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GPCR

NameTaste receptor type 2 member 8
SpeciesHomo sapiens (Human)
GeneTAS2R8
SynonymT2R8
TAS2R8
Taste receptor family B member 5
taste receptor, type 2, member 8
TRB5
DiseaseN/A
Length309
Amino acid sequenceMFSPADNIFIILITGEFILGILGNGYIALVNWIDWIKKKKISTVDYILTNLVIARICLISVMVVNGIVIVLNPDVYTKNKQQIVIFTFWTFANYLNMWITTCLNVFYFLKIASSSHPLFLWLKWKIDMVVHWILLGCFAISLLVSLIAAIVLSCDYRFHAIAKHKRNITEMFHVSKIPYFEPLTLFNLFAIVPFIVSLISFFLLVRSLWRHTKQIKLYATGSRDPSTEVHVRAIKTMTSFIFFFFLYYISSILMTFSYLMTKYKLAVEFGEIAAILYPLGHSLILIVLNNKLRQTFVRMLTCRKIACMI
UniProtQ9NYW2
Protein Data BankN/A
GPCR-HGmod modelQ9NYW2
3D structure modelThis predicted structure model is from GPCR-EXP Q9NYW2.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3988599
IUPHARN/A
DrugBankN/A

Ligand

NameSCHEMBL1279621
Molecular formulaC17H15N5O3
IUPAC name3-[1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]pyrazol-4-yl]-1H-quinazoline-2,4-dione
Molecular weight337.339
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP1.3
Synonyms3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)quinazoline-2,4(1H,3H)-dione
COARNZHGJWPZAE-UHFFFAOYSA-N
CHEMBL3978413
Inchi KeyCOARNZHGJWPZAE-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H15N5O3/c1-10-14(11(2)25-20-10)9-21-8-12(7-18-21)22-16(23)13-5-3-4-6-15(13)19-17(22)24/h3-8H,9H2,1-2H3,(H,19,24)
PubChem CID57422414
ChEMBLCHEMBL3978413
IUPHARN/A
BindingDB211247
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC501500.0 nMN/ABindingDB
IC501500.0 nMNoneChEMBL

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