Online Services

●I-TASSER ●D-I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●D-QUARK ●DRfold ●DRfold2 ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●ATGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●DMFold ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred ●TCRfinder

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●TM-search ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●DeepMSA2 ●rMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●HPmod ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

You can:

Check the GPCR table for details.
Go to the ligand list to see ligands that interacts with this GPCR.
Go to the individual ligand page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

GPCR

Name	Somatostatin receptor type 4
Species	Homo sapiens (Human)
Gene	SSTR4
Synonym	SS4R SS4-R SS-4-R SRIF2B SST4 receptor
Disease	N/A
Length	388
Amino acid sequence	MSAPSTLPPGGEEGLGTAWPSAANASSAPAEAEEAVAGPGDARAAGMVAIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASSAALRHWPFGSVLCRAVLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAIFADTRPARGGQAVACNLQWPHPAWSAVFVVYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVVVFVLCWMPFYVVQLLNLFVTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRFFQRVLCLRCCLLEGAGGAEEEPLDYYATALKSKGGAGCMCPPLPCQQEALQPEPGRKRIPLTRTTTF
UniProt	P31391
Protein Data Bank	N/A
GPCR-HGmod model	P31391
3D structure model	This predicted structure model is from GPCR-EXP P31391.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1853
IUPHAR	358
DrugBank	BE0009273

Known ligands

You can:

Click GLASS IDs to check the association information.
Click ligand names to check details of the ligands.
Download a TSV version of all interaction information.
Download a SDF structure collection of all known ligands.

