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| Name | Corticotropin-releasing factor receptor 1 |
|---|---|
| Species | Rattus norvegicus (Rat) |
| Gene | Crhr1 |
| Synonym | CRH-R1 CRH-R-1 CRFR1 CRFR-1 CRF1 receptor [ Show all ] |
| Disease | N/A for non-human GPCRs |
| Length | 415 |
| Amino acid sequence | MGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEVHQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPFPIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV |
| UniProt | P35353 |
| Protein Data Bank | N/A |
| GPCR-HGmod model | N/A |
| 3D structure model | No available structures or models |
| BioLiP | N/A |
| Therapeutic Target Database | N/A |
| ChEMBL | CHEMBL4649 |
| IUPHAR | 212 |
| DrugBank | N/A |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 508 |  CHEMBL455588 | C20H27N5O3 | 385.468 | 7 / 0 | 2.7 | Yes |
| 1729 |  CHEMBL519340 | C20H26FN5O | 371.46 | 6 / 1 | 5.1 | No |
| 2049 |  CHEMBL563618 | C18H21Cl2N3O2 | 382.285 | 3 / 0 | 3.8 | Yes |
| 3005 |  CHEMBL168764 | C13H14IN3 | 339.18 | 3 / 0 | 3.7 | Yes |
| 4495 |  Pyridopyrazine, 3b | C23H34N4O3 | 414.55 | 7 / 1 | 4.2 | Yes |
| 5313 |  CHEMBL2058592 | C22H22ClF2N3O2 | 433.884 | 6 / 0 | 5.4 | No |
| 521621 |  CHEMBL3798004 | C23H23ClF3N5O3 | 509.914 | 9 / 1 | 4.3 | No |
| 6023 |  CHEMBL355289 | C17H22BrN3 | 348.288 | 3 / 0 | 5.2 | No |
| 6509 |  Pyridopyrazinone, 5a | C23H30N4O2 | 394.519 | 5 / 1 | 4.0 | Yes |
| 6544 |  CHEMBL541756 | C19H24ClN3O | 345.871 | 2 / 1 | 4.5 | Yes |
| 7194 |  CHEMBL2165199 | C17H19Cl3FN3O4 | 454.704 | 6 / 1 | 3.0 | Yes |
| 7437 |  Pyridopyrazine, 1b | C22H32N4O | 368.525 | 5 / 1 | 5.1 | No |
| 8542 |  CHEMBL271373 | C23H33NO3 | 371.521 | 4 / 1 | 5.7 | No |
| 8669 |  CHEMBL1086508 | C16H15Cl2F3N4O | 407.218 | 5 / 1 | 4.2 | Yes |
| 9350 |  CHEMBL474901 | C22H31N5O2 | 397.523 | 6 / 0 | 4.9 | Yes |
| 9361 |  CHEMBL364883 | C23H31ClN4O | 414.978 | 4 / 1 | 5.7 | No |
| 9714 |  195055-03-9 | C22H32N6 | 380.54 | 5 / 0 | 4.7 | Yes |
| 10332 |  CHEMBL1086510 | C17H17Cl2F3N4O2 | 437.244 | 6 / 1 | 3.7 | Yes |
| 10517 |  CHEMBL584343 | C18H23ClN4O2 | 362.858 | 4 / 1 | 3.4 | Yes |
| 14310 |  CHEMBL2349560 | C18H19BrCl2FN3O3 | 495.17 | 5 / 1 | 4.0 | Yes |
| 14544 |  CHEMBL426607 | C21H24Cl2N4O | 419.35 | 3 / 0 | 5.2 | No |
| 14953 |  CHEMBL427971 | C158H263N47O42 | 3493.13 | 48 / 47 | -9.6 | No |
| 15165 |  CHEMBL560823 | C18H22ClN3O2 | 347.843 | 3 / 2 | 2.9 | Yes |
| 15613 |  CHEMBL2058594 | C22H24FN3O2 | 381.451 | 5 / 0 | 3.9 | Yes |
| 17480 |  CHEMBL2165195 | C19H23ClFN3O3 | 395.859 | 5 / 1 | 3.5 | Yes |
| 19673 |  CHEMBL355202 | C25H25N3O | 383.495 | 3 / 1 | 4.5 | Yes |
