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Name | Muscarinic acetylcholine receptor M4 |
---|---|
Species | Homo sapiens (Human) |
Gene | CHRM4 |
Synonym | HM3 M4 receptor cholinergic receptor Chrm-4 cholinergic receptor, muscarinic 4 |
Disease | Produce mydriasis and cycloplegia for diagnostic purposes Hypertension Irritable bowel syndrome Moderate and severe psychomotor agitation Mydriasis diagnosis [ Show all ] |
Length | 479 |
Amino acid sequence | MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR |
UniProt | P08173 |
Protein Data Bank | 5dsg |
GPCR-HGmod model | P08173 |
3D structure model | This structure is from PDB ID 5dsg. |
BioLiP | BL0339919,BL0339921, BL0339920 |
Therapeutic Target Database | T20709, T50918 |
ChEMBL | CHEMBL1821 |
IUPHAR | 16 |
DrugBank | BE0000405 |
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GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
---|---|---|---|---|---|---|
441677 | CHEMBL1602658 | C23H28N2O5S | 444.546 | 6 / 0 | 2.6 | Yes |
526 | CHEMBL2407175 | C24H36N4O3 | 428.577 | 5 / 0 | 2.7 | Yes |
1009 | CHEMBL2205816 | C18H20N2O | 280.371 | 3 / 1 | 1.8 | Yes |
1276 | CHEMBL141736 | C24H29N2O2+ | 377.508 | 2 / 0 | 2.8 | Yes |
1942 | CHEMBL282874 | C20H20N2O | 304.393 | 2 / 1 | 3.5 | Yes |
2272 | 1-(cyclohexylmethyl)pyrrolidine | C11H21N | 167.296 | 1 / 0 | 3.1 | Yes |
2909 | CHEMBL282680 | C19H18N2O2 | 306.365 | 3 / 1 | 2.6 | Yes |
3062 | Genostrychnine | C21H22N2O3 | 350.418 | 3 / 0 | 1.4 | Yes |
3137 | AC1N0YGA | C3H7NO4S | 153.152 | 5 / 2 | -4.7 | Yes |
3656 | CHEMBL23620 | C23H23N3O3 | 389.455 | 4 / 1 | 1.7 | Yes |
3848 | CEP-11981 | C28H27N7O | 477.572 | 5 / 2 | 3.9 | Yes |
4010 | CHEMBL215894 | C37H41Cl3N4O4 | 712.109 | 5 / 3 | 5.9 | No |
4317 | sulconazole | C18H15Cl3N2S | 397.742 | 2 / 0 | 6.1 | No |
4989 | CHEMBL255692 | C36H46Cl2N2O2 | 609.676 | 4 / 4 | N/A | No |
5753 | AHOUBRCZNHFOSL-UHFFFAOYSA-N | C19H20FNO3 | 329.371 | 5 / 1 | 3.5 | Yes |
5763 | paroxetine | C19H20FNO3 | 329.371 | 5 / 1 | 3.5 | Yes |
553273 | WIN-51708 | C29H33N3O | 439.603 | 3 / 1 | 6.5 | No |
6331 | BDBM86295 | C12H16N3O2+ | 234.279 | 2 / 0 | 0.0 | Yes |
6606 | carbachol | C6H15ClN2O2 | 182.648 | 3 / 1 | N/A | N/A |
6682 | CHEMBL214029 | C38H43F3N4O4 | 676.781 | 8 / 3 | 4.7 | No |
6834 | CID 49797317 | C14H18N2O6 | 310.306 | 8 / 2 | N/A | N/A |
463734 | CHEMBL3633757 | C26H24BrNO4 | 494.385 | 5 / 0 | 5.4 | No |
7189 | CHEMBL2024331 | C23H33N3O3 | 399.535 | 4 / 1 | 3.6 | Yes |
521664 | CHEMBL3808947 | C22H29N5S | 395.569 | 6 / 0 | 5.4 | No |
