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GPCR

NameTaste receptor type 2 member 8
SpeciesHomo sapiens (Human)
GeneTAS2R8
SynonymT2R8
TAS2R8
Taste receptor family B member 5
taste receptor, type 2, member 8
TRB5
DiseaseN/A
Length309
Amino acid sequenceMFSPADNIFIILITGEFILGILGNGYIALVNWIDWIKKKKISTVDYILTNLVIARICLISVMVVNGIVIVLNPDVYTKNKQQIVIFTFWTFANYLNMWITTCLNVFYFLKIASSSHPLFLWLKWKIDMVVHWILLGCFAISLLVSLIAAIVLSCDYRFHAIAKHKRNITEMFHVSKIPYFEPLTLFNLFAIVPFIVSLISFFLLVRSLWRHTKQIKLYATGSRDPSTEVHVRAIKTMTSFIFFFFLYYISSILMTFSYLMTKYKLAVEFGEIAAILYPLGHSLILIVLNNKLRQTFVRMLTCRKIACMI
UniProtQ9NYW2
Protein Data BankN/A
GPCR-HGmod modelQ9NYW2
3D structure modelThis predicted structure model is from GPCR-EXP Q9NYW2.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3988599
IUPHARN/A
DrugBankN/A

Ligand

NameSCHEMBL1615620
Molecular formulaC23H25N5O5
IUPAC name1-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-3-[1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]pyrazol-4-yl]-5,5-dimethylimidazolidine-2,4-dione
Molecular weight451.483
Hydrogen bond acceptor7
Hydrogen bond donor0
XlogP1.8
SynonymsCHEMBL3963093
BDBM211411
US9247759, 12-62
Inchi KeyFBXKJTLHZAMBEP-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H25N5O5/c1-14-18(15(2)33-25-14)13-26-12-17(10-24-26)28-21(29)23(3,4)27(22(28)30)11-16-5-6-19-20(9-16)32-8-7-31-19/h5-6,9-10,12H,7-8,11,13H2,1-4H3
PubChem CID53374382
ChEMBLCHEMBL3963093
IUPHARN/A
BindingDB211411
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50270.0 nMNoneChEMBL
IC50270.0 nMN/ABindingDB

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