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GPCR

Name	Muscarinic acetylcholine receptor M2
Species	Rattus norvegicus (Rat)
Gene	Chrm2
Synonym	cholinergic receptor cholinergic receptor, muscarinic 2 AChR M2 Chrm-2 M2 muscarinic acetylcholine receptor M2 receptor cholinergic receptor, muscarinic 2, cardiac [ Show all ]
Disease	N/A for non-human GPCRs
Length	466
Amino acid sequence	MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRIVKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
UniProt	P10980
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL309
IUPHAR	14
DrugBank	N/A

Ligand

Name	pilocarpine
Molecular formula	C11H16N2O2
IUPAC name	(3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one
Molecular weight	208.261
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	1.1
Synonyms	NCGC00023339-14 AB00053525_29 Ocusert pilo Amistura P Pilocarpine (JAN/USP) BRD-K85090592-008-15-1 Pilocarpine, Monohydrochloride, (3S-cis)-Isomer CHEMBL550 Piloptic-2 DSSTox_GSID_21162 Prestwick3_000449 IDI1_000358 SDCCGMLS-0003164.P005 KBio2_001587 LS-187208 (3S,4R)-3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone NCGC00023339-06 3-Ethyl-4-(3-methyl-3H-imidazol-4-ylmethyl)dihydrofuran-2-one Spectrum5_001379 Tox21_110887 NINDS_000358 AI3-50523 Ocusert Pilo-40 BDBM50008072 Pilocarpine monohydrochloride C07474 Pilokarpin Piloptic-6 EINECS 202-128-4 Salagen (TN) Isopto carpine Spectrum2_001284 KBio3_001691 (3S,4R)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydrofuran-2(3H)-one Mi-Pilo 01MI4Q9DI3 NCGC00023339-09 SR-01000075339-11 ZINC75008 AB00053525-27 Ocusert AKOS016010311 Pilocarpin BPBio1_000548 Pilocarpine [USAN:BAN:JAN] CHEBI:8207 Piloptic-1 DivK1c_000358 Prestwick1_000449 HMS2089K17 Scheinpharm (TN) KB-207616 Lopac0_000950 (3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one Miocarpine (TN) 2(3H)-Furanone, 3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-, (3S-cis)- NCGC00023339-12 Spectrum3_000546 Timpilo (TN) NCGC00023339-16 AC1L1LEF Ocusert pilo-20 AN-42585 Pilocarpine (TN) BSPBio_000498 Pilocarpine-d3 HCl (deuterated) D00525 Piloptic-3 DSSTox_RID_75984 QCHFTSOMWOSFHM-WPRPVWTQSA-N Imidazole-5-butyric acid, alpha-ethyl-beta-(hydroxymethyl)-1-methyl-, gamma-lactone SPBio_001287 KBio2_004155 (+)-Pilocarpine LS-7661 (3S-cis)-3-Ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone NCGC00023339-07 3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one Spectrum_001107 Tox21_110887_1 91484-73-0 NSC5746 AK116461 P.V. Carpine Liquifilm beta-Pilocarpine hydrochloride Pilocarpine Mononitrate, (3S-cis)-Isomer CAS-92-13-7 Pilokarpol DB01085 Pilostat Epicar SBB012409 Isopto carpine (TN) KBioGR_000956 (3S,4R)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]oxolan-2-one Minims Pilocarpine 092P137 NCGC00023339-10 ST069319 AB00053525_28 Ocusert P 20 Almocarpine BRD-K85090592-008-05-2 Pilocarpine [USP:BAN:JAN] Piloptic-1/2 DSSTox_CID_1162 Prestwick2_000449 HSDB 3163 SCHEMBL15146 KBio1_000358 Lopac0_000960 (3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]tetrahydrofuran-2-one NCGC00023339-03 2(3H)-Furanone, 3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, (3S,4R)- NCGC00023339-13 Spectrum4_000478 Tocris-0694 NCI60_004403 Adsorbocarpine Ocusert pilo-20 (TN) AX8148055 Pilocarpine chloride BSPBio_002191 Pilocarpol D06HLY Piloptic-4 DTXSID1021162 Salagen isopilocarpine SPBio_002437 KBio2_006723 (3S,4R)-3-Ethyl-4-((1-methyl-1H-imidazol-5-yl)methyl)dihydrofuran-2(3H)-one MCULE-2634151840 (3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone NCGC00023339-08 Spersacarpine UNII-01MI4Q9DI3 92-13-7 Ocu-Carpine Akarpine Pilagan BIDD:GT0217 Pilocarpine nitrate salt CCG-205031 Pilopine HS (TN) Diocarpine (TN) Prestwick0_000449 GTPL305 SBI-0050924.P004 Isoptocarpine KBioSS_001587 (3S,4R)-3-ethyl-4-[(1-methylimidazol-5-yl)methyl]-3,4,5-trihydrofuran-2-one Miocarpine 2(3H)-Furanone, 3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-, (3S,4R)- NCGC00023339-11 Syncarpine [ Show all ]
Inchi Key	QCHFTSOMWOSFHM-WPRPVWTQSA-N
Inchi ID	InChI=1S/C11H16N2O2/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2/h5,7-8,10H,3-4,6H2,1-2H3/t8-,10-/m0/s1
PubChem CID	5910
ChEMBL	CHEMBL550
IUPHAR	305
BindingDB	50008072
DrugBank	DB01085
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	8800.0 nM	, Bioorg. Med. Chem. Lett., (1991) 1:3:147	BindingDB,ChEMBL
Intrinsic activity	48.0 %	Bioorg. Med. Chem. Lett., (1995) 5:16:1813	ChEMBL
Kd	10000.0 nM	PMID1732522	BindingDB,ChEMBL
Ki	<10000.0 nM	PMID1310135	BindingDB
Ki	7000.0 nM	PMID4151898	BindingDB
Ki	9800.0 nM	, Bioorg. Med. Chem. Lett., (1995) 5:16:1813	BindingDB,ChEMBL

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