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GLASS

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GPCR

Name	N-arachidonyl glycine receptor
Species	Homo sapiens (Human)
Gene	GPR18
Synonym	GPCRW G-protein coupled receptor 18 N-arachidonoyol glycine receptor NAGly receptor GPR18
Disease	N/A
Length	331
Amino acid sequence	MITLNNQDQPVPFNSSHPDEYKIAALVFYSCIFIIGLFVNITALWVFSCTTKKRTTVTIYMMNVALVDLIFIMTLPFRMFYYAKDEWPFGEYFCQILGALTVFYPSIALWLLAFISADRYMAIVQPKYAKELKNTCKAVLACVGVWIMTLTTTTPLLLLYKDPDKDSTPATCLKISDIIYLKAVNVLNLTRLTFFFLIPLFIMIGCYLVIIHNLLHGRTSKLKPKVKEKSIRIIITLLVQVLVCFMPFHICFAFLMLGTGENSYNPWGAFTTFLMNLSTCLDVILYYIVSKQFQARVISVMLYRNYLRSMRRKSFRSGSLRSLSNINSEML
UniProt	Q14330
Protein Data Bank	N/A
GPCR-HGmod model	Q14330
3D structure model	This predicted structure model is from GPCR-EXP Q14330.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2384898
IUPHAR	89
DrugBank	BE0002304

Ligand

Name	CHEMBL3220955
Molecular formula	C13H10F2N2OS
IUPAC name	(2Z)-2-[(2,4-difluorophenyl)methylidene]-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-3-one
Molecular weight	280.293
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	2.8
Synonyms	2-(2,4-Difluorobenzylidene)-2,3,6,7-tetrahydro-5H-imidazo[2,1-b][1,3]thiazine-3-one
Inchi Key	GDDXOHJBSCMDQG-WDZFZDKYSA-N
Inchi ID	InChI=1S/C13H10F2N2OS/c14-9-3-2-8(10(15)7-9)6-11-12(18)17-4-1-5-19-13(17)16-11/h2-3,6-7H,1,4-5H2/b11-6-
PubChem CID	90667467
ChEMBL	CHEMBL3220955
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	11.0 %	MedChemComm, (2014) 5:5:632	ChEMBL
IC50	<10000.0 nM	MedChemComm, (2014) 5:5:632	ChEMBL
Inhibition	6.0 %	MedChemComm, (2014) 5:5:632	ChEMBL

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