You can:
| Name | Smoothened homolog |
|---|---|
| Species | Mus musculus (Mouse) |
| Gene | Smo |
| Synonym | smoothened SMOH SMO FZD11 frizzled family member 11 [ Show all ] |
| Disease | N/A for non-human GPCRs |
| Length | 793 |
| Amino acid sequence | MAAGRPVRGPELAPRRLLQLLLLVLLGGPGRGAALSGNVTGPGPHSASGSSRRDVPVTSPPPPLLSHCGRAAHCEPLRYNVCLGSALPYGATTTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDHFPEGCPNEVQNIKFNSSGQCEAPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGTMRFGEPTSSETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKKPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGHSDDEPKRIKKSKMIAKAFSKRRELLQNPGQELSFSMHTVSHDGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDVSVTPVATPVPPEEQANMWLVEAEISPELEKRLGRKKKRRKRKKEVCPLRPAPELHHSAPVPATSAVPRLPQLPRQKCLVAANAWGTGESCRQGAWTLVSNPFCPEPSPHQDPFLPGASAPRVWAQGRLQGLGSIHSRTNLMEAEILDADSDF |
| UniProt | P56726 |
| Protein Data Bank | N/A |
| GPCR-HGmod model | N/A |
| 3D structure model | No available structures or models |
| BioLiP | N/A |
| Therapeutic Target Database | N/A |
| ChEMBL | CHEMBL6080 |
| IUPHAR | 239 |
| DrugBank | N/A |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 547907 |  CHEMBL3959631 | C27H30ClN3OS | 480.067 | 4 / 1 | 6.7 | No |
| 535952 |  CHEMBL3955601 | C25H28N6 | 412.541 | 5 / 1 | 4.6 | Yes |
| 4198 |  CHEMBL2152367 | C17H21NO3 | 287.359 | 3 / 1 | 2.6 | Yes |
| 536086 |  CHEMBL3938334 | C30H41N9O | 543.72 | 9 / 1 | 2.7 | No |
| 6389 |  CHEMBL2152368 | C18H22N2O4 | 330.384 | 4 / 2 | 1.4 | Yes |
| 536185 |  CHEMBL3983372 | C25H28FN5O2 | 449.53 | 8 / 0 | 4.2 | Yes |
| 463974 |  CHEMBL3604610 | C21H15ClN4O2S | 422.887 | 5 / 2 | 4.2 | Yes |
| 10212 |  CHEMBL497218 | C26H22N6O2 | 450.502 | 8 / 1 | 3.6 | Yes |
| 10758 |  CHEMBL497238 | C26H24N6 | 420.52 | 6 / 0 | 4.5 | Yes |
| 10759 |  CHEMBL497639 | C26H24N6 | 420.52 | 6 / 0 | 4.5 | Yes |
| 13402 |  CHEMBL1209455 | C26H22F3N5O | 477.491 | 8 / 0 | 4.4 | Yes |
| 536369 |  CHEMBL3920191 | C25H28N6O2 | 444.539 | 8 / 0 | 3.5 | Yes |
| 548053 |  CHEMBL3951626 | C27H24N2O5 | 456.498 | 5 / 2 | 4.7 | Yes |
| 536424 |  CHEMBL3922084 | C23H29N7O | 419.533 | 8 / 1 | 1.6 | Yes |
| 536432 |  CHEMBL3971451 | C23H24N2O5 | 408.454 | 5 / 3 | 4.3 | Yes |
| 536461 |  CHEMBL3965479 | C27H32N8O2 | 500.607 | 8 / 1 | 2.1 | No |
| 21111 |  CHEMBL474892 | C28H24F3N3OS | 507.575 | 7 / 2 | 6.1 | No |
| 21114 |  CHEMBL474893 | C28H24F3N3OS | 507.575 | 7 / 2 | 6.1 | No |
| 548150 |  CHEMBL3978393 | C29H28ClF3N4O2 | 557.014 | 7 / 1 | 7.0 | No |
| 536579 |  propyl 4-{[(4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)carbonyl]amino}benzoate | C21H20N2O5 | 380.4 | 5 / 2 | 3.2 | Yes |
| 536588 |  CHEMBL3953149 | C25H30N6O2 | 446.555 | 8 / 1 | 2.7 | Yes |
| 536607 |  CHEMBL3921763 | C26H29F3N6O2 | 514.553 | 11 / 0 | 4.8 | No |
