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Name | Hydroxycarboxylic acid receptor 3 |
---|---|
Species | Homo sapiens (Human) |
Gene | HCAR3 |
Synonym | G-protein coupled receptor 109B Nicotinic acid receptor 2 Nic2 NIACR2 Niacin receptor 2 [ Show all ] |
Disease | N/A |
Length | 387 |
Amino acid sequence | MNRHHLQDHFLEIDKKNCCVFRDDFIAKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFVMDYYVRRSDWKFGDIPCRLVLFMFAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNWTAAIISCLLWGITVGLTVHLLKKKLLIQNGTANVCISFSICHTFRWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIHIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKITGEPDNNRSTSVELTGDPNKTRGAPEALIANSGEPWSPSYLGPTSNNHSKKGHCHQEPASLEKQLGCCIE |
UniProt | P49019 |
Protein Data Bank | N/A |
GPCR-HGmod model | P49019 |
3D structure model | This predicted structure model is from GPCR-EXP P49019. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4421 |
IUPHAR | 313 |
DrugBank | BE0000836 |
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GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
---|---|---|---|---|---|---|
27 | 6-n-butylamino-3-pyridine carboxylic acid | C10H14N2O2 | 194.234 | 4 / 2 | 1.9 | Yes |
1642 | 4-(dipropylamino)-3-nitrobenzoic acid | C13H18N2O4 | 266.297 | 5 / 1 | 3.2 | Yes |
3249 | CHEMBL238385 | C10H14N2O3 | 210.233 | 5 / 2 | 1.0 | Yes |
3760 | CHEMBL3299115 | C18H19NO5 | 329.352 | 5 / 2 | 2.8 | Yes |
5529 | CHEMBL559204 | C14H13N3O2S2 | 319.397 | 6 / 2 | 2.9 | Yes |
7159 | CHEMBL1224147 | C16H14FN3O2 | 299.305 | 5 / 1 | 1.9 | Yes |
7288 | CHEMBL238387 | C10H14N2O2 | 194.234 | 4 / 1 | 1.7 | Yes |
8634 | CHEMBL223700 | C12H8F2O4 | 254.189 | 6 / 1 | 1.9 | Yes |
12519 | SCH-900271 | C14H16N2O4 | 276.292 | 4 / 2 | 1.6 | Yes |
17160 | 1-cyclobutyl-1H-benzotriazole-5-carboxylic acid | C11H11N3O2 | 217.228 | 4 / 1 | 1.8 | Yes |
18409 | CHEMBL385103 | C12H8F2O4 | 254.189 | 6 / 1 | 1.9 | Yes |
25523 | 6-(cyclopropylamino)pyridine-3-carboxylic acid | C9H10N2O2 | 178.191 | 4 / 2 | 1.3 | Yes |
31430 | CHEMBL1672639 | C15H16F2N2O3 | 310.301 | 6 / 1 | 2.7 | Yes |
32001 | CHEMBL202206 | C11H13N3O2 | 219.244 | 4 / 1 | 1.8 | Yes |
32714 | CHEMBL238375 | C11H14N2O4 | 238.243 | 5 / 1 | 2.3 | Yes |
35419 | CHEMBL560254 | C10H17N3O2 | 211.265 | 4 / 2 | 2.3 | Yes |
39180 | CHEMBL561720 | C12H17N3O2 | 235.287 | 4 / 2 | 2.0 | Yes |
42374 | 5-isopropyl-1H-pyrazole-3-carboxylic acid | C7H10N2O2 | 154.169 | 3 / 2 | 1.2 | Yes |
45086 | 4-(allylamino)-3-nitrobenzoic acid | C10H10N2O4 | 222.2 | 5 / 2 | 2.5 | Yes |
46066 | 4-(cyclopentylamino)-3-nitrobenzoic acid | C12H14N2O4 | 250.254 | 5 / 2 | 3.1 | Yes |
46197 | CHEMBL202657 | C14H9F2N3O2 | 289.242 | 6 / 1 | 2.4 | Yes |
553463 | D-phenylalanine | C9H11NO2 | 165.192 | 3 / 2 | -1.5 | Yes |
48984 | CHEMBL562675 | C14H13N3O2S2 | 319.397 | 6 / 2 | 3.0 | Yes |
