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GPCR

Name	Vasopressin V1b receptor
Species	Homo sapiens (Human)
Gene	AVPR1B
Synonym	AVPR3 Vasopressin V3 receptor vasopressin V1b receptor V3/V1b pituitary vasopressin receptor V3 V1bR V1B receptor Antidiuretic hormone receptor 1b AVPR V1b AVPR V3 VPR3 [ Show all ]
Disease	Anxiety disorder Major depressive disorder; Anxiety Major depressive disorder
Length	424
Amino acid sequence	MDSGPLWDANPTPRGTLSAPNATTPWLGRDEELAKVEIGVLATVLVLATGGNLAVLLTLGQLGRKRSRMHLFVLHLALTDLAVALFQVLPQLLWDITYRFQGPDLLCRAVKYLQVLSMFASTYMLLAMTLDRYLAVCHPLRSLQQPGQSTYLLIAAPWLLAAIFSLPQVFIFSLREVIQGSGVLDCWADFGFPWGPRAYLTWTTLAIFVLPVTMLTACYSLICHEICKNLKVKTQAWRVGGGGWRTWDRPSPSTLAATTRGLPSRVSSINTISRAKIRTVKMTFVIVLAYIACWAPFFSVQMWSVWDKNAPDEDSTNVAFTISMLLGNLNSCCNPWIYMGFNSHLLPRPLRHLACCGGPQPRMRRRLSDGSLSSRHTTLLTRSSCPATLSLSLSLTLSGRPRPEESPRDLELADGEGTAETIIF
UniProt	P47901
Protein Data Bank	N/A
GPCR-HGmod model	P47901
3D structure model	This predicted structure model is from GPCR-EXP P47901.
BioLiP	N/A
Therapeutic Target Database	T59881
ChEMBL	CHEMBL1921
IUPHAR	367
DrugBank	BE0000773

Ligand

Name	MLS000778454
Molecular formula	C16H18N4O2S
IUPAC name	N,N-diethyl-3-imidazo[1,2-a]pyrimidin-2-ylbenzenesulfonamide
Molecular weight	330.406
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	2.7
Synonyms	cid_829953 N,N-diethyl-3-(imidazo[1,2-a]pyrimidin-2-yl)benzenesulfonamide AKOS002747835 IDI1_003936 SMR000415248 CHEMBL1321896 MolPort-000-316-602 STL300089 720671-03-4 HMS1383N07 N,N-Diethyl-3-imidazo[1,2-a]pyrimidin-2-yl-benzenesulfonamide BDBM100084 MCULE-8773923707 SR-01000088050 ChemDiv2_005221 N,N-diethyl-3-(2-imidazo[1,2-a]pyrimidinyl)benzenesulfonamide ZINC352194 AC1LH078 HMS2755E18 N,N-diethyl-3-imidazo[1,2-a]pyrimidin-2-ylbenzenesulfonamide SR-01000088050-1 [ Show all ]
Inchi Key	FSVIUTVROGEWCC-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H18N4O2S/c1-3-20(4-2)23(21,22)14-8-5-7-13(11-14)15-12-19-10-6-9-17-16(19)18-15/h5-12H,3-4H2,1-2H3
PubChem CID	829953
ChEMBL	CHEMBL1321896
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	15477.2 nM	PubChem BioAssay data set	ChEMBL

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