| 536608 |  SCHEMBL1833847 | C24H26N6 | 398.514 | 5 / 1 | 4.1 | Yes |
| 25254 |  CHEMBL474302 | C30H25F3N2O | 486.538 | 5 / 2 | 7.7 | No |
| 25388 |  CHEMBL2152371 | C22H29NO5 | 387.476 | 5 / 1 | 2.8 | Yes |
| 26514 |  CHEMBL2043431 | C22H23N3O3 | 377.444 | 4 / 2 | 3.5 | Yes |
| 536701 |  SCHEMBL1830420 | C24H25F3N6O2 | 486.499 | 11 / 1 | 4.1 | No |
| 548193 |  CHEMBL3960082 | C27H27ClN4O | 458.99 | 3 / 2 | 5.8 | No |
| 536732 |  1-ethyl-4-hydroxy-2-oxo-N-(4-oxo-2-pentyl-3(4H)-quinazolinyl)-1,2-dihydro-3-quinolinecarboxamide | C25H26N4O4 | 446.507 | 5 / 2 | 4.0 | Yes |
| 536736 |  CHEMBL3919524 | C27H27F4N5O | 513.541 | 10 / 0 | 5.1 | No |
| 29801 |  Vismodegib | C19H14Cl2N2O3S | 421.292 | 4 / 1 | 3.8 | Yes |
| 536770 |  CHEMBL3959511 | C30H36F3N5O2 | 555.646 | 10 / 0 | 6.7 | No |
| 536800 |  CHEMBL3903125 | C27H32F3N7O2 | 543.595 | 11 / 1 | 3.3 | No |
| 31906 |  CHEMBL2160067 | C28H25ClN6O | 496.999 | 6 / 2 | 5.6 | No |
| 548273 |  CHEMBL3906154 | C23H25ClN4O2 | 424.929 | 5 / 1 | 4.9 | Yes |
| 34521 |  CHEMBL473073 | C28H24ClN3O | 453.97 | 3 / 2 | 5.4 | No |
| 35110 |  CHEMBL495875 | C25H24N6O | 424.508 | 6 / 1 | 3.2 | Yes |
| 548324 |  CHEMBL3899175 | C24H26N2O5 | 422.481 | 5 / 2 | 4.5 | Yes |
| 38181 |  CHEMBL473896 | C31H27F3N2O | 500.565 | 5 / 2 | 7.1 | No |
| 537032 |  CHEMBL3959587 | C25H29F3N6O | 486.543 | 10 / 1 | 3.5 | Yes |
| 41524 |  CHEMBL2152362 | C32H33ClN2O4 | 545.076 | 4 / 2 | 5.4 | No |
| 41915 |  CHEMBL2160208 | C40H41N7O2 | 651.815 | 7 / 2 | 5.3 | No |
| 45185 |  CHEMBL473897 | C30H26F3N3O | 501.553 | 6 / 2 | 6.0 | No |
| 548457 |  CHEMBL3950627 | C23H23ClN2O5 | 442.896 | 5 / 2 | 4.7 | Yes |
| 537255 |  CHEMBL3979766 | C23H22N2O5 | 406.438 | 5 / 2 | 3.9 | Yes |
| 51921 |  CHEMBL474508 | C29H26F3N3OS | 521.602 | 7 / 2 | 6.5 | No |
| 537295 |  CHEMBL3975985 | C28H32F3N5O | 511.593 | 9 / 1 | 5.0 | No |
| 537352 |  SCHEMBL1829533 | C24H26N4O2 | 402.498 | 5 / 0 | 4.2 | Yes |
| 57701 |  CHEMBL1084738 | C27H23F3N4O | 476.503 | 7 / 0 | 5.5 | No |
| 537474 |  CHEMBL3916441 | C22H22F3N5 | 413.448 | 8 / 0 | 4.4 | Yes |
| 537589 |  CHEMBL3930063 | C21H21F3N6 | 414.436 | 9 / 0 | 3.4 | Yes |
| 471197 |  CHEMBL3604616 | C21H14ClFN4O2S | 440.877 | 6 / 2 | 4.3 | Yes |
| 75231 |  CHEMBL496014 | C24H23N5 | 381.483 | 5 / 0 | 4.4 | Yes |
| 75861 |  CHEMBL2152372 | C24H26ClNO3 | 411.926 | 3 / 0 | 4.8 | Yes |
| 76213 |  CHEMBL495608 | C26H21N7 | 431.503 | 7 / 0 | 3.8 | Yes |
| 537872 |  AC1MDGI7 | C19H20N4O5S | 416.452 | 7 / 2 | 4.3 | Yes |
| 537915 |  CHEMBL3986486 | C29H38N8O2 | 530.677 | 9 / 1 | 2.5 | No |
| 537938 |  SCHEMBL3205103 | C24H30N6O | 418.545 | 7 / 1 | 2.8 | Yes |
| 538028 |  SCHEMBL3200787 | C25H30N6 | 414.557 | 6 / 0 | 4.6 | Yes |
| 473085 |  CHEMBL3604612 | C21H14Cl2N4O2S | 457.329 | 5 / 2 | 4.9 | Yes |
| 548880 |  CHEMBL3890551 | C28H31ClN4O2S | 523.092 | 5 / 2 | 5.8 | No |