53192 | CHEMBL2036951 | C11H10F2N2O4 | 272.208 | 6 / 2 | 0.6 | Yes |
56810 | CHEMBL374111 | C12H9ClO4 | 252.65 | 4 / 1 | 2.3 | Yes |
58466 | ACIFRAN | C12H10O4 | 218.208 | 4 / 1 | 1.7 | Yes |
58660 | CHEMBL1671877 | C14H14F2N2O3 | 296.274 | 6 / 1 | 2.3 | Yes |
60161 | CHEMBL561920 | C18H17N3O2 | 307.353 | 4 / 2 | 3.5 | Yes |
61737 | ACIPIMOX | C6H6N2O3 | 154.125 | 4 / 1 | -1.0 | Yes |
66128 | 4-(sec-butylamino)-3-nitrobenzoic acid | C11H14N2O4 | 238.243 | 5 / 2 | 3.1 | Yes |
71891 | 1-Benzyl-1,2,3-benzotriazole-5-carboxylic acid | C14H11N3O2 | 253.261 | 4 / 1 | 2.2 | Yes |
76183 | CHEMBL397055 | C6H7FN6 | 182.162 | 5 / 2 | 0.4 | Yes |
84672 | CHEMBL393064 | C7H10N6 | 178.199 | 4 / 2 | 0.7 | Yes |
91851 | CHEMBL550153 | C14H13N3O3S | 303.336 | 6 / 2 | 2.3 | Yes |
97409 | CHEMBL220001 | C13H9F3O4 | 286.206 | 7 / 1 | 2.6 | Yes |
99321 | 1-Cyclohexyl-1H-benzotriazole-5-carboxylic acid | C13H15N3O2 | 245.282 | 4 / 1 | 2.6 | Yes |
101871 | CHEMBL383367 | C20H15N3O2 | 329.359 | 4 / 1 | 3.9 | Yes |
102125 | CHEMBL562933 | C14H25N3O2 | 267.373 | 4 / 2 | 3.9 | Yes |
103782 | CHEMBL223140 | C10H8O4S | 224.23 | 5 / 1 | 1.4 | Yes |
112443 | CHEMBL201048 | C12H15N3O2 | 233.271 | 4 / 1 | 2.7 | Yes |
116666 | CHEMBL2036813 | C11H12N2O4 | 236.227 | 4 / 2 | 0.7 | Yes |
123535 | CHEMBL439028 | C14H10N2O5 | 286.243 | 5 / 2 | 2.3 | Yes |
124489 | CHEMBL219950 | C14H14O4 | 246.262 | 4 / 1 | 2.5 | Yes |
125920 | CHEMBL373880 | C10H8O5 | 208.169 | 5 / 1 | 0.8 | Yes |
127690 | 6-(dipropylamino)nicotinic acid | C12H18N2O2 | 222.288 | 4 / 1 | 2.6 | Yes |
132887 | CHEMBL3299016 | C19H17ClN2O3 | 356.806 | 4 / 2 | 4.3 | Yes |
132941 | CHEMBL223623 | C11H10O4S | 238.257 | 5 / 1 | 1.8 | Yes |
135653 | 4-(cyclopropylamino)-3-nitrobenzoic acid | C10H10N2O4 | 222.2 | 5 / 2 | 2.4 | Yes |
138447 | CHEMBL3299014 | C22H24N2O6 | 412.442 | 7 / 2 | 3.3 | Yes |
145833 | CHEMBL1224070 | C16H14ClN3O3 | 331.756 | 5 / 1 | 3.0 | Yes |
146285 | CHEMBL552399 | C9H15N3O2 | 197.238 | 4 / 3 | 2.1 | Yes |
147298 | 1-Propyl-1,2,3-benzotriazole-5-carboxylic acid | C10H11N3O2 | 205.217 | 4 / 1 | 1.7 | Yes |
147499 | CHEMBL3299011 | C19H18N2O3 | 322.364 | 4 / 2 | 3.3 | Yes |
148425 | CHEMBL2036954 | C13H14N2O4 | 262.265 | 4 / 2 | 1.2 | Yes |
554033 | 2-Hydroxyoctanoic acid | C8H16O3 | 160.213 | 3 / 2 | 2.0 | Yes |
157029 | CHEMBL221282 | C10H7ClO4S | 258.672 | 5 / 1 | 2.3 | Yes |
159162 | CHEMBL553415 | C8H13N3O2 | 183.211 | 4 / 3 | 1.7 | Yes |
159537 | CHEMBL564914 | C16H15N3O2S | 313.375 | 5 / 2 | 3.2 | Yes |
161776 | 6-(diethylamino)pyridine-3-carboxylic acid | C10H14N2O2 | 194.234 | 4 / 1 | 1.6 | Yes |
168709 | CHEMBL202427 | C15H13N3O3 | 283.287 | 5 / 1 | 2.2 | Yes |
169466 | CHEMBL3297873 | C19H20N2O3 | 324.38 | 4 / 2 | 3.1 | Yes |
170783 | CHEMBL373752 | C13H12O5 | 248.234 | 5 / 1 | 1.6 | Yes |
176220 | CHEMBL553912 | C16H29N3O2 | 295.427 | 4 / 2 | 5.2 | No |
