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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Trace amine-associated receptor 1
Species	Rattus norvegicus (Rat)
Gene	Taar1
Synonym	TA1 receptor TaR-1 TAR1 Trace amine receptor 1 TRAR1
Disease	N/A for non-human GPCRs
Length	332
Amino acid sequence	MHLCHNSANISHTNSNWSRDVRASLYSLISLIILTTLVGNLIVIISISHFKQLHTPTNWLLHSMAVVDFLLGCLVMPYSMVRTVEHCWYFGELFCKLHTSTDIMLSSASILHLAFISIDRYYAVCDPLRYKAKINLAAIFVMILISWSLPAVFAFGMIFLELNLEGVEELYHNQVFCLRGCFPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRANLQVGLEGESRAPQSKETKAAKTLGIMVGVFLLCWCPFFFCMVLDPFLGYVIPPTLNDTLNWFGYLNSAFNPMVYAFFYPWFRRALKMVLFGKIFQKDSSRSKLFL
UniProt	Q923Y9
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3833
IUPHAR	364
DrugBank	N/A

Ligand

Name	(+)-Paredrine
Molecular formula	C9H13NO
IUPAC name	4-[(2S)-2-aminopropyl]phenol
Molecular weight	151.209
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	1.4
Synonyms	D-4-Hydroxyamphetamine UNII-7UDF5TX27X (+)-p-Hydroxyamphetamine DTXSID10349250 ZINC1690604 (S)-4-(2-AMINOPROPYL)PHENOL AKOS027332706 CHEMBL1927024 phenol, 4-[(2S)-2-aminopropyl]- 4-Hydroxy-dextroamphetamine d-p-hydroxy-alpha-methylphenethylamine UNII-FQR280JW2N component GIKNHHRFLCDOEU-SSDOTTSWSA-N 7UDF5TX27X p-Hydroxyphenylisopropylamine (S)-P-Hydroxyamphetamine BDBM50359501 d-1-p-hydroxyphenyl-2-propylamine SCHEMBL256809 (+)-4-Hydroxyamphetamine 4-[(2S)-2-aminopropyl]phenol d-p-Hydroxyamphetamine UNII-FQR280JW2N component GIKNHHRFLCDOEU-ZETCQYMHSA-N (+)-Paredrinex AC1LD8EI Phenol, 4-((2S)-2-aminopropyl)- 1693-66-9 [ Show all ]
Inchi Key	GIKNHHRFLCDOEU-ZETCQYMHSA-N
Inchi ID	InChI=1S/C9H13NO/c1-7(10)6-8-2-4-9(11)5-3-8/h2-5,7,11H,6,10H2,1H3/t7-/m0/s1
PubChem CID	644000
ChEMBL	CHEMBL1927024
IUPHAR	N/A
BindingDB	50359501
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	50.0 nM	PMID22037049	BindingDB
EC50	190.0 nM	PMID22037049	BindingDB,ChEMBL

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