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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Corticotropin-releasing factor receptor 1
Species	Rattus norvegicus (Rat)
Gene	Crhr1
Synonym	CRH-R1 CRH-R-1 CRFR1 CRFR-1 CRF1 receptor CRF-RA CRF-R1alpha CRF-R1 CRF-R-1 CRF-R CRF 1 receptor Corticotropin-releasing hormone receptor 1 CRHR [ Show all ]
Disease	N/A for non-human GPCRs
Length	415
Amino acid sequence	MGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEVHQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPFPIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
UniProt	P35353
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4649
IUPHAR	212
DrugBank	N/A

Ligand

Name	CHEMBL1083590
Molecular formula	C17H20F3N5O2
IUPAC name	1-(1-cyclopropylpropyl)-5-[[6-methoxy-2-(trifluoromethyl)pyridin-3-yl]amino]-3-methyl-1,2,4-triazin-6-one
Molecular weight	383.375
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	2.8
Synonyms	BDBM50320252 1-(1-cyclopropylpropyl)-5-(6-methoxy-2-(trifluoromethyl)pyridin-3-ylamino)-3-methyl-1,2,4-triazin-6(1H)-one
Inchi Key	FFWHWKFBSHLABO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H20F3N5O2/c1-4-12(10-5-6-10)25-16(26)15(21-9(2)24-25)22-11-7-8-13(27-3)23-14(11)17(18,19)20/h7-8,10,12H,4-6H2,1-3H3,(H,21,22,24)
PubChem CID	46891231
ChEMBL	CHEMBL1083590
IUPHAR	N/A
BindingDB	50320252
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	3.7 nM	PMID20483614	BindingDB,ChEMBL

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