFFLLHFIVLINVKDFALTQGSMITPSCQKGYFPCGNLTKCLPRAFHCDGKDDCGNGADEENCGDTSGWATIFGTVHGNANSVALTQECFLKQYPQCCDCKETELECVNGDLKSVPMISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNLSHIYFKNFRYCSYAPHVRICMPLTDGISSFEDLLANNILRIFVWVIAFITCFGNLFVIGMRSFIKAENTTHAMSIKILCCADCLMGVYLFFVGIFDIKYRGQYQKYALLWMESVQCRLMGFLAMLSTEVSVLLLTYLTLEKFLVIVFPFSNIRPGKRQTSVILICIWMAGFLIAVIPFWNKDYFGNFYGKNGVCFPLYYDQTEDIGSKGYSLGIFLGVNLLAFLIIVFSYITMFCSIQKTALQTTEVRNCFGREVAVANRFFFIVFSDAICWIPVFVVKILSLFRVEIPDTMTSWIVIFFLPVNSALNPILYTLTTNFFKDKLKQLLHKHQRKSIFKIKKKSLSTSIVWIEDSSSLKLGVLNKITLGDSIMKPVS
UniProt	Q8WXD0
Protein Data Bank	2m96
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 2m96.
BioLiP	BL0278456
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1628482
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	5-[2-(methylsulfanyl)phenyl]-1,3,4-oxadiazol-2-ylhydrosulfide
Molecular formula	C9H8N2OS2
IUPAC name	5-(2-methylsulfanylphenyl)-3H-1,3,4-oxadiazole-2-thione
Molecular weight	224.296
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	2.5
Synonyms	CHEMBL1326901 MLS000695029 6L-608S CTK8F6663 SBB096678 338968-03-9 BDBM47348 MCULE-3023749604 ZINC15924014 5-(2-methylthiophenyl)-1,3,4-oxadiazole-2-thiol 5-[2-(methylsulfanyl)phenyl]-1,3,4-oxadiazole-2-thiol cid_2764158 MolPort-002-345-171 AC1MC9DJ HMS2658F18 SMR000334652 5-(2-(Methylthio)phenyl)-1,3,4-oxadiazole-2-thiol methylsulfanylphenyloxadiazolylhydrosulfide 5-[2-(Methylsulfanyl)phenyl]-1,3,4-oxadiazol-2-yl hydrosulfide 5-[2-(methylthio)phenyl]-3H-1,3,4-oxadiazole-2-thione CTK7B5173 RP12973 AKOS005070836 KS-00001YIO TR-062978 5-(2-methylsulfanylphenyl)-3H-1,3,4-oxadiazole-2-thione [ Show all ]
Inchi Key	FWDJIBHZKZYFRV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C9H8N2OS2/c1-14-7-5-3-2-4-6(7)8-10-11-9(13)12-8/h2-5H,1H3,(H,11,13)
PubChem CID	2764158
ChEMBL	CHEMBL1326901
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	10931.0 nM	PubChem BioAssay data set	ChEMBL

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