| 20263 |  CHEMBL271546 | C20H26ClNO2 | 347.883 | 3 / 0 | 6.7 | No |
| 21255 |  CHEMBL2058606 | C21H21ClF2N4O2 | 434.872 | 7 / 0 | 4.8 | Yes |
| 22740 |  CHEMBL201982 | C26H29N3O3S | 463.596 | 6 / 1 | 5.9 | No |
| 22761 |  CHEMBL204690 | C29H30N2O4S | 502.629 | 6 / 1 | 7.0 | No |
| 22933 |  astressin B | C183H305N47O55 | 4043.73 | 61 / 54 | -14.5 | No |
| 23480 |  CHEMBL565169 | C18H22ClN3O3 | 363.842 | 4 / 2 | 2.5 | Yes |
| 522313 |  CHEMBL3797955 | C23H23ClN6O3 | 466.926 | 7 / 1 | 3.1 | Yes |
| 24720 |  CHEMBL1828889 | C20H26ClN5O | 387.912 | 5 / 1 | 5.4 | No |
| 24934 |  CHEMBL166102 | C15H18BrN3 | 320.234 | 3 / 0 | 4.5 | Yes |
| 25346 |  CHEMBL563819 | C15H13Cl3N4O2 | 387.645 | 4 / 1 | 2.9 | Yes |
| 26857 |  CHEMBL1762823 | C19H25FN6O2 | 388.447 | 8 / 0 | 2.8 | Yes |
| 29975 |  CHEMBL560033 | C17H18Cl3N3O2 | 402.7 | 3 / 1 | 4.6 | Yes |
| 31121 |  CHEMBL165818 | C18H16BrN3 | 354.251 | 2 / 0 | 4.8 | Yes |
| 33377 |  CHEMBL164206 | C25H34N4 | 390.575 | 3 / 0 | 6.6 | No |
| 33594 |  CHEMBL186203 | C20H24Cl2N4O | 407.339 | 4 / 1 | 5.2 | No |
| 522628 |  SCHEMBL1786667 | C22H30ClN5O4 | 463.963 | 6 / 2 | 3.5 | Yes |
| 38237 |  CHEMBL574852 | C18H21ClF2N4O3 | 414.838 | 7 / 1 | 3.3 | Yes |
| 38238 |  CHEMBL572589 | C18H21ClF2N4O3 | 414.838 | 7 / 1 | 3.3 | Yes |
| 39309 |  CHEMBL360532 | C23H25ClN4O2 | 424.929 | 4 / 0 | 5.1 | No |
| 39609 |  CHEMBL441750 | C149H253N49O43S2 | 3483.08 | 52 / 49 | -14.2 | No |
| 39610 |  CHEMBL408724 | C149H253N49O43S2 | 3483.08 | 52 / 49 | -14.2 | No |
| 39611 |  CHEMBL438756 | C149H253N49O43S2 | 3483.08 | 52 / 49 | -14.2 | No |
| 39612 |  CHEMBL442300 | C149H253N49O43S2 | 3483.08 | 52 / 49 | -14.2 | No |
| 39643 |  CHEMBL1085734 | C16H18Cl2N4O3S | 417.305 | 4 / 1 | 2.6 | Yes |
| 42390 |  CHEMBL381824 | C29H30N2O4S | 502.629 | 6 / 1 | 7.0 | No |
| 42738 |  CHEMBL2058597 | C22H21ClN4O | 392.887 | 4 / 0 | 4.2 | Yes |
| 43849 |  CHEMBL559633 | C20H28ClN3O | 361.914 | 2 / 1 | 5.3 | No |
| 44368 |  CHEMBL1082705 | C18H21N5O | 323.4 | 3 / 1 | 2.5 | Yes |
| 44504 |  CHEMBL453001 | C17H22N6O | 326.404 | 6 / 0 | 3.0 | Yes |
| 44940 |  CHEMBL573284 | C18H21N5O2 | 339.399 | 5 / 1 | 1.9 | Yes |
| 47923 |  Pteridine, 5d | C22H31N5O | 381.524 | 6 / 1 | 4.5 | Yes |
| 47963 |  CHEMBL272804 | C23H33NO2 | 355.522 | 3 / 0 | 7.2 | No |
| 48533 |  CHEMBL115836 | C30H47Cl3N4Sn | 688.794 | 4 / 1 | N/A | No |
| 51723 |  CHEMBL348967 | C24H33FN4 | 396.554 | 4 / 0 | 6.4 | No |
| 523054 |  CHEMBL3798497 | C25H29ClN6O5 | 528.994 | 8 / 2 | 3.4 | No |
| 52234 |  CHEMBL408028 | C21H29NO3 | 343.467 | 4 / 0 | 5.4 | No |
| 52265 |  CHEMBL1085930 | C20H26ClN5O | 387.912 | 4 / 1 | 3.5 | Yes |
