●I-TASSER ●D-I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●D-QUARK ●DRfold ●DRfold2 ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●ATGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●DMFold ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred ●TCRfinder

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●TM-search ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●DeepMSA2 ●rMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●HPmod ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

TACOS (Template-based Assembly of Complex Structures) is designed to model the structures of protein-protein complexes based on a hierarchical approach of threading refinement simulations. Starting from a pair of sequences, protein complex templates are first identified from the PDB by multi-chain threading algorithms COTH and SPRING. The fragments excised from the threading template alignments are then used to reassemble the complex structure by replica-exchange Monte Carlo simulations based on a composite force field consisting of knowledge-based interface interaction terms and threading template restraints. Final models are selected based on structure clustering by SPICKER and refined into full-atomic models by ModRefiner (More about the server ... ).

The output of the TACOS server include (An example of the TACOS output):

• Top 10 query-template alignments from COTH and SPRING threading.
• Up to 5 full-length atomic models generated by TACOS.

TACOS On-line

Input your first sequence below ([30,1000] residues in FASTA format). Example input:


Or upload the sequence from your local computer:

Input your second sequence below ([30,1000] residues in FASTA format). Example input:


Or upload the sequence from your local computer:

Email: (mandatory, where results will be sent to)

ID: (optional, your given name of the protein)

• Download the TACOS standalone package
• The TACOS template library

• Zi Liu, Brandon Govindarajoo, Srayanta Mukherjee, Chengxin Zhang, Aysam Guerler, Jeffrey Brender, Zhiping Weng, Dong-Jun Yu, Yang Zhang. Full-length protein quaternary structure prediction by multi-chain threading fragment reassembly. submitted, 2022.