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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	P2Y purinoceptor 6
Species	Rattus norvegicus (Rat)
Gene	P2ry6
Synonym	P2Y ATP receptor 6 P2Y purinoceptor 6 P2Y6 P2Y6 receptor pyrimidinergic receptor P2Y uridine nucleotide receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	328
Amino acid sequence	MERDNGTIQAPGLPPTTCVYREDFKRLLLPPVYSVVLVVGLPLNVCVIAQICASRRTLTRSAVYTLNLALADLLYACSLPLLIYNYARGDHWPFGDLACRLVRFLFYANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWVVCGVVWLVVTAQCLPTAVFAATGIQRNRTVCYDLSPPILSTRYLPYGMALTVIGFLLPFTALLACYCRMARRLCRQDGPAGPVAQERRSKAARMAVVVAAVFVISFLPFHITKTAYLAVRSTPGVSCPVLETFAAAYKGTRPFASANSVLDPILFYFTQQKFRRQPHDLLQKLTAKWQRQRV
UniProt	Q63371
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3543
IUPHAR	326
DrugBank	N/A

Ligand

Name	CHEMBL214698
Molecular formula	C9H13BrN2O12P2
IUPAC name	[(2R,3S,4R,5R)-5-(5-bromo-2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphono hydrogen phosphate
Molecular weight	483.057
Hydrogen bond acceptor	12
Hydrogen bond donor	6
XlogP	-4.1
Synonyms	((2R,3S,4R,5R)-5-(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl trihydrogen diphosphate 5-Br-UDP BDBM50199173 SCHEMBL3026247 5-bromo-1-beta-D-ribofuranosyl(3H)pyrimidine-2,4-dione 5''-diphosphate
Inchi Key	LEODOYNQKMXKRC-UAKXSSHOSA-N
Inchi ID	InChI=1S/C9H13BrN2O12P2/c10-3-1-12(9(16)11-7(3)15)8-6(14)5(13)4(23-8)2-22-26(20,21)24-25(17,18)19/h1,4-6,8,13-14H,2H2,(H,20,21)(H,11,15,16)(H2,17,18,19)/t4-,5-,6-,8-/m1/s1
PubChem CID	23379800
ChEMBL	CHEMBL214698
IUPHAR	N/A
BindingDB	50199173
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor.

Experimental Data

Parameter	Value	Reference	Database source
EC50	130.0 nM	PMID17125260, PMID20095577	BindingDB,ChEMBL

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