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GPCR

NameTaste receptor type 2 member 8
SpeciesHomo sapiens (Human)
GeneTAS2R8
SynonymT2R8
TAS2R8
Taste receptor family B member 5
taste receptor, type 2, member 8
TRB5
DiseaseN/A
Length309
Amino acid sequenceMFSPADNIFIILITGEFILGILGNGYIALVNWIDWIKKKKISTVDYILTNLVIARICLISVMVVNGIVIVLNPDVYTKNKQQIVIFTFWTFANYLNMWITTCLNVFYFLKIASSSHPLFLWLKWKIDMVVHWILLGCFAISLLVSLIAAIVLSCDYRFHAIAKHKRNITEMFHVSKIPYFEPLTLFNLFAIVPFIVSLISFFLLVRSLWRHTKQIKLYATGSRDPSTEVHVRAIKTMTSFIFFFFLYYISSILMTFSYLMTKYKLAVEFGEIAAILYPLGHSLILIVLNNKLRQTFVRMLTCRKIACMI
UniProtQ9NYW2
Protein Data BankN/A
GPCR-HGmod modelQ9NYW2
3D structure modelThis predicted structure model is from GPCR-EXP Q9NYW2.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3988599
IUPHARN/A
DrugBankN/A

Ligand

NameSCHEMBL1279105
Molecular formulaC19H18N6O4
IUPAC name1-benzyl-3-[1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]pyrazol-4-yl]-1,3,5-triazinane-2,4,6-trione
Molecular weight394.391
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP1.4
SynonymsCHEMBL3982487
US9247759, 9-9
BDBM211252
HSSHBWJTUDSFPP-UHFFFAOYSA-N
1-benzyl-3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-1,3,5-triazinane-2,4,6-trione
Inchi KeyHSSHBWJTUDSFPP-UHFFFAOYSA-N
Inchi IDInChI=1S/C19H18N6O4/c1-12-16(13(2)29-22-12)11-23-10-15(8-20-23)25-18(27)21-17(26)24(19(25)28)9-14-6-4-3-5-7-14/h3-8,10H,9,11H2,1-2H3,(H,21,26,27)
PubChem CID57422423
ChEMBLCHEMBL3982487
IUPHARN/A
BindingDB211252
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC501140.0 nMN/ABindingDB
IC501140.0 nMNoneChEMBL

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