GLASS ID	Molecule	Formula	Molecular weight	H-bond acceptor / donor	XlogP	Lipinski's druglikeness
642	CHEMBL2112935	C23H21N5	367.456	3 / 2	3.9	Yes
804	CHEMBL406000	C60H74N12O10	1123.33	11 / 12	3.1	No
1286	BIM 23197	C57H81N13O13S3	1252.53	19 / 14	0.0	No
3836	CHEMBL1079007	C22H27N3O2S	397.537	6 / 2	6.0	No
4677	CHEMBL29102	C33H43NO6	549.708	7 / 1	4.2	No
441926	CHEMBL3350903	C55H68N12O12S2	1153.34	16 / 15	-0.2	No
441931	CHEMBL3350904	C55H68N12O12S2	1153.34	16 / 15	-0.2	No
6421	CHEMBL412183	C55H68N12O12S2	1153.34	16 / 15	-0.2	No
6426	CHEMBL438546	C55H68N12O12S2	1153.34	16 / 15	-0.2	No
7570	CHEMBL451932	C55H74ClN13O10S2	1176.85	14 / 14	3.1	No
9212	CHEMBL1161333	C54H65N11O12S2	1124.3	15 / 13	0.3	No
9218	CHEMBL2093027	C54H65N11O12S2	1124.3	15 / 13	0.3	No
9459	CHEMBL216992	C60H78N12O11S2	1207.48	16 / 14	0.6	No
10479	CHEMBL2369756	C58H69ClN12O9S2	1177.83	14 / 11	3.8	No
10486	CHEMBL1794041	C58H69ClN12O9S2	1177.83	14 / 11	3.8	No
10539	CHEMBL503379	C41H48F3N7O7S	839.932	12 / 5	N/A	No
10930	CHEMBL92545	C31H34N4O2S	526.699	4 / 2	4.4	No
10935	CHEMBL93618	C31H34N4O2S	526.699	4 / 2	4.4	No
11590	CHEMBL410047	C62H79N13O14S2	1294.51	18 / 16	-1.0	No
11901	CHEMBL391951	C23H29N3O3	395.503	6 / 1	5.0	Yes
12001	CHEMBL502077	C78H101ClN18O18S2	1678.34	25 / 18	-5.4	No
12327	CHEMBL265839	C76H104N16O18S2	1593.88	23 / 21	-0.9	No
13370	CHEMBL2011461	C46H60N8O7	837.035	8 / 6	4.3	No
13545	CHEMBL1077722	C21H26N4O3	382.464	7 / 1	3.4	Yes
442227	CHEMBL3350882	C58H72N12O13S2	1209.41	16 / 15	0.2	No
14940	CHEMBL263292	C58H72N12O13S2	1209.41	16 / 15	0.2	No
14960	CHEMBL504838	C35H38F3N5O5	665.714	9 / 5	N/A	No
14968	CHEMBL462020	C35H38F3N5O5	665.714	9 / 5	N/A	No
15212	CHEMBL429164	C84H111N17O18S2	1711.03	23 / 21	0.0	No
15950	CHEMBL254500	C26H30BrN5O2	524.463	4 / 1	3.1	No
15962	CHEMBL252231	C26H30BrN5O2	524.463	4 / 1	3.1	No
521926	AM-0902	C17H15ClN6O2	370.797	6 / 0	2.3	Yes
16293	BDBM84629	C71H81N11O9	1232.5	11 / 12	8.1	No
17119	CHEMBL406260	C58H70N12O8S2	1127.39	13 / 11	4.0	No
442333	CHEMBL3349676	C58H70N12O8S2	1127.39	13 / 11	4.0	No
17584	CHEMBL447177	C58H72ClN15O13S2	1286.88	17 / 17	-1.7	No
18093	CHEMBL413888	C81H106N16O17S2	1639.95	22 / 20	0.7	No
442381	CHEMBL3349610	C52H71N11O10S2	1074.33	14 / 13	1.9	No
18545	CHEMBL2370299	C52H71N11O10S2	1074.33	14 / 13	1.9	No
18952	CHEMBL3122128	C81H111N17O23S2	1754.99	30 / 19	-9.1	No
19915	CHEMBL1223226	C51H68N10O10	981.165	12 / 13	1.7	No
20635	CHEMBL414544	C57H69N9O11S2	1120.35	15 / 12	2.2	No
20641	CHEMBL2371100	C57H69N9O11S2	1120.35	15 / 12	2.2	No
20647	CHEMBL2371108	C57H69N9O11S2	1120.35	15 / 12	2.2	No
442484	CHEMBL3350357	C57H69N9O11S2	1120.35	15 / 12	2.2	No
20649	CHEMBL414272	C57H69N9O11S2	1120.35	15 / 12	2.2	No
20656	CHEMBL428281	C57H69N9O11S2	1120.35	15 / 12	2.2	No
20659	CHEMBL2111200	C57H69N9O11S2	1120.35	15 / 12	2.2	No
20664	CHEMBL2111257	C57H69N9O11S2	1120.35	15 / 12	2.2	No
20668	CHEMBL264046	C57H69N9O11S2	1120.35	15 / 12	2.2	No
