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You can:

Check the GPCR table for details.
Go to the ligand list to see ligands that interacts with this GPCR.
Go to the individual ligand page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
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GPCR

Name	Substance-P receptor
Species	Homo sapiens (Human)
Gene	TACR1
Synonym	NK-1 receptor Tachykinin receptor 1 TAC1R SPR Substance P receptor neurokinin receptor 1 NK1R NK-1R NK1 receptor [ Show all ]
Disease	Cough Depression Depression; Anxiety Diabetes Eczema Nausea; Vomiting Emesis; Irritable bowel syndrome Incontinence; Anxiety disorder; Chemotherapyinduced emesis; Major depressive disorder Influenza virus Irritable bowel syndrome; Chemo therapy induced emesis; Gastric motility disorder Major depressive disorder Migraine Urinary incontinence Chemotherapy-induced nausea Cancer pain Alcohol use disorders Asthma Emesis Overactive bladder disorder Pain Respiratory tract inflammation Schizophrenia Severe mood disorders; Depression Unspecified Brain injury Mood disorder [ Show all ]
Length	407
Amino acid sequence	MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
UniProt	P25103
Protein Data Bank	2ksa, 6e59, 6hlo, 2ks9, 6hlp, 6hll, 2ksb
GPCR-HGmod model	P25103
3D structure model	This structure is from PDB ID 2ksa.
BioLiP	BL0101802, BL0437915, BL0437914, BL0437913, BL0434896, BL0101803, BL0101801
Therapeutic Target Database	T47094
ChEMBL	CHEMBL249
IUPHAR	360
DrugBank	BE0000384

Known ligands

You can:

Click GLASS IDs to check the association information.
Click ligand names to check details of the ligands.
Download a TSV version of all interaction information.
Download a SDF structure collection of all known ligands.