177143 | 4-(methylamino)-3-nitrobenzoic acid | C8H8N2O4 | 196.162 | 5 / 2 | 1.9 | Yes |
184399 | CHEMBL3299116 | C18H21NO5 | 331.368 | 5 / 2 | 3.0 | Yes |
184899 | CHEMBL375754 | C11H12O4 | 208.213 | 4 / 1 | 1.2 | Yes |
192438 | CHEMBL394468 | C9H10N2O2 | 178.191 | 4 / 2 | 1.3 | Yes |
200430 | 6-(cyclobutylamino)nicotinic acid | C10H12N2O2 | 192.218 | 4 / 2 | 1.6 | Yes |
202090 | CHEMBL3298703 | C21H21NO3 | 335.403 | 3 / 2 | 4.1 | Yes |
204777 | CHEMBL557298 | C20H21N3O2 | 335.407 | 4 / 2 | 4.4 | Yes |
207908 | 3-nitro-4-(pyrrolidin-1-yl)benzoic acid | C11H12N2O4 | 236.227 | 5 / 1 | 1.9 | Yes |
210337 | CHEMBL3297875 | C20H21ClN2O4 | 388.848 | 5 / 2 | 4.1 | Yes |
218205 | CHEMBL396382 | C11H16N2O2 | 208.261 | 4 / 2 | 2.5 | Yes |
554370 | (3S)-3-hydroxyoctanoic acid | C8H16O3 | 160.213 | 3 / 2 | 1.4 | Yes |
221822 | CHEMBL376419 | C12H8F2O4 | 254.189 | 6 / 1 | 1.9 | Yes |
221990 | CHEMBL2036955 | C13H14N2O4 | 262.265 | 4 / 2 | 1.2 | Yes |
224052 | CHEMBL3299114 | C17H17NO5 | 315.325 | 5 / 2 | 2.9 | Yes |
224165 | CHEMBL375625 | C12H8F2O4 | 254.189 | 6 / 1 | 1.9 | Yes |
225515 | CHEMBL237077 | C12H16N2O4 | 252.27 | 5 / 2 | 3.6 | Yes |
226591 | CHEMBL222955 | C12H8Cl2O4 | 287.092 | 4 / 1 | 2.9 | Yes |
228014 | CHEMBL424938 | C11H10O4S | 238.257 | 5 / 1 | 1.8 | Yes |
229378 | CHEMBL3297797 | C18H20ClNO5 | 365.81 | 5 / 2 | 3.6 | Yes |
232132 | 6-(cyclopentylamino)nicotinic acid | C11H14N2O2 | 206.245 | 4 / 2 | 2.0 | Yes |
232541 | 4-(isopropylamino)-3-nitrobenzoic acid | C10H12N2O4 | 224.216 | 5 / 2 | 2.7 | Yes |
242416 | CHEMBL424750 | C10H7ClO4S | 258.672 | 5 / 1 | 2.4 | Yes |
244923 | 13426-16-9 | C12H10N2O2 | 214.224 | 4 / 2 | 2.3 | Yes |
248575 | 6-(isopropylamino)nicotinic acid | C9H12N2O2 | 180.207 | 4 / 2 | 1.5 | Yes |
249611 | CHEMBL3299113 | C18H17NO3 | 295.338 | 3 / 2 | 3.4 | Yes |
251082 | 3-nitro-4-(propylamino)benzoic acid | C10H12N2O4 | 224.216 | 5 / 2 | 2.7 | Yes |
251851 | CHEMBL3299015 | C20H20N2O4 | 352.39 | 5 / 2 | 3.6 | Yes |
255144 | 4-(butylamino)-3-nitrobenzoic acid | C11H14N2O4 | 238.243 | 5 / 2 | 3.1 | Yes |
258686 | 1-Cyclopentyl-1,2,3-benzotriazole-5-carboxylic acid | C12H13N3O2 | 231.255 | 4 / 1 | 2.1 | Yes |
260406 | 691363-24-3 | C11H13N3O2 | 219.244 | 4 / 1 | 1.5 | Yes |
262962 | CHEMBL396879 | C11H16N2O2 | 208.261 | 4 / 2 | 2.5 | Yes |
264566 | 4-(1-ETHYL-PROPYLAMINO)-3-NITRO-BENZOIC ACID | C12H16N2O4 | 252.27 | 5 / 2 | 3.7 | Yes |
264570 | CHEMBL564907 | C18H15F2N3O2 | 343.334 | 6 / 2 | 3.7 | Yes |
269965 | nicotinic acid | C6H5NO2 | 123.111 | 3 / 1 | 0.4 | Yes |
270004 | 6-benzamidonicotinic acid | C13H10N2O3 | 242.234 | 4 / 2 | 1.5 | Yes |
271587 | CHEMBL223566 | C11H10O4S | 238.257 | 5 / 1 | 1.8 | Yes |
278895 | 6-(pentylamino)nicotinic acid | C11H16N2O2 | 208.261 | 4 / 2 | 2.5 | Yes |
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