7655 | CHEMBL84113 | C14H17NO2 | 231.295 | 3 / 1 | 2.5 | Yes |
7778 | CHEMBL376295 | C19H25N5O5S2 | 467.559 | 12 / 0 | 2.8 | No |
521714 | CHEMBL3808592 | C21H24N4O3S2 | 444.568 | 7 / 1 | 3.3 | Yes |
9535 | Glycopyrronium | C19H28NO3+ | 318.437 | 3 / 1 | 3.1 | Yes |
9866 | AC-42 | C20H31NO | 301.474 | 2 / 0 | 5.2 | No |
9910 | CHEMBL403773 | C42H52N2O2 | 616.89 | 4 / 2 | 7.9 | No |
10172 | CHEMBL194206 | C23H30FN5O2 | 427.524 | 6 / 1 | 2.7 | Yes |
10391 | N-Allyl Brucine Iodide | C26H31N2O4+ | 435.544 | 4 / 0 | 1.6 | Yes |
10708 | CHEMBL213709 | C39H45F3N4O4 | 690.808 | 8 / 2 | 5.1 | No |
10721 | CHEMBL3287723 | C25H32O7 | 444.524 | 7 / 2 | 5.7 | No |
10914 | CHEMBL169494 | C19H22N2 | 278.399 | 2 / 0 | 2.4 | Yes |
11918 | CHEMBL477821 | C24H29ClN4O | 424.973 | 3 / 1 | 4.1 | Yes |
12544 | CHEMBL593620 | C11H24INO2 | 329.222 | 3 / 0 | N/A | N/A |
12549 | CHEMBL593685 | C11H24INO2 | 329.222 | 3 / 0 | N/A | N/A |
12703 | CHEMBL1083925 | C20H22ClFN2O | 360.857 | 3 / 2 | 4.3 | Yes |
12819 | CHEMBL85190 | C15H19NO2 | 245.322 | 3 / 0 | 3.0 | Yes |
13309 | Aclidinium | C26H30NO4S2+ | 484.649 | 6 / 1 | 4.7 | Yes |
13781 | CHEMBL557808 | C19H30INO2S | 463.418 | 4 / 0 | N/A | N/A |
14003 | CHEMBL1922764 | C19H20ClNO2 | 329.824 | 3 / 0 | 5.7 | No |
15153 | cremastrine | C14H25NO3 | 255.358 | 4 / 1 | 2.2 | Yes |
15430 | CHEMBL568775 | C23H32NO2+ | 354.514 | 2 / 1 | 4.4 | Yes |
15434 | CHEMBL569089 | C23H32NO2+ | 354.514 | 2 / 1 | 4.4 | Yes |
15438 | CHEMBL569307 | C23H32NO2+ | 354.514 | 2 / 1 | 4.4 | Yes |
15445 | CHEMBL568870 | C23H32NO2+ | 354.514 | 2 / 1 | 4.4 | Yes |
15451 | CHEMBL569760 | C23H32NO2+ | 354.514 | 2 / 1 | 4.4 | Yes |
15471 | CHEMBL2205829 | C19H19NO3 | 309.365 | 4 / 1 | 2.2 | Yes |
15783 | CID 44448670 | C21H28ClNO | 345.911 | 2 / 2 | N/A | N/A |
442263 | CHEMBL3354075 | C26H42N2O2 | 414.634 | 3 / 1 | 5.7 | No |
521953 | AM-0902 | C17H15ClN6O2 | 370.797 | 6 / 0 | 2.3 | Yes |
16574 | CHEMBL2059306 | C24H28N4O2 | 404.514 | 3 / 1 | 3.8 | Yes |
20177 | imipramine | C19H24N2 | 280.415 | 2 / 0 | 4.8 | Yes |
20543 | AQ-RA 741 | C27H37N5O2 | 463.626 | 5 / 1 | 3.1 | Yes |
536501 | CHEMBL3974708 | C17H18N4O3S2 | 390.476 | 7 / 2 | 2.2 | Yes |
20975 | CHEMBL62247 | C24H26N2O4 | 406.482 | 5 / 1 | 4.2 | Yes |
21628 | AC1L7RMR | C20H25NO2S | 343.485 | 4 / 1 | 4.0 | Yes |
22069 | CHEMBL568775 | C23H32INO2 | 481.418 | 3 / 1 | N/A | N/A |
22074 | CHEMBL569760 | C23H32INO2 | 481.418 | 3 / 1 | N/A | N/A |
22076 | CHEMBL569089 | C23H32INO2 | 481.418 | 3 / 1 | N/A | N/A |
22080 | CHEMBL568870 | C23H32INO2 | 481.418 | 3 / 1 | N/A | N/A |
