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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Hydroxycarboxylic acid receptor 3
Species	Homo sapiens (Human)
Gene	HCAR3
Synonym	G-protein coupled receptor 109B Nicotinic acid receptor 2 Nic2 NIACR2 Niacin receptor 2 Low affinity nicotinic acid receptor G protein-coupled receptor 109B G-protein coupled receptor HM74B G-protein coupled receptor HM74 HCA3 receptor [ Show all ]
Disease	N/A
Length	387
Amino acid sequence	MNRHHLQDHFLEIDKKNCCVFRDDFIAKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFVMDYYVRRSDWKFGDIPCRLVLFMFAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNWTAAIISCLLWGITVGLTVHLLKKKLLIQNGTANVCISFSICHTFRWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIHIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKITGEPDNNRSTSVELTGDPNKTRGAPEALIANSGEPWSPSYLGPTSNNHSKKGHCHQEPASLEKQLGCCIE
UniProt	P49019
Protein Data Bank	N/A
GPCR-HGmod model	P49019
3D structure model	This predicted structure model is from GPCR-EXP P49019.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4421
IUPHAR	313
DrugBank	BE0000836

Ligand

Name	6-(cyclopropylamino)pyridine-3-carboxylic acid
Molecular formula	C9H10N2O2
IUPAC name	6-(cyclopropylamino)pyridine-3-carboxylic acid
Molecular weight	178.191
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	1.3
Synonyms	CHEMBL235615 ZINC19844609 AB00996116-01 F6146-0140 3-Pyridinecarboxylic acid, 6-(cyclopropylamino)- BJWSFKCKOOIPSA-UHFFFAOYSA-N NE60043 6-cyclopropylamino-nicotinic acid CTK7I8212 AC1Q73YP MCULE-6083683861 6-(cyclopropylamino)nicotinic acid SCHEMBL1542481 960060-88-2 EN300-50671 AKOS000214499 MolPort-004-366-882 [ Show all ]
Inchi Key	BJWSFKCKOOIPSA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C9H10N2O2/c12-9(13)6-1-4-8(10-5-6)11-7-2-3-7/h1,4-5,7H,2-3H2,(H,10,11)(H,12,13)
PubChem CID	28400038
ChEMBL	CHEMBL235615
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	323.59 nM	PMID17931863	ChEMBL

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