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Name | Corticotropin-releasing factor receptor 1 |
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Species | Rattus norvegicus (Rat) |
Gene | Crhr1 |
Synonym | CRH-R1 CRH-R-1 CRFR1 CRFR-1 CRF1 receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 415 |
Amino acid sequence | MGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEVHQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPFPIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV |
UniProt | P35353 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4649 |
IUPHAR | 212 |
DrugBank | N/A |
Name | CHEMBL563618 |
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Molecular formula | C18H21Cl2N3O2 |
IUPAC name | 1-[(1R)-1-cyclopropylethyl]-3-(2,6-dichloro-N-ethyl-4-methoxyanilino)pyrazin-2-one |
Molecular weight | 382.285 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 0 |
XlogP | 3.8 |
Synonyms | BDBM50293980 (R)-5-Chloro-1-(1-cyclopropylethyl)-3-[(2,6-dichloro-4-methoxyphenyl)(ethyl)amino]pyrazin-2(1H)-one |
Inchi Key | ACZGTUUOYXZHMJ-LLVKDONJSA-N |
Inchi ID | InChI=1S/C18H21Cl2N3O2/c1-4-22(16-14(19)9-13(25-3)10-15(16)20)17-18(24)23(8-7-21-17)11(2)12-5-6-12/h7-12H,4-6H2,1-3H3/t11-/m1/s1 |
PubChem CID | 45273018 |
ChEMBL | CHEMBL563618 |
IUPHAR | N/A |
BindingDB | 50293980 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
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IC50 | 34.0 nM | PMID19552437 | BindingDB,ChEMBL |
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