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GPCR

NameMetabotropic glutamate receptor 2
SpeciesRattus norvegicus (Rat)
GeneGrm2
Synonymglutamate receptor
GPRC1B
metabotropic glutamate receptor 2
mGlu2 receptor
mGluR2
DiseaseN/A for non-human GPCRs
Length872
Amino acid sequenceMESLLGFLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEECGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHSDAPTAVTGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAATQRLNASFTWVASDGWGALESVVAGSERAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEERFHCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTHLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTDDEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSFIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFVFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVAAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAPRASANLGQGSGSQFVPTVCNGREVVDSTTSSL
UniProtP31421
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2851
IUPHAR290
DrugBankN/A

Ligand

NameVU 0361737
Molecular formulaC13H11ClN2O2
IUPAC nameN-(4-chloro-3-methoxyphenyl)pyridine-2-carboxamide
Molecular weight262.693
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP2.6
SynonymsJ-003384
N-(4-chloro-3-methoxyphenyl)picolinamide
SC-95549
VU0361737-1
BCP06488
[ Show all ]
Inchi KeyARYUXFNGXHNNDM-UHFFFAOYSA-N
Inchi IDInChI=1S/C13H11ClN2O2/c1-18-12-8-9(5-6-10(12)14)16-13(17)11-4-2-3-7-15-11/h2-8H,1H3,(H,16,17)
PubChem CID44191096
ChEMBLCHEMBL562551
IUPHAR3956
BindingDB50293721
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC501039.7 nMPubChem BioAssay data setChEMBL

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