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GPCR

NameTaste receptor type 2 member 8
SpeciesHomo sapiens (Human)
GeneTAS2R8
SynonymT2R8
TAS2R8
Taste receptor family B member 5
taste receptor, type 2, member 8
TRB5
DiseaseN/A
Length309
Amino acid sequenceMFSPADNIFIILITGEFILGILGNGYIALVNWIDWIKKKKISTVDYILTNLVIARICLISVMVVNGIVIVLNPDVYTKNKQQIVIFTFWTFANYLNMWITTCLNVFYFLKIASSSHPLFLWLKWKIDMVVHWILLGCFAISLLVSLIAAIVLSCDYRFHAIAKHKRNITEMFHVSKIPYFEPLTLFNLFAIVPFIVSLISFFLLVRSLWRHTKQIKLYATGSRDPSTEVHVRAIKTMTSFIFFFFLYYISSILMTFSYLMTKYKLAVEFGEIAAILYPLGHSLILIVLNNKLRQTFVRMLTCRKIACMI
UniProtQ9NYW2
Protein Data BankN/A
GPCR-HGmod modelQ9NYW2
3D structure modelThis predicted structure model is from GPCR-EXP Q9NYW2.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3988599
IUPHARN/A
DrugBankN/A

Ligand

NameSCHEMBL1279520
Molecular formulaC22H25N5O4
IUPAC name3-[1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]pyrazol-4-yl]-1-[[3-(hydroxymethyl)phenyl]methyl]-5,5-dimethylimidazolidine-2,4-dione
Molecular weight423.473
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP1.2
Synonyms3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-1-(3-(hydroxymethyl)benzyl)-5,5-dimethylimidazolidine-2,4-dione
US9247759, 12-34
BDBM211383
CHEMBL3941755
CCFDOSTXMHLBFB-UHFFFAOYSA-N
Inchi KeyCCFDOSTXMHLBFB-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H25N5O4/c1-14-19(15(2)31-24-14)12-25-11-18(9-23-25)27-20(29)22(3,4)26(21(27)30)10-16-6-5-7-17(8-16)13-28/h5-9,11,28H,10,12-13H2,1-4H3
PubChem CID53373961
ChEMBLCHEMBL3941755
IUPHARN/A
BindingDB211383
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50110.0 nMNoneChEMBL
IC50110.0 nMN/ABindingDB

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