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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Corticotropin-releasing factor receptor 1
Species	Rattus norvegicus (Rat)
Gene	Crhr1
Synonym	CRH-R1 CRH-R-1 CRFR1 CRFR-1 CRF1 receptor CRF-RA CRF-R1alpha CRF-R1 CRF-R-1 CRF-R CRF 1 receptor Corticotropin-releasing hormone receptor 1 CRHR [ Show all ]
Disease	N/A for non-human GPCRs
Length	415
Amino acid sequence	MGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEVHQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPFPIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
UniProt	P35353
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4649
IUPHAR	212
DrugBank	N/A

Ligand

Name	CHEMBL3798497
Molecular formula	C25H29ClN6O5
IUPAC name	[(2S)-2-[5-chloro-3-[(6-methoxy-2,5-dimethylpyridin-3-yl)amino]-2-oxopyrazin-1-yl]-2-cyclopropylethyl] N-(6-methoxy-2-methylpyridin-3-yl)carbamate
Molecular weight	528.994
Hydrogen bond acceptor	8
Hydrogen bond donor	2
XlogP	3.4
Synonyms	SCHEMBL12612907
Inchi Key	CWJXZPJHYATFGA-LJQANCHMSA-N
Inchi ID	InChI=1S/C25H29ClN6O5/c1-13-10-18(15(3)28-23(13)36-5)29-22-24(33)32(11-20(26)31-22)19(16-6-7-16)12-37-25(34)30-17-8-9-21(35-4)27-14(17)2/h8-11,16,19H,6-7,12H2,1-5H3,(H,29,31)(H,30,34)/t19-/m1/s1
PubChem CID	58280029
ChEMBL	CHEMBL3798497
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	9.2 nM	PMID27020524	ChEMBL

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