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Name | Corticotropin-releasing factor receptor 1 |
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Species | Rattus norvegicus (Rat) |
Gene | Crhr1 |
Synonym | CRH-R1 CRH-R-1 CRFR1 CRFR-1 CRF1 receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 415 |
Amino acid sequence | MGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEVHQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPFPIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV |
UniProt | P35353 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4649 |
IUPHAR | 212 |
DrugBank | N/A |
Name | CHEMBL3798004 |
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Molecular formula | C23H23ClF3N5O3 |
IUPAC name | 5-chloro-1-[(1S)-1-cyclopropyl-2-[5-(trifluoromethyl)pyridin-2-yl]oxyethyl]-3-[(6-methoxy-2,5-dimethylpyridin-3-yl)amino]pyrazin-2-one |
Molecular weight | 509.914 |
Hydrogen bond acceptor | 9 |
Hydrogen bond donor | 1 |
XlogP | 4.3 |
Synonyms | N/A |
Inchi Key | AHGQHBVPJHGUHP-QGZVFWFLSA-N |
Inchi ID | InChI=1S/C23H23ClF3N5O3/c1-12-8-16(13(2)29-21(12)34-3)30-20-22(33)32(10-18(24)31-20)17(14-4-5-14)11-35-19-7-6-15(9-28-19)23(25,26)27/h6-10,14,17H,4-5,11H2,1-3H3,(H,30,31)/t17-/m1/s1 |
PubChem CID | 127047548 |
ChEMBL | CHEMBL3798004 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 1.6 nM | PMID27020524 | ChEMBL |
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