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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Corticotropin-releasing factor receptor 1
Species	Rattus norvegicus (Rat)
Gene	Crhr1
Synonym	CRH-R1 CRH-R-1 CRFR1 CRFR-1 CRF1 receptor CRF-RA CRF-R1alpha CRF-R1 CRF-R-1 CRF-R CRF 1 receptor Corticotropin-releasing hormone receptor 1 CRHR [ Show all ]
Disease	N/A for non-human GPCRs
Length	415
Amino acid sequence	MGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEVHQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPFPIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
UniProt	P35353
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4649
IUPHAR	212
DrugBank	N/A

Ligand

Name	CHEMBL272804
Molecular formula	C23H33NO2
IUPAC name	3-ethyl-2,5-dimethyl-4-pentan-3-yloxy-6-(2,4,6-trimethylphenoxy)pyridine
Molecular weight	355.522
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	7.2
Synonyms	2-Aryloxy-4-alkoxy-pyridine, 25 BDBM20944 3-ethyl-2,5-dimethyl-4-(pentan-3-yloxy)-6-(2,4,6-trimethylphenoxy)pyridine
Inchi Key	CQDRMTZWDCKCMS-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H33NO2/c1-9-19(10-2)25-22-17(7)23(24-18(8)20(22)11-3)26-21-15(5)12-14(4)13-16(21)6/h12-13,19H,9-11H2,1-8H3
PubChem CID	24768325
ChEMBL	CHEMBL272804
IUPHAR	N/A
BindingDB	20944
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<10000.0 nM	PMID18260619	BindingDB,ChEMBL
IC50	>10000.0 nM	PMID18260619	ChEMBL

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