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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Trace amine-associated receptor 1
Species	Mus musculus (Mouse)
Gene	Taar1
Synonym	TA1 receptor TaR-1 TAR1 trace amine receptor 1 TRAR1
Disease	N/A for non-human GPCRs
Length	332
Amino acid sequence	MHLCHAITNISHRNSDWSREVQASLYSLMSLIILATLVGNLIVIISISHFKQLHTPTNWLLHSMAIVDFLLGCLIMPCSMVRTVERCWYFGEILCKVHTSTDIMLSSASIFHLAFISIDRYCAVCDPLRYKAKINISTILVMILVSWSLPAVYAFGMIFLELNLKGVEELYRSQVSDLGGCSPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRTNVQVGLEGKSQAPQSKETKAAKTLGIMVGVFLVCWCPFFLCTVLDPFLGYVIPPSLNDALYWFGYLNSALNPMVYAFFYPWFRRALKMVLLGKIFQKDSSRSKLFL
UniProt	Q923Y8
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4908
IUPHAR	364
DrugBank	N/A

Ligand

Name	L-Amphetamine
Molecular formula	C9H13N
IUPAC name	(2R)-1-phenylpropan-2-amine
Molecular weight	135.21
Hydrogen bond acceptor	1
Hydrogen bond donor	1
XlogP	1.8
Synonyms	KWTSXDURSIMDCE-MRVPVSSYSA-N Levamfetamina Levamphetaminum R(-)-Amphetamine (levo-Amphetamine), 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material (-)-(R)-Amphetamine Hydrochloride (R)-a-Methyl-benzeneethanamine (R)-Amphetamine; Levamphetamine Benzeneethanamine, alpha-methyl-, (R)- CHEMBL19393 l-a-Methylphenethylamine Levamfetamine hydrochloride Levoamphetamine SCHEMBL2636 (-)-Amphetamine Hydrochloride (R)-alpha-Methyl-benzeneethanamine (\|AR)-\|A-Methyl-benzeneethanamine Hydrochloride ACN-053516 EINECS 205-850-8 l-Amphetamine Hydrochloride Levamfetaminum [INN-Latin] PDSP2_001494 ZINC6036847 (2R)-1-phenylpropan-2-amine (R)-Amphetamine AKOS022172419 l-(-)-Amphetamine Hydrochloride Levamfetamina [DCIT] Levanfetamina R(-)amphetamine (-)-alpha-Methylphenethylamine (R)-a-methylbenzeneethanamine (R)-Phenaminum AB07478 CHEBI:42724 D07BAH l-alpha-Methylphenethylamine Levamfetamine [INN:BAN] LS-103616 UNII-CK833KGX7E component KWTSXDURSIMDCE-MRVPVSSYSA-N (-)-Phenaminum Hydrochloride (R)-alpha-Methylbenzeneethanamine 156-34-3 ACT09042 GTPL2146 l-\|A-Methylphenethylamine Hydrochloride Levamphetamine Phenethylamine, alpha-methyl-, (-)- (R)-1-Phenylpropan-2-amine (R)-Amphetamine Hydrochloride 41820-21-7 BDBM50022721 l-(R)-Amphetamine Levamfetamine Levanfetamina [INN-Spanish] R87US8P740 (-)-Amphetamine (R)-a-methylphenethylamine (R)-phenylisopropylamine AC1L1OMX DTXSID20166016 Levamfetaminum PDSP1_001510 UNII-R87US8P740 (-)-Phenylisopropylamine (R)-alpha-Methylphenethylamine 190011-EP2280010A2 AJ-55558 [ Show all ]
Inchi Key	KWTSXDURSIMDCE-MRVPVSSYSA-N
Inchi ID	InChI=1S/C9H13N/c1-8(10)7-9-5-3-2-4-6-9/h2-6,8H,7,10H2,1H3/t8-/m1/s1
PubChem CID	32893
ChEMBL	CHEMBL19393
IUPHAR	2146
BindingDB	50022721
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	63.0957 - 5011.87 nM	PMID17218486, PMID17212650	IUPHAR
EC50	65.0 nM	PMID22037049	BindingDB,ChEMBL
EC50	785.5 nM	PMID24354319	ChEMBL
EC50	4960.0 nM	PMID22037049	BindingDB,ChEMBL
Emax	93.58 %	PMID24354319	ChEMBL

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