GLASS ID	Molecule	Formula	Molecular weight	H-bond acceptor / donor	XlogP	Lipinski's druglikeness
312	CHEMBL358600	C27H32Cl2FN3O2	520.47	5 / 0	4.3	No
347	CHEMBL1097693	C23H21F7N2O2	490.422	10 / 1	4.3	Yes
396	CHEMBL3288163	C34H39Cl3FN5O4	707.065	7 / 4	N/A	No
777	CHEMBL408242	C36H37Cl2N3O2S	646.671	5 / 0	7.5	No
1038	CHEMBL21607	C28H27Cl2N3O2	508.443	3 / 1	6.1	No
1104	CHEMBL143156	C27H30F6N2O2	528.539	9 / 0	5.6	No
1179	CHEMBL134737	C28H28ClN3O3	490.0	3 / 3	5.6	No
1274	CHEMBL418757	C51H52FN7O7	894.017	8 / 7	6.6	No
1512	CHEMBL556537	C70H89F6N11O15	1438.53	22 / 14	5.8	No
1580	CHEMBL417766	C28H33NO	399.578	2 / 1	6.1	No
1623	CHEMBL21939	C35H35N3O2	529.684	3 / 1	7.0	No
1720	CHEMBL2373196	C34H36Cl2N2O2S	607.634	4 / 0	7.4	No
1836	CHEMBL2304114	C97H126N18O19S	1880.24	21 / 15	7.8	No
1876	CHEMBL327928	C21H25NO2	323.436	3 / 1	3.4	Yes
1889	CHEMBL76455	C32H33N3O4	523.633	4 / 3	6.3	No
2342	CHEMBL59310	C26H29NO2	387.523	2 / 1	5.1	No
2488	Substance P	C63H98N18O13S	1347.65	17 / 15	-2.3	No
2798	sub-stance p	C63H98N18O13S	1347.65	17 / 15	-2.3	No
463228	CHEMBL3609619	C32H30F6N4O5	664.605	12 / 5	4.5	No
3121	CHEMBL400148	C26H24F7NO2	515.472	10 / 0	6.2	No
3175	CHEMBL557188	C60H72F6N10O9	1191.29	16 / 10	7.4	No
3187	CHEMBL42653	C31H32ClN3O4	546.064	4 / 2	4.5	No
3200	CHEMBL26790	C33H36Cl2N4O2	591.577	3 / 1	6.1	No
3429	CHEMBL288371	C28H28N2O2S	456.604	4 / 1	4.7	Yes
3447	CHEMBL337789	C25H29F6N3O3	533.515	11 / 1	3.5	No
3448	CHEMBL1084165	C29H30ClF6N3O3	618.017	11 / 2	6.2	No
3515	CHEMBL166827	C32H40Cl4N4O6S	750.554	8 / 1	3.7	No
3849	CEP-11981	C28H27N7O	477.572	5 / 2	3.9	Yes
3973	CHEMBL341681	C28H27F2N3O3	491.539	5 / 3	5.2	No
4672	CHEMBL1765500	C28H28F6N4O	550.549	10 / 0	5.9	No
463457	CHEMBL3596492	C28H27F3N2O	464.532	6 / 0	6.1	No
4838	CHEMBL2112211	C30H27F6N3O3	591.554	9 / 2	6.2	No
5216	CHEMBL296014	C32H47N3O5	553.744	5 / 4	5.6	No
5397	CHEMBL42800	C23H23F6N3O2	487.446	9 / 2	4.1	Yes
5405	CHEMBL137972	C29H41N3O2	463.666	4 / 1	4.8	Yes
5705	CHEMBL357303	C19H20Cl2N4O2	407.295	4 / 2	3.4	Yes
5755	paroxetine	C19H20FNO3	329.371	5 / 1	3.5	Yes
6022	CHEMBL336251	C25H30F6N2O	488.518	9 / 0	6.0	No
6026	CHEMBL313070	C24H26F6N2O	472.475	8 / 1	5.4	No
6045	CHEMBL75367	C32H38Cl2F6N4O4	727.57	13 / 1	6.0	No
6047	CHEMBL75436	C32H38Cl2F6N4O4	727.57	13 / 1	6.0	No
6179	CHEMBL317297	C30H34N2O2	454.614	4 / 1	5.6	No
6195	CHEMBL420876	C29H32N2	408.589	2 / 1	6.0	No
6196	CHEMBL316842	C29H32N2	408.589	2 / 1	6.0	No
6452	CHEMBL445357	C30H33Cl2N3O3S2	618.632	6 / 1	5.4	No
6649	CHEMBL54540	C30H31Cl4N3O4S	671.455	6 / 1	5.9	No
7266	CHEMBL2112245	C74H92FN15O17S2	1546.76	22 / 19	-0.3	No
7547	CHEMBL139256	C28H36F3N3O2	503.61	7 / 1	5.2	No
7953	CHEMBL106300	C34H39Cl2N5O3	636.618	5 / 2	4.6	No
7954	CHEMBL107306	C34H39Cl2N5O3	636.618	5 / 2	4.6	No