| 53014 |  CHEMBL437101 | C159H263N47O43 | 3521.14 | 49 / 47 | -9.7 | No |
| 53015 |  CHEMBL436900 | C159H263N47O43 | 3521.14 | 49 / 47 | -9.7 | No |
| 54426 |  CHEMBL182169 | C20H24Cl2N4O | 407.339 | 3 / 0 | 5.4 | No |
| 54709 |  CHEMBL259467 | C20H27NO2 | 313.441 | 3 / 0 | 5.9 | No |
| 56222 |  CHEMBL561230 | C17H16Cl2N4O | 363.242 | 3 / 1 | 3.6 | Yes |
| 56386 |  CHEMBL2165202 | C18H24BrN3O4 | 426.311 | 5 / 1 | 2.2 | Yes |
| 56502 |  CHEMBL2058598 | C22H24ClN3O2 | 397.903 | 4 / 0 | 4.4 | Yes |
| 58156 |  CHEMBL2165201 | C18H23BrFN3O4 | 444.301 | 6 / 1 | 2.7 | Yes |
| 59322 |  CHEMBL186252 | C23H31BrN4O | 459.432 | 4 / 1 | 5.8 | No |
| 60460 |  CHEMBL564968 | C16H17Cl2N3O | 338.232 | 2 / 1 | 4.0 | Yes |
| 60821 |  CHEMBL483349 | C18H24N6O | 340.431 | 6 / 0 | 3.5 | Yes |
| 61689 |  CHEMBL273033 | C23H33NO3 | 371.521 | 4 / 0 | 6.8 | No |
| 62016 |  UNII-7FC996ZZL5 | C21H29N5O3 | 399.495 | 7 / 0 | 3.0 | Yes |
| 62884 |  CHEMBL559437 | C19H24ClN3O3 | 377.869 | 4 / 1 | 3.0 | Yes |
| 62886 |  CHEMBL560036 | C19H24ClN3O3 | 377.869 | 4 / 1 | 3.0 | Yes |
| 63688 |  CHEMBL2058604 | C19H18Cl2N4O | 389.28 | 4 / 0 | 4.1 | Yes |
| 63738 |  CHEMBL10504 | C20H27BrN6O2 | 463.38 | 7 / 0 | 3.8 | Yes |
| 64195 |  CHEMBL2372247 | C162H270N50O43 | 3606.25 | 50 / 49 | -10.9 | No |
| 64911 |  CHEMBL1084026 | C18H24N4O2 | 328.416 | 3 / 1 | 2.8 | Yes |
| 65965 |  CHEMBL1083292 | C18H22F3N5O2 | 397.402 | 7 / 1 | 3.1 | Yes |
| 66334 |  CHEMBL353075 | C14H16BrN3 | 306.207 | 3 / 0 | 4.1 | Yes |
| 66343 |  CHEMBL552237 | C19H26ClN3O | 347.887 | 2 / 1 | 4.8 | Yes |
| 66603 |  CHEMBL432496 | C20H27BrN4O | 419.367 | 5 / 0 | 4.9 | Yes |
| 67544 |  CHEMBL2058589 | C23H26ClN3O2 | 411.93 | 4 / 0 | 4.8 | Yes |
| 68460 |  CHEMBL184938 | C21H28Cl2N4O | 423.382 | 3 / 0 | 6.3 | No |
| 72013 |  CHEMBL550216 | C17H15Cl3F3N3O2 | 456.671 | 6 / 1 | 4.5 | Yes |
| 72351 |  CHEMBL560098 | C17H22ClN3O2 | 335.832 | 3 / 1 | 3.1 | Yes |
| 72644 |  CHEMBL2165197 | C16H18Cl3N3O4 | 422.687 | 5 / 1 | 2.7 | Yes |
| 72672 |  CHEMBL355135 | C18H16BrN3O | 370.25 | 2 / 1 | 3.5 | Yes |
| 72998 |  CHEMBL572588 | C16H19ClF2N4O3 | 388.8 | 7 / 1 | 2.9 | Yes |
| 73138 |  CHEMBL363654 | C20H24ClFN4O2 | 406.886 | 6 / 1 | 4.2 | Yes |
| 73211 |  CHEMBL49217 | C19H24N4 | 308.429 | 3 / 1 | 4.8 | Yes |
| 77210 |  CHEMBL182497 | C23H32Cl2N4O | 451.436 | 3 / 0 | 7.2 | No |
| 77428 |  CHEMBL561225 | C18H17F3N4O2 | 378.355 | 7 / 1 | 2.4 | Yes |
| 77463 |  CHEMBL1083590 | C17H20F3N5O2 | 383.375 | 7 / 1 | 2.8 | Yes |
| 77865 |  CHEMBL519999 | C22H31N5O2 | 397.523 | 6 / 0 | 5.1 | No |
| 78595 |  CP-154526 | C23H32N4 | 364.537 | 3 / 0 | 6.2 | No |
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