| 85114 |  CHEMBL473892 | C29H24F3N3O | 487.526 | 6 / 2 | 5.7 | No |
| 538125 |  CHEMBL3955346 | C25H26F3N5 | 453.513 | 8 / 0 | 5.2 | No |
| 538187 |  CHEMBL3965788 | C24H26N2O5 | 422.481 | 5 / 2 | 4.5 | Yes |
| 88511 |  CHEMBL523255 | C27H28N6O | 452.562 | 6 / 1 | 3.5 | Yes |
| 538219 |  SCHEMBL3213197 | C23H27N7O2 | 433.516 | 9 / 0 | 2.4 | Yes |
| 548966 |  CHEMBL3924243 | C28H33ClN2O5 | 513.031 | 6 / 1 | 5.1 | No |
| 538234 |  Purmorphamine | C31H32N6O2 | 520.637 | 7 / 1 | 6.5 | No |
| 90408 |  CHEMBL2152381 | C24H25Cl2N3O4 | 490.381 | 5 / 2 | 3.0 | Yes |
| 90879 |  CHEMBL516370 | C30H26F3N3O2 | 517.552 | 7 / 2 | 5.6 | No |
| 94456 |  CHEMBL2152370 | C22H27F3N2O4 | 440.463 | 7 / 2 | 3.1 | Yes |
| 95111 |  CHEMBL2043430 | C22H17N3O3 | 371.396 | 4 / 2 | 3.7 | Yes |
| 538358 |  CHEMBL3953985 | C23H21F6N5 | 481.446 | 11 / 0 | 5.3 | No |
| 538379 |  CHEMBL3950687 | C25H28F3N7O | 499.542 | 10 / 1 | 3.9 | Yes |
| 538394 |  CHEMBL3974265 | C30H30N2O5 | 498.579 | 5 / 2 | 6.2 | No |
| 549094 |  CHEMBL3890227 | C26H30N2O5 | 450.535 | 5 / 2 | 5.6 | No |
| 549096 |  CHEMBL3986975 | C26H31N3O4 | 449.551 | 4 / 3 | 5.0 | Yes |
| 538458 |  SCHEMBL1835540 | C26H30N4 | 398.554 | 4 / 0 | 4.6 | Yes |
| 538512 |  SCHEMBL1834663 | C24H31N7O | 433.56 | 8 / 1 | 1.9 | Yes |
| 538529 |  SCHEMBL3213258 | C24H30N6O2 | 434.544 | 8 / 2 | 1.7 | Yes |
| 538535 |  SCHEMBL1830461 | C24H27N5O | 401.514 | 4 / 1 | 3.6 | Yes |
| 538555 |  CHEMBL3983242 | C26H27F3N6O2 | 512.537 | 11 / 0 | 4.4 | No |
| 106861 |  CHEMBL2152358 | C26H27ClN2O4 | 466.962 | 4 / 2 | 3.5 | Yes |
| 538638 |  CHEMBL3899187 | C24H24F3N5 | 439.486 | 8 / 0 | 4.8 | Yes |
| 108305 |  CHEMBL497819 | C26H23N5 | 405.505 | 5 / 0 | 4.8 | Yes |
| 538650 |  CHEMBL3941789 | C24H26N2O5 | 422.481 | 5 / 2 | 4.5 | Yes |
| 476415 |  CHEMBL3604615 | C21H14ClFN4O2S | 440.877 | 6 / 2 | 4.3 | Yes |
| 538679 |  SCHEMBL1832485 | C25H29N5O | 415.541 | 4 / 1 | 3.6 | Yes |
| 115373 |  CHEMBL522241 | C26H21F3N6 | 474.491 | 9 / 0 | 5.0 | Yes |
| 549302 |  CHEMBL3909304 | C28H29F3N2O2 | 482.547 | 6 / 1 | 7.2 | No |
| 538980 |  CHEMBL3891481 | C26H33N7O3 | 491.596 | 9 / 3 | 1.5 | Yes |
| 538983 |  CHEMBL3974732 | C25H29F3N6O2 | 502.542 | 11 / 1 | 3.5 | No |
| 539015 |  CHEMBL3903318 | C26H30N2O5 | 450.535 | 5 / 2 | 5.5 | No |
| 122609 |  CHEMBL2152369 | C23H31N3O4 | 413.518 | 5 / 1 | 1.3 | Yes |
| 124842 |  CHEMBL497003 | C23H22N6 | 382.471 | 6 / 0 | 3.3 | Yes |
| 127275 |  CHEMBL514764 | C29H25F3N2O2 | 490.526 | 6 / 2 | 6.2 | No |
| 128148 |  CHEMBL496604 | C25H21ClN6 | 440.935 | 6 / 0 | 4.7 | Yes |
| 478723 |  CHEMBL3604623 | C22H16Cl2N4OS | 455.357 | 5 / 2 | 6.2 | No |
| 128306 |  CHEMBL2152374 | C24H26ClN3O4 | 455.939 | 4 / 2 | 3.1 | Yes |
| 539298 |  SCHEMBL1836304 | C24H30N6O2 | 434.544 | 8 / 1 | 2.9 | Yes |
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