20673	CHEMBL415582	C57H69N9O11S2	1120.35	15 / 12	2.2	No
24683	CHEMBL387005	C73H99IN16O15S2	1631.72	20 / 18	1.9	No
25078	CHEMBL384836	C50H67N11O11S2	1062.27	15 / 13	0.4	No
25590	CHEMBL440074	C81H105IN16O17S2	1765.85	22 / 20	1.4	No
26165	CHEMBL176730	C30H31N5	461.613	2 / 3	6.2	No
26263	CHEMBL1078449	C23H30N4O3	410.518	7 / 2	4.2	Yes
26748	CHEMBL434159	C27H28N6OS	484.622	6 / 2	3.7	Yes
442733	CHEMBL3349599	C56H62N8O8	975.16	9 / 8	5.5	No
27600	CHEMBL409754	C58H70N12O9S2	1143.39	14 / 12	3.6	No
442741	CHEMBL3349669	C58H70N12O9S2	1143.39	14 / 12	3.6	No
28077	sst4-selective analogue 17	C53H62N11O12S2-	1109.26	15 / 13	1.2	No
28630	BDBM50136762	C55H67N12O11S2-	1136.33	15 / 11	3.7	No
28803	CHEMBL2369735	C56H68ClN13O9S2	1166.81	14 / 12	2.6	No
28810	CHEMBL1793861	C56H68ClN13O9S2	1166.81	14 / 12	2.6	No
29009	CHEMBL282129	C42H51N3O5	677.886	7 / 3	6.0	No
442856	CHEMBL3349508	C66H78ClN11O10	1220.87	12 / 13	6.6	No
30543	CHEMBL1793962	C66H78ClN11O10	1220.87	12 / 13	6.6	No
442859	CHEMBL3349506	C66H78ClN11O10	1220.87	12 / 13	6.6	No
30547	CHEMBL1793960	C66H78ClN11O10	1220.87	12 / 13	6.6	No
30919	CHEMBL3122125	C82H126N22O27S2	1916.16	35 / 26	-14.6	No
33009	CHEMBL1791305	C74H102N20O19S2	1639.87	26 / 22	-5.2	No
33866	CHEMBL437448	C54H66Br2N12O8S2	1235.13	13 / 11	4.1	No
36271	CHEMBL502219	C59H70ClN13O10S2	1220.86	14 / 14	3.2	No
36291	CHEMBL442605	C28H35N5O3	489.62	4 / 4	2.3	Yes
37390	CHEMBL1794043	C60H71N13O9S2	1182.43	14 / 12	3.3	No
37392	CHEMBL2369758	C60H71N13O9S2	1182.43	14 / 12	3.3	No
37569	CHEMBL408471	C56H67N11O9S2	1102.34	12 / 11	3.9	No
37653	CHEMBL414446	C57H68IN9O10S2	1230.25	14 / 11	3.2	No
37661	CHEMBL407649	C57H68IN9O10S2	1230.25	14 / 11	3.2	No
38573	CHEMBL538948	C61H72IN11O10S2	1310.34	14 / 13	4.5	No
38578	CHEMBL538948	C61H72IN11O10S2	1308.34	14 / 13	4.5	No
39295	L-362855	C57H70N10O8	1023.25	9 / 11	5.7	No
522727	CHEMBL3780496	C24H24ClNO2	393.911	3 / 1	5.3	No
40403	CHEMBL559022	C74H96IN15O15S2	1626.7	20 / 19	3.5	No
40410	CHEMBL559022	C74H96IN15O15S2	1624.7	20 / 19	3.5	No
40443	CHEMBL267054	C51H70N10O10	983.181	12 / 13	1.7	No
40830	CHEMBL291474	C41H49N3O6	679.858	8 / 2	5.2	No
40896	CHEMBL3218121	C36H50N6O5	646.833	6 / 3	0.8	No
41330	CHEMBL436962	C61H78N12O14S2	1267.48	18 / 16	0.1	No
41384	CHEMBL439077	C63H76N12O12S2	1257.49	17 / 15	1.4	No
41391	CHEMBL437085	C63H76N12O12S2	1257.49	17 / 15	1.4	No
443320	CHEMBL3350894	C63H76N12O12S2	1257.49	17 / 15	1.4	No
443327	CHEMBL3350893	C63H76N12O12S2	1257.49	17 / 15	1.4	No
41989	CHEMBL508585	C70H92N16O20S2	1541.72	27 / 17	-6.0	No
43096	CHEMBL2112223	C30H37N5O2	499.659	3 / 4	3.9	Yes
43268	CHEMBL262551	C83H111N15O16S2	1639.01	22 / 18	2.4	No
43623	CHEMBL466609	C34H39N5O3	565.718	4 / 4	3.8	No
43628	CHEMBL476240	C34H39N5O3	565.718	4 / 4	3.8	No
44259	CHEMBL444639	C77H99N13O15S2	1510.83	20 / 16	2.9	No
45125	CHEMBL414717	C74H97N15O15S2	1500.8	20 / 19	2.8	No

zhanglab

zhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417