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Name | Adenosine receptor A2a |
---|---|
Species | Cavia porcellus (Guinea pig) |
Gene | ADORA2A |
Synonym | N/A |
Disease | N/A for non-human GPCRs |
Length | 409 |
Amino acid sequence | MSSSVYITVELVIAVLAILGNVLVCWAVWINSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFFACFVLVLTQSSIFSLLTITIDRYIAIRIPLRYNGLVTCTRAKGIIAICWVLSFAIGLTPMLGWNNCSQPKGDKNHSESCDEGQVTCLFEDVVPMNYMVYYNFFAFVLVPLLLMLGIYLRIFLAARRQLKQMESQPLPGERTRSTLQKEVHPAKSLAIIVGLFALCCLPLNIINCFTFFCPECDHAPPWLMYLTIILSHGNSVVNPLIYAYRIREFRQTFRKIIRSHILRRRELFKAGGTSARASAAHSPEGEQVSLRLNGHPPGVWANGSALRPEQRPNGYVLGLVSGRSAQRSHGDASLSDVELLSHEHKGTCPESPSLEDPPAHGGAGVS |
UniProt | P46616 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL2605 |
IUPHAR | N/A |
DrugBank | N/A |
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GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
---|---|---|---|---|---|---|
11024 | 3-Isobutyl-1-methylxanthine | C10H14N4O2 | 222.248 | 3 / 1 | 1.5 | Yes |
557637 | AC1OA4F2 | C13H12N4O3 | 272.264 | 4 / 2 | 2.1 | Yes |
16604 | CHEMBL446679 | C12H18N4O2 | 250.302 | 3 / 1 | 2.2 | Yes |
19530 | CHEMBL11146 | C14H12N4O4 | 300.274 | 5 / 2 | 2.0 | Yes |
24849 | 2-Chloroadenosine | C10H12ClN5O4 | 301.687 | 8 / 4 | -0.1 | Yes |
32278 | Allyltheobromine | C10H12N4O2 | 220.232 | 3 / 0 | 0.6 | Yes |
44742 | 1,3-Dipropyl-8-phenylxanthine | C17H20N4O2 | 312.373 | 3 / 1 | 4.0 | Yes |
48178 | CHEMBL25373 | C11H14N4O4 | 266.257 | 5 / 0 | -0.6 | Yes |
60476 | CHEMBL417654 | C10H14N4O2 | 222.248 | 3 / 0 | 0.8 | Yes |
62252 | Theophylline, 7-(2-propynyl)- | C10H10N4O2 | 218.216 | 3 / 0 | -0.2 | Yes |
64588 | CHEMBL423239 | C18H20N4O4 | 356.382 | 5 / 2 | 3.8 | Yes |
97353 | 1,3-Diethylxanthine | C9H12N4O2 | 208.221 | 3 / 1 | 0.9 | Yes |
98406 | 1,7-Dimethyl-3-isobutylxanthine | C11H16N4O2 | 236.275 | 3 / 0 | 1.3 | Yes |
560394 | CHEMBL27155 | C17H20N4O3 | 328.372 | 4 / 2 | 4.0 | Yes |
100691 | BRN 1229021 | C17H20N4O2 | 312.373 | 3 / 0 | 2.5 | Yes |
113030 | 1H-Purine-2,6-dione, 3,7-dihydro-1-methyl-3,7-dipropyl- | C12H18N4O2 | 250.302 | 3 / 0 | 1.3 | Yes |
114050 | 7-propyltheophylline | C10H14N4O2 | 222.248 | 3 / 0 | 0.4 | Yes |
122487 | 1-Isoamyl-3-isobutylxanthine | C14H22N4O2 | 278.356 | 3 / 1 | 3.1 | Yes |
127914 | 1-Butylxanthine | C9H12N4O2 | 208.221 | 3 / 2 | 1.0 | Yes |
138134 | 14114-46-6 | C10H10N4O2 | 218.216 | 3 / 0 | 0.0 | Yes |
138981 | 1,3-Diisobutylxanthine | C13H20N4O2 | 264.329 | 3 / 1 | 2.8 | Yes |
143128 | 1,3-Dipropyl-8-p-sulfophenylxanthine | C17H20N4O5S | 392.43 | 6 / 2 | 3.1 | Yes |
143184 | 1-Propylxanthine | C8H10N4O2 | 194.194 | 3 / 2 | 0.6 | Yes |
160668 | 1-methyl-3-ethylxanthine | C8H10N4O2 | 194.194 | 3 / 1 | 0.5 | Yes |
162473 | CHEMBL279688 | C20H26N4O5S | 434.511 | 6 / 2 | 4.3 | Yes |
171584 | CHEMBL127167 | C7H8N4O2 | 180.167 | 3 / 2 | 0.1 | Yes |
179441 | 1-Ethyl-3-methylxanthine | C8H10N4O2 | 194.194 | 3 / 1 | 0.3 | Yes |
181513 | 1-Methyl-3-butylxanthine | C10H14N4O2 | 222.248 | 3 / 1 | 1.3 | Yes |
191800 | CHEMBL131275 | C13H20N4O2 | 264.329 | 3 / 0 | 1.6 | Yes |
197956 | CHEMBL276830 | C13H13N5O2 | 271.28 | 4 / 2 | 1.5 | Yes |
198807 | 8-(p-Sulfophenyl)theophylline | C13H12N4O5S | 336.322 | 6 / 2 | 1.6 | Yes |
