Online Services

●I-TASSER ●D-I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●D-QUARK ●DRfold ●DRfold2 ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●ATGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●DMFold ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred ●TCRfinder

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●TM-search ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●DeepMSA2 ●rMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●HPmod ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

You can:

Check the GPCR table for details.
Go to the ligand list to see ligands that interacts with this GPCR.
Go to the individual ligand page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

GPCR

Name	Adenosine receptor A2a
Species	Mus musculus (Mouse)
Gene	Adora2a
Synonym	A2-AR A2A receptor adenosine receptor A2a RDC8
Disease	N/A for non-human GPCRs
Length	410
Amino acid sequence	MGSSVYIMVELAIAVLAILGNVLVCWAVWINSNLQNVTNFFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGMRAKGIIAICWVLSFAIGLTPMLGWNNCSQKDENSTKTCGEGRVTCLFEDVVPMNYMVYYNFFAFVLLPLLLMLAIYLRIFLAARRQLKQMESQPLPGERTRSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCSTCQHAPPWLMYLAIILSHSNSVVNPFIYAYRIREFRQTFRKIIRTHVLRRQEPFRAGGSSAWALAAHSTEGEQVSLRLNGHPLGVWANGSAPHSGRRPNGYTLGPGGGGSTQGSPGDVELLTQEHQEGQEHPGLGDHLAQGRVGTASWSSEFAPS
UniProt	Q60613
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2115
IUPHAR	19
DrugBank	N/A

Known ligands

You can:

Click GLASS IDs to check the association information.
Click ligand names to check details of the ligands.
Download a TSV version of all interaction information.
Download a SDF structure collection of all known ligands.

GLASS ID	Molecule	Formula	Molecular weight	H-bond acceptor / donor	XlogP	Lipinski's druglikeness
1203	CHEMBL178846	C22H25ClN6O5	488.929	9 / 4	1.3	Yes
4755	CHEMBL27376	C20H20ClIN6O3	554.773	7 / 4	2.0	No
9821	CHEMBL2089350	C33H28ClN5O2	562.07	6 / 3	5.6	No
442798	CHEMBL2064639	C22H21FN6O3	436.447	8 / 4	1.1	Yes
443797	CHEMBL2402025	C29H28N6O6S	588.639	10 / 5	1.7	No
53565	CHEMBL2064655	C28H24Cl2N6O3	563.439	7 / 4	3.7	No
553499	MRS5151	C26H27ClN6O5	538.989	9 / 5	1.6	No
60677	CHEMBL2064659	C29H25ClN6O5	573.006	9 / 5	2.6	No
82292	CHEMBL255907	C22H25IN6O5	580.383	9 / 4	1.0	No
90124	CHEMBL2089346	C27H25N5O2	451.53	6 / 3	3.5	Yes
92062	CHEMBL175543	C20H20Cl2N6O3	463.319	7 / 4	2.0	Yes
101161	CHEMBL283057	C14H17ClN6O3	352.779	7 / 4	-0.1	Yes
104060	CHEMBL368872	C27H27ClN6O3	519.002	7 / 4	3.3	No
446273	CHEMBL3407774	C20H20N8O3	420.433	9 / 4	-1.1	Yes
446402	CHEMBL3407783	C20H20N6O3S	424.479	8 / 4	0.7	Yes
121530	CHEMBL256520	C26H27ClN6O5	538.989	9 / 5	1.9	No
123576	CHEMBL2064656	C28H24Cl2N6O3	563.439	7 / 4	3.7	No
124372	IB-MECA	C18H19IN6O4	510.292	8 / 4	0.9	No
126968	CHEMBL425741	C20H20BrClN6O3	507.773	7 / 4	2.1	No
127341	CHEMBL2064640	C22H21ClN6O3	452.899	7 / 4	1.6	Yes
130400	CHEMBL402607	C14H17ClN6O4	368.778	8 / 4	-0.1	Yes
446941	CHEMBL2089345	C32H26ClN5O2	548.043	6 / 3	5.3	No
553963	ATL802	C24H22F3N7O3	513.481	9 / 1	2.9	No
137493	CHEMBL178644	C23H23ClN6O4	482.925	8 / 5	0.9	Yes
138943	2-Cl-IB-Meca	C18H18ClIN6O4	544.734	8 / 4	1.9	No
447758	CHEMBL3407777	C20H22N8O3	422.449	8 / 4	-0.7	Yes
172067	CHEMBL256312	C28H33ClN8O4	581.074	9 / 6	0.7	No
182177	CHEMBL2064653	C28H25ClN6O3	528.997	7 / 4	3.1	No
448877	CHEMBL3407785	C20H19BrN6O3S	503.375	8 / 4	1.7	No
188775	CHEMBL2089340	C21H20ClN5O2	409.874	6 / 3	2.6	Yes
196791	CHEMBL402574	C22H21ClN6O3	452.899	7 / 4	1.3	Yes
199446	MRS 5698	C28H23ClF2N6O3	564.978	9 / 4	3.3	No
221196	CHEMBL2064654	C28H24ClFN6O3	546.987	8 / 4	3.2	No
238311	CHEMBL2402023	C27H25N5O5S	531.587	9 / 4	2.3	No
253417	CHEMBL2089335	C20H19N5O2	361.405	6 / 3	1.6	Yes
274623	CHEMBL175444	C20H20ClIN6O3	554.773	7 / 4	1.7	No
279240	CHEMBL2064658	C28H26ClN7O3	544.012	8 / 5	2.4	No
293841	CHEMBL257405	C25H29ClN6O3Si	525.081	7 / 4	N/A	No
453334	CHEMBL3407778	C20H20N6O4	408.418	8 / 4	0.1	Yes
453822	CHEMBL3407784	C20H19ClN6O3S	458.921	8 / 4	1.7	Yes
314974	CHEMBL436649	C27H29ClN6O5	553.016	9 / 4	1.9	No
327781	CHEMBL175814	C21H23ClN6O3S	474.964	8 / 4	1.9	Yes
350084	CHEMBL411861	C22H23ClN6O3	454.915	7 / 4	1.8	Yes
351328	CHEMBL2401954	C28H25ClN6O6S	609.054	10 / 5	1.8	No
359731	CHEMBL2064661	C38H29ClN6O3	653.139	7 / 4	6.2	No
365913	CHEMBL257833	C26H27ClN6O5	538.989	9 / 5	1.6	No
375341	CHEMBL257573	C30H35ClN8O5	623.111	9 / 6	1.0	No
392279	CHEMBL2402024	C29H28N6O3	508.582	7 / 4	2.9	No
392921	CHEMBL258421	C25H27ClN6O3	494.98	7 / 4	2.8	Yes
395904	CHEMBL2064660	C34H29ClN6O3	605.095	7 / 4	4.7	No
417309	CHEMBL257785	C28H33ClN8O4	581.074	9 / 6	0.4	No
430315	CHEMBL2401955	C28H25ClN6O6S	609.054	10 / 5	1.8	No
431159	CHEMBL2089339	C21H21N5O2	375.432	6 / 3	1.9	Yes

zhanglab

zhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417