7957	CHEMBL423597	C19H24N2O	296.414	3 / 2	2.7	Yes
8035	CHEMBL2370513	C42H54N8O9	814.941	9 / 8	2.9	No
8221	CHEMBL1951633	C24H24F7N3O2	519.464	9 / 1	4.2	No
8304	CHEMBL209531	C22H23F6NO	431.422	8 / 1	5.5	No
8427	CHEMBL3144347	C42H46N6O7	746.865	7 / 3	4.2	No
8432	CHEMBL45085	C42H46N6O7	746.865	7 / 3	4.2	No
8982	CHEMBL20826	C29H30ClN3O2	488.028	3 / 1	4.6	Yes
9058	CHEMBL207698	C23H23F6NO	443.433	8 / 1	5.8	No
9059	CHEMBL382988	C23H23F6NO	443.433	8 / 1	5.8	No
9142	CHEMBL208900	C27H25N3O2	423.516	3 / 1	3.9	Yes
9226	CHEMBL317209	C25H23F6N3O3S	559.527	11 / 0	3.5	No
9301	CHEMBL20736	C35H34ClN3O2	564.126	3 / 1	6.2	No
9359	CHEMBL120589	C22H25NO	319.448	2 / 1	4.6	Yes
9360	CHEMBL68670	C22H25NO	319.448	2 / 1	4.6	Yes
9429	CHEMBL301618	C33H33F7N2O	606.629	9 / 1	8.4	No
9451	CHEMBL319474	C33H38Cl2N4O4	625.591	6 / 1	5.1	No
9776	CHEMBL380510	C30H32F6N4O	578.603	10 / 0	7.1	No
9820	CHEMBL1270464	C26H26F6N4O	524.511	11 / 2	5.5	No
9869	AC-42	C20H31NO	301.474	2 / 0	5.2	No
9956	CHEMBL387670	C61H73F6N9O10	1206.3	17 / 8	8.1	No
10040	CHEMBL144793	C25H32N4O	404.558	4 / 2	3.7	Yes
557571	SCHEMBL17254991	C34H35F7N2O4	668.653	12 / 2	7.2	No
10200	CHEMBL1090438	C29H28F7NO3	571.536	10 / 0	5.5	No
10246	CHEMBL168144	C34H40Cl4N6O3	722.533	6 / 0	6.4	No
10603	CHEMBL56372	C23H24BrNO	410.355	2 / 1	5.2	No
521746	CHEMBL3735396	C41H57N7O11S	856.005	12 / 8	1.5	No
521749	CHEMBL3735210	C41H57N7O11S	856.005	12 / 8	1.5	No
11050	CHEMBL2333642	C19H19ClF4N2O	402.818	7 / 1	4.3	Yes
11074	CHEMBL287369	C33H40Cl4N8O3	738.536	8 / 0	6.4	No
11141	CHEMBL139057	C29H39N3O4	493.648	6 / 0	4.1	Yes
12343	CHEMBL203113	C33H33F6N5O3	661.649	10 / 3	5.4	No
12445	CHEMBL41068	C35H42Cl2F6N4O5	783.634	14 / 0	7.0	No
12539	CHEMBL105847	C36H37ClN4O2S	625.228	3 / 2	6.8	No
521828	CHEMBL3736313	C40H56N8O11S	856.993	13 / 9	-2.0	No
12653	CHEMBL1917867	C26H30F3N7O3	545.567	10 / 1	2.5	No
12963	CHEMBL1817830	C26H26ClF2NO2	457.946	5 / 1	N/A	N/A
13477	CHEMBL151356	C33H42Cl2N4O2	597.625	4 / 1	5.0	No
13533	CHEMBL424301	C20H24N6O	364.453	6 / 2	2.8	Yes
13712	CHEMBL342341	C32H38Cl2F6N4O3	711.571	12 / 1	6.9	No
13771	Aprepitant	C23H21F7N4O3	534.435	12 / 2	4.2	No
13773	ent-Aprepitant	C23H21F7N4O3	534.435	12 / 2	4.2	No
14024	CHEMBL1766208	C61H74F6N10O9S	1237.37	17 / 10	7.3	No
14089	CHEMBL611925	C57H64F6N10O9S2	1211.31	18 / 10	6.0	No
14093	CHEMBL611924	C57H64F6N10O9S2	1211.31	18 / 10	6.0	No
14107	CHEMBL2114398	C27H26ClF6N3O3	589.963	9 / 2	5.6	No
14110	CHEMBL2112070	C27H26ClF6N3O3	589.963	9 / 2	5.6	No
14111	CHEMBL35857	C27H26ClF6N3O3	589.963	9 / 2	5.6	No
14113	CHEMBL104954	C27H26ClF6N3O3	589.963	9 / 2	5.6	No
14115	CHEMBL2115343	C27H26ClF6N3O3	589.963	9 / 2	5.6	No
14137	CHEMBL1090285	C31H23F7N2O2	588.526	10 / 0	6.5	No

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