22089 | CHEMBL569307 | C23H32INO2 | 481.418 | 3 / 1 | N/A | N/A |
522128 | CHEMBL3775436 | C15H26ClNO3 | 303.827 | 4 / 3 | N/A | N/A |
522181 | CHEMBL3775769 | C15H26ClNO3 | 303.827 | 4 / 3 | N/A | N/A |
22179 | suloctidil | C20H35NOS | 337.566 | 3 / 2 | 5.8 | No |
22243 | CHEMBL2111540 | C25H31N3O2S | 437.602 | 6 / 0 | 4.1 | Yes |
22245 | CHEMBL2114066 | C25H31N3O2S | 437.602 | 6 / 0 | 4.1 | Yes |
22550 | CHEMBL283036 | C19H19F3N4 | 360.384 | 6 / 1 | 3.6 | Yes |
22873 | tropicamide | C17H20N2O2 | 284.359 | 3 / 1 | 1.5 | Yes |
23578 | CHEMBL378872 | C37H41Cl3N4O4 | 712.109 | 5 / 3 | 5.9 | No |
24595 | CHEMBL262198 | C24H27NO6 | 425.481 | 7 / 2 | N/A | N/A |
24636 | CHEMBL540316 | C23H28ClNO2 | 385.932 | 3 / 1 | N/A | N/A |
25533 | CHEMBL2313391 | C18H16ClN3O3S | 389.854 | 6 / 2 | 4.4 | Yes |
25801 | CHEMBL2042406 | C20H26INO2 | 439.337 | 3 / 0 | N/A | N/A |
25806 | CHEMBL2042405 | C20H26INO2 | 439.337 | 3 / 0 | N/A | N/A |
25808 | CHEMBL2042404 | C20H26INO2 | 439.337 | 3 / 0 | N/A | N/A |
522354 | CHEMBL1314270 | C20H20Cl2N4OS | 435.367 | 5 / 1 | 5.4 | No |
26382 | CHEMBL105122 | C23H24N2O3S | 408.516 | 5 / 1 | 4.4 | Yes |
26439 | CHEMBL304036 | C23H24N2O3 | 376.456 | 4 / 1 | 4.3 | Yes |
26453 | CHEMBL1202234 | C29H31BrN2O2 | 519.483 | 3 / 0 | N/A | No |
26526 | CHEMBL2042553 | C21H25NO6 | 387.432 | 7 / 2 | N/A | N/A |
26528 | CHEMBL2042554 | C21H25NO6 | 387.432 | 7 / 2 | N/A | N/A |
26535 | CHEMBL2042552 | C21H25NO6 | 387.432 | 7 / 2 | N/A | N/A |
26938 | terconazole | C26H31Cl2N5O3 | 532.466 | 7 / 0 | 4.8 | No |
27203 | CHEMBL2203713 | C18H22N4S | 326.462 | 4 / 2 | 2.9 | Yes |
27267 | CHEMBL315428 | C14H16N2O4 | 276.292 | 5 / 1 | 2.3 | Yes |
27495 | CHEMBL2432063 | C19H29N | 271.448 | 1 / 0 | 4.7 | Yes |
28360 | CHEMBL593685 | C11H24NO2+ | 202.318 | 2 / 0 | 0.9 | Yes |
28362 | CHEMBL593620 | C11H24NO2+ | 202.318 | 2 / 0 | 0.9 | Yes |
28524 | CHEMBL197796 | C24H33N5O2S | 455.621 | 6 / 1 | 3.1 | Yes |
28620 | CHEMBL352779 | C20H23N3O | 321.424 | 3 / 1 | 2.2 | Yes |
28871 | CHEMBL280340 | C22H24N2O3 | 364.445 | 4 / 1 | 3.4 | Yes |
28941 | CHEMBL2407171 | C20H28N4O4 | 388.468 | 6 / 1 | 1.7 | Yes |
29603 | CHEMBL2336054 | C21H29N3O3 | 371.481 | 4 / 0 | 2.2 | Yes |
29609 | CHEMBL2336055 | C21H29N3O3 | 371.481 | 4 / 0 | 2.2 | Yes |
31077 | CHEMBL105674 | C22H21ClN2O3 | 396.871 | 4 / 1 | 4.5 | Yes |
31813 | CP-810123 | C14H18N4O | 258.325 | 5 / 0 | 2.2 | Yes |
31976 | CHEMBL170088 | C22H28N2 | 320.48 | 2 / 0 | 3.6 | Yes |
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