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Name | Corticotropin-releasing factor receptor 1 |
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Species | Rattus norvegicus (Rat) |
Gene | Crhr1 |
Synonym | CRH-R1 CRH-R-1 CRFR1 CRFR-1 CRF1 receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 415 |
Amino acid sequence | MGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEVHQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPFPIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV |
UniProt | P35353 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4649 |
IUPHAR | 212 |
DrugBank | N/A |
Name | CHEMBL565169 |
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Molecular formula | C18H22ClN3O3 |
IUPAC name | 5-chloro-1-[(1R)-1-cyclopropyl-2-hydroxyethyl]-3-(4-methoxy-2,5-dimethylanilino)pyrazin-2-one |
Molecular weight | 363.842 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 2 |
XlogP | 2.5 |
Synonyms | (R)-5-Chloro-1-(1-cyclopropyl-2-hydroxyethyl)-3-(4-methoxy-2,5-dimethylphenylamino)pyrazin-2(1H)-one BDBM50293955 |
Inchi Key | BGWHXWXUGVBBRJ-AWEZNQCLSA-N |
Inchi ID | InChI=1S/C18H22ClN3O3/c1-10-7-15(25-3)11(2)6-13(10)20-17-18(24)22(8-16(19)21-17)14(9-23)12-4-5-12/h6-8,12,14,23H,4-5,9H2,1-3H3,(H,20,21)/t14-/m0/s1 |
PubChem CID | 44190147 |
ChEMBL | CHEMBL565169 |
IUPHAR | N/A |
BindingDB | 50293955 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
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IC50 | 10.0 nM | PMID19552437 | BindingDB,ChEMBL |
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