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Name | Corticotropin-releasing factor receptor 1 |
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Species | Rattus norvegicus (Rat) |
Gene | Crhr1 |
Synonym | CRH-R1 CRH-R-1 CRFR1 CRFR-1 CRF1 receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 415 |
Amino acid sequence | MGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEVHQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPFPIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV |
UniProt | P35353 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4649 |
IUPHAR | 212 |
DrugBank | N/A |
Name | CHEMBL550216 |
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Molecular formula | C17H15Cl3F3N3O2 |
IUPAC name | 5-chloro-1-[(1R)-1-cyclopropyl-2-methoxyethyl]-3-[2,6-dichloro-4-(trifluoromethyl)anilino]pyrazin-2-one |
Molecular weight | 456.671 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 1 |
XlogP | 4.5 |
Synonyms | BDBM50293925 (R)-5-Chloro-1-(1-cyclopropyl-2-methoxyethyl)-3-[2,6-dichloro-4-(trifluoromethyl)phenylamino]pyrazin-2(1H)-one |
Inchi Key | DYIVSGDVNIYLSL-LBPRGKRZSA-N |
Inchi ID | InChI=1S/C17H15Cl3F3N3O2/c1-28-7-12(8-2-3-8)26-6-13(20)24-15(16(26)27)25-14-10(18)4-9(5-11(14)19)17(21,22)23/h4-6,8,12H,2-3,7H2,1H3,(H,24,25)/t12-/m0/s1 |
PubChem CID | 44191010 |
ChEMBL | CHEMBL550216 |
IUPHAR | N/A |
BindingDB | 50293925 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
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IC50 | 1.6 nM | PMID19552436 | BindingDB,ChEMBL |
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