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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Taste receptor type 2 member 8
Species	Homo sapiens (Human)
Gene	TAS2R8
Synonym	T2R8 TAS2R8 Taste receptor family B member 5 taste receptor, type 2, member 8 TRB5
Disease	N/A
Length	309
Amino acid sequence	MFSPADNIFIILITGEFILGILGNGYIALVNWIDWIKKKKISTVDYILTNLVIARICLISVMVVNGIVIVLNPDVYTKNKQQIVIFTFWTFANYLNMWITTCLNVFYFLKIASSSHPLFLWLKWKIDMVVHWILLGCFAISLLVSLIAAIVLSCDYRFHAIAKHKRNITEMFHVSKIPYFEPLTLFNLFAIVPFIVSLISFFLLVRSLWRHTKQIKLYATGSRDPSTEVHVRAIKTMTSFIFFFFLYYISSILMTFSYLMTKYKLAVEFGEIAAILYPLGHSLILIVLNNKLRQTFVRMLTCRKIACMI
UniProt	Q9NYW2
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYW2
3D structure model	This predicted structure model is from GPCR-EXP Q9NYW2.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3988599
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1279261
Molecular formula	C14H15N5O2
IUPAC name	N-[1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]pyrazol-4-yl]-1H-pyrrole-2-carboxamide
Molecular weight	285.307
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	1.0
Synonyms	FXIZELTUWWZXPP-UHFFFAOYSA-N US9247759, 4-13 N-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-1H-pyrrole-2-carboxamide CHEMBL3963524 BDBM210979
Inchi Key	FXIZELTUWWZXPP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H15N5O2/c1-9-12(10(2)21-18-9)8-19-7-11(6-16-19)17-14(20)13-4-3-5-15-13/h3-7,15H,8H2,1-2H3,(H,17,20)
PubChem CID	57422271
ChEMBL	CHEMBL3963524
IUPHAR	N/A
BindingDB	210979
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	570.0 nM	None	ChEMBL
IC50	570.0 nM	N/A	BindingDB

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