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Name | Corticotropin-releasing factor receptor 1 |
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Species | Rattus norvegicus (Rat) |
Gene | Crhr1 |
Synonym | CRH-R1 CRH-R-1 CRFR1 CRFR-1 CRF1 receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 415 |
Amino acid sequence | MGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEVHQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPFPIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV |
UniProt | P35353 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4649 |
IUPHAR | 212 |
DrugBank | N/A |
Name | CHEMBL563819 |
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Molecular formula | C15H13Cl3N4O2 |
IUPAC name | 3,5-dichloro-4-[[6-chloro-4-[(2R)-1-methoxypropan-2-yl]-3-oxopyrazin-2-yl]amino]benzonitrile |
Molecular weight | 387.645 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 1 |
XlogP | 2.9 |
Synonyms | BDBM50293921 (R)-3,5-Dichloro-4-[6-chloro-4-(2-methoxy-1-methylethyl)-3-oxo-3,4-dihydropyrazin-2-ylamino]benzonitrile |
Inchi Key | BJPKLUWKFANWNW-MRVPVSSYSA-N |
Inchi ID | InChI=1S/C15H13Cl3N4O2/c1-8(7-24-2)22-6-12(18)20-14(15(22)23)21-13-10(16)3-9(5-19)4-11(13)17/h3-4,6,8H,7H2,1-2H3,(H,20,21)/t8-/m1/s1 |
PubChem CID | 44190824 |
ChEMBL | CHEMBL563819 |
IUPHAR | N/A |
BindingDB | 50293921 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
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IC50 | 18.0 nM | PMID19552436 | BindingDB,ChEMBL |
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