201659 | CHEMBL283412 | C11H16N4O2 | 236.275 | 3 / 0 | 0.7 | Yes |
201774 | Oprea1_100136 | C14H14N4O2 | 270.292 | 3 / 0 | 1.6 | Yes |
202248 | Xanthine, 1-methyl-3-propyl- | C9H12N4O2 | 208.221 | 3 / 1 | 1.0 | Yes |
207215 | 1,3-Dipropylxanthine | C11H16N4O2 | 236.275 | 3 / 1 | 1.9 | Yes |
213917 | CHEMBL589549 | C13H17N5 | 243.314 | 4 / 1 | 2.4 | Yes |
214636 | CHEMBL24444 | C13H16N4O2 | 260.297 | 3 / 0 | 1.1 | Yes |
215282 | 1-Methylxanthine | C6H6N4O2 | 166.14 | 3 / 2 | -0.3 | Yes |
217271 | 50908-62-8 | C13H16N6O4 | 320.309 | 8 / 4 | -0.5 | Yes |
223172 | 1,3-dibenzyl-3,7-dihydro-1h-purine-2,6-dione | C19H16N4O2 | 332.363 | 3 / 1 | 3.0 | Yes |
230448 | CHEMBL284860 | C14H20N4O2 | 276.34 | 3 / 0 | 2.1 | Yes |
232800 | CHEMBL286785 | C11H12N4O2 | 232.243 | 3 / 1 | 1.3 | Yes |
233892 | ETOFYLLINE | C9H12N4O3 | 224.22 | 4 / 1 | -1.2 | Yes |
247127 | FK-453 | C23H25N3O2 | 375.472 | 3 / 1 | 3.2 | Yes |
254647 | CHEMBL24445 | C13H18N4O2 | 262.313 | 3 / 0 | 1.6 | Yes |
258798 | CHEMBL11120 | C13H13N5O2 | 271.28 | 4 / 2 | 1.8 | Yes |
260985 | Rolofylline | C20H28N4O2 | 356.47 | 3 / 1 | 4.9 | Yes |
261117 | 8-Phenyltheophylline | C13H12N4O2 | 256.265 | 3 / 1 | 2.2 | Yes |
263321 | 1,3,7-Tripropylxanthine | C14H22N4O2 | 278.356 | 3 / 0 | 2.2 | Yes |
274834 | 7-(2-Chloroethyl)theophylline | C9H11ClN4O2 | 242.663 | 3 / 0 | 0.1 | Yes |
285023 | CHEMBL273953 | C14H12N4O4 | 300.274 | 5 / 2 | 1.7 | Yes |
287528 | 1,3-Dipropyl-7-methylxanthine | C12H18N4O2 | 250.302 | 3 / 0 | 1.7 | Yes |
297104 | (S)-PIA | C19H23N5O4 | 385.424 | 8 / 4 | 2.0 | Yes |
297118 | (R)-PIA | C19H23N5O4 | 385.424 | 8 / 4 | 2.0 | Yes |
308483 | caffeine | C8H10N4O2 | 194.194 | 3 / 0 | -0.1 | Yes |
312324 | PACPX | C17H20ClN5O2 | 361.83 | 4 / 2 | 4.0 | Yes |
315330 | ENPROFYLLINE | C8H10N4O2 | 194.194 | 3 / 2 | 0.3 | Yes |
318906 | ZINC36378427 | C6H4N4O2 | 164.124 | 2 / 0 | -0.6 | Yes |
325800 | CHEMBL25303 | C8H10N4O3 | 210.193 | 4 / 2 | -0.7 | Yes |
326771 | N6-Cyclohexyladenosine | C16H23N5O4 | 349.391 | 8 / 4 | 1.4 | Yes |
327026 | CHEMBL26176 | C13H20N4O2 | 264.329 | 3 / 0 | 1.7 | Yes |
345969 | CHEMBL28194 | C10H14N4O2 | 222.248 | 3 / 1 | 1.4 | Yes |
349603 | CHEMBL11054 | C13H12N4O3 | 272.264 | 4 / 2 | 1.8 | Yes |
360111 | BW A533U | C14H12N4O4 | 300.274 | 5 / 2 | 1.7 | Yes |
364348 | CHEMBL418193 | C18H22N4O2 | 326.4 | 3 / 0 | 2.9 | Yes |
385058 | 7-Benzyltheophylline | C14H14N4O2 | 270.292 | 3 / 0 | 1.1 | Yes |
385964 | 830-65-9 | C8H10N4O2 | 194.194 | 3 / 1 | 0.4 | Yes |
393440 | Theobromine, 1-propyl- | C10H14N4O2 | 222.248 | 3 / 0 | 0.8 | Yes |
396163 | CHEMBL20402 | C20H26N4O2 | 354.454 | 3 / 1 | 5.2 | No |
403448 | BRN 0240672 | C8H10N4O3 | 210.193 | 4 / 2 | -0.6 | Yes |
405555 | CHEMBL26406 | C12H14N4O2 | 246.27 | 3 / 0 | 1.2 | Yes |
570001 | AC1NU9TY | C13H12N4O3 | 272.264 | 4 / 2 | 1.8 | Yes |
410172 | CHEMBL11033 | C13H13N5O2 | 271.28 | 4 / 2 | 1.5 | Yes |
424553 | 3-isopropyl-1-methylxanthine | C9H12N4O2 | 208.221 | 3 / 1 | 0.8 | Yes |
427513 | theophylline | C7H8N4O2 | 180.167 | 3 / 1 | 0.0 | Yes |
427866 | 7-Allyltheophylline | C10H12N4O2 | 220.232 | 3 / 0 | 0.3 | Yes |
430022 | 102284-70-8 | C14H18N4O2 | 274.324 | 3 / 0 | 1.5 | Yes |
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