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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	Meclinertant
Molecular formula	C32H31ClN4O5
IUPAC name	2-[[1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazole-3-carbonyl]amino]adamantane-2-carboxylic acid
Molecular weight	587.073
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	5.8
Synonyms	146362-70-1 2-[[[1-(7-Chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl]amino]-tricyclo[3.3.1.13,7]decane-2-carboxylic acid BCP0726000168 DTXSID40163360 MLS-0437456.0001 RL01839 Tricyclo(3.3.1.13,7)decane-2-carboxylic acid, 2-(((1-(7-chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl)carbonyl)amino)- 2-(((1-(7-Chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl)carbonyl)amino)tricyclo(3.3.1.1(sup 3,7))decane-2-carboxylic acid 5JBP4SI96H C32H31ClN4O5 J-507678 NCGC00242503-01 SMR004701645 ZINC1482927 2-[[1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazole-3-carbonyl]amino]adamantane-2-carboxylic acid B7484 CHEMBL506981 QC-4586 SR-48692 2-{[1-(7-Chloro-quinolin-4-yl)-5-(2,6-dimethoxy-phenyl)-1H-pyrazole-3-carbonyl]-amino}-adamantane-2-carboxylic acid BDBM50248034 FT-0733910 MLS006010645 S-265 UNII-5JBP4SI96H 2-((1-(7-Chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl)carbonylamino)tricyclo(3.3.1.1.(3.7))decan-2-carboxylic acid AC1L3OCW CHEBI:125516 L001448 PDSP1_000642 SR 48692 2-[[1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazole-3-carbonyl]amino]adamantane-2-carboxylic acid. BCP03645 D0G0TS Meclinertant [INN] Reminertant SR48692 2-(((1-(7-Chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl)carbonyl)amino)tricyclo(3.3.1.1(sup 3,7) )decane-2-carboxylic acid BRD-K25075681-001-01-2 GTPL1582 MolPort-023-276-909 SCHEMBL1650932 X5495 2-(1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxamido)adamantane-2-carboxylic acid AKOS024457771 LS-184738 PDSP2_000637 SR 48692, >=98% (HPLC) [ Show all ]
Inchi Key	DYLJVOXRWLXDIG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C32H31ClN4O5/c1-41-27-4-3-5-28(42-2)29(27)26-16-24(36-37(26)25-8-9-34-23-15-21(33)6-7-22(23)25)30(38)35-32(31(39)40)19-11-17-10-18(13-19)14-20(32)12-17/h3-9,15-20H,10-14H2,1-2H3,(H,35,38)(H,39,40)
PubChem CID	119192
ChEMBL	CHEMBL506981
IUPHAR	1582
BindingDB	50248034
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
72074	D(1A) dopamine receptor	P21728	DRD1	Homo sapiens (Human)	446
72067	D(1B) dopamine receptor	P21918	DRD5	Homo sapiens (Human)	477
72072	D(2) dopamine receptor	P14416	DRD2	Homo sapiens (Human)	443
72070	D(3) dopamine receptor	P35462	DRD3	Homo sapiens (Human)	400
72069	D(4) dopamine receptor	P21917	DRD4	Homo sapiens (Human)	467
72065	Neurotensin receptor type 1	P20789	Ntsr1	Rattus norvegicus (Rat)	424
72066	Neurotensin receptor type 1	P30989	NTSR1	Homo sapiens (Human)	418
72068	Neurotensin receptor type 2	Q63384	Ntsr2	Rattus norvegicus (Rat)	416
72071	Neurotensin receptor type 2	O95665	NTSR2	Homo sapiens (Human)	410
553628	Neurotensin receptor type 2	P70310	Ntsr2	Mus musculus